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The continuous integration of experimental data into coherent models of the brain is an increasing challenge of modern neuroscience. Such models provide a bridge between structure and activity, and identify the mechanisms giving rise to…

Neurons and Cognition · Quantitative Biology 2017-03-03 Jannis Schuecker , Maximilian Schmidt , Sacha J. van Albada , Markus Diesmann , Moritz Helias

Recent neuroimaging studies that focus on predicting brain disorders via modern machine learning approaches commonly include a single modality and rely on supervised over-parameterized models.However, a single modality provides only a…

We address prevailing challenges of the brain-powered research, departing from the observation that the literature hardly recover accurate spatial information and require subject-specific models. To address these challenges, we propose…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Weihao Xia , Raoul de Charette , Cengiz Öztireli , Jing-Hao Xue

Intracranial recordings have opened a unique opportunity to simultaneously measure activity across multiregional networks in the human brain. Recent works have focused on developing transformer-based neurofoundation models of such…

Machine Learning · Computer Science 2025-12-16 Lucine L. Oganesian , Saba Hashemi , Maryam M. Shanechi

Structural magnetic resonance imaging (sMRI) provides accurate estimates of the brain's structural organization and learning invariant brain representations from sMRI is an enduring issue in neuroscience. Previous deep representation…

Computer Vision and Pattern Recognition · Computer Science 2023-06-21 Ning Jiang , Gongshu Wang , Tianyi Yan

Pre-training has shown success in different areas of machine learning, such as Computer Vision, Natural Language Processing (NLP), and medical imaging. However, it has not been fully explored for clinical data analysis. An immense amount of…

Machine Learning · Computer Science 2023-07-18 Chantal Pellegrini , Nassir Navab , Anees Kazi

Understanding neural activity and information representation is crucial for advancing knowledge of brain function and cognition. Neural activity, measured through techniques like electrophysiology and neuroimaging, reflects various aspects…

Neurons and Cognition · Quantitative Biology 2024-07-22 Fengyu Yang , Chao Feng , Daniel Wang , Tianye Wang , Ziyao Zeng , Zhiyang Xu , Hyoungseob Park , Pengliang Ji , Hanbin Zhao , Yuanning Li , Alex Wong

Mental and cognitive representations are believed to reside on low-dimensional, non-linear manifolds embedded within high-dimensional brain activity. Uncovering these manifolds is key to understanding individual differences in brain…

Machine Learning · Computer Science 2025-05-02 Eloy Geenjaar , Vince Calhoun

Modern scientific fields face the challenge of integrating a wealth of data, analyses, and results. We recently showed that a neglect of this integration can lead to circular analyses and redundant explanations. Here, we help advance…

Neurons and Cognition · Quantitative Biology 2025-08-15 Mika Rubinov

Masked Image Modeling (MIM) achieves outstanding success in self-supervised representation learning. Unfortunately, MIM models typically have huge computational burden and slow learning process, which is an inevitable obstacle for their…

Computer Vision and Pattern Recognition · Computer Science 2023-03-10 Haoqing Wang , Yehui Tang , Yunhe Wang , Jianyuan Guo , Zhi-Hong Deng , Kai Han

We present a multi-scale spiking network model of all vision-related areas of macaque cortex that represents each area by a full-scale microcircuit with area-specific architecture. The layer- and population-resolved network connectivity…

Neurons and Cognition · Quantitative Biology 2018-10-23 Maximilian Schmidt , Rembrandt Bakker , Kelly Shen , Gleb Bezgin , Claus-Christian Hilgetag , Markus Diesmann , Sacha J. van Albada

Recording simultaneous activity of hundreds of neurons is now possible. Existing methods can model such population activity, but do not directly reveal the computations used by the brain. We present a fully unsupervised method that models…

Neurons and Cognition · Quantitative Biology 2020-03-24 Connor Brennan , Alex Proekt

Fitting network models to neural activity is an important tool in neuroscience. A popular approach is to model a brain area with a probabilistic recurrent spiking network whose parameters maximize the likelihood of the recorded activity.…

Machine Learning · Statistics 2021-11-16 Guillaume Bellec , Shuqi Wang , Alireza Modirshanechi , Johanni Brea , Wulfram Gerstner

Every day, the human brain processes an immense volume of visual information, relying on intricate neural mechanisms to perceive and interpret these stimuli. Recent breakthroughs in functional magnetic resonance imaging (fMRI) have enabled…

Computer Vision and Pattern Recognition · Computer Science 2023-05-22 Matteo Ferrante , Furkan Ozcelik , Tommaso Boccato , Rufin VanRullen , Nicola Toschi

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

Significant advancements has recently been achieved in the field of multi-modal large language models (MLLMs), demonstrating their remarkable capabilities in understanding and reasoning across diverse tasks. However, these models are often…

Computation and Language · Computer Science 2024-08-06 Zhaowei Li , Wei Wang , YiQing Cai , Xu Qi , Pengyu Wang , Dong Zhang , Hang Song , Botian Jiang , Zhida Huang , Tao Wang

Neurophysiological decoding, fundamental to advancing brain-computer interface (BCI) technologies, has significantly benefited from recent advances in deep learning. However, existing decoding approaches largely remain constrained to…

Signal Processing · Electrical Eng. & Systems 2025-08-07 Di Wu , Yifei Jia , Siyuan Li , Shiqi Zhao , Jie Yang , Mohamad Sawan

Recent advances in neural recording technology allow simultaneously recording action potentials from hundreds to thousands of neurons in awake, behaving animals. However, characterizing spike patterns in the resulting data, and linking…

Semi-supervised learning has recently been attracting attention as an alternative to fully supervised models that require large pools of labeled data. Moreover, optimizing a model for multiple tasks can provide better generalizability than…

Computer Vision and Pattern Recognition · Computer Science 2020-05-07 Abdullah-Al-Zubaer Imran , Chao Huang , Hui Tang , Wei Fan , Yuan Xiao , Dingjun Hao , Zhen Qian , Demetri Terzopoulos

Neural Processes (NPs) consider a task as a function realized from a stochastic process and flexibly adapt to unseen tasks through inference on functions. However, naive NPs can model data from only a single stochastic process and are…

Machine Learning · Computer Science 2022-03-28 Donggyun Kim , Seongwoong Cho , Wonkwang Lee , Seunghoon Hong