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The near-infinite chemical diversity of natural and artificial macromolecules arises from the vast range of possible component monomers, linkages, and polymers topologies. This enormous variety contributes to the ubiquity and…

Machine Learning · Computer Science 2021-08-25 Somesh Mohapatra , Joyce An , Rafael Gómez-Bombarelli

Designing new molecules with a set of predefined properties is a core problem in modern drug discovery and development. There is a growing need for de-novo design methods that would address this problem. We present MolecularRNN, the graph…

Machine Learning · Computer Science 2019-06-03 Mariya Popova , Mykhailo Shvets , Junier Oliva , Olexandr Isayev

Reticular materials, including metal-organic frameworks and covalent organic frameworks, combine relative ease of synthesis and an impressive range of applications in various fields, from gas storage to biomedicine. Diverse properties arise…

Materials Science · Physics 2024-03-11 Vadim Korolev , Artem Mitrofanov

Graphs serve as fundamental descriptors for systems composed of interacting elements, capturing a wide array of data types, from molecular interactions to social networks and knowledge graphs. In this paper, we present an exhaustive review…

Machine Learning · Computer Science 2024-11-13 Chenqing Hua

Molecular Representation Learning is essential to solving many drug discovery and computational chemistry problems. It is a challenging problem due to the complex structure of molecules and the vast chemical space. Graph representations of…

Machine Learning · Computer Science 2023-01-18 Atia Hamidizadeh , Tony Shen , Martin Ester

In chemical graph theory, topological indices are widely used as numerical descriptors for establishing quantitative structure-property relationships (QSPR) and quantitative structure-activity relationships (QSAR). These indices…

Chemical Physics · Physics 2025-11-05 U. Vijaya Chandra Kumar , H. M. Nagesh , Narahari N

Graph Transformers have recently attracted attention for molecular property prediction by combining the inductive biases of graph neural networks (GNNs) with the global receptive field of Transformers. However, many existing hybrid…

Machine Learning · Computer Science 2026-04-09 Yi Yang , Ovidiu Daescu

Graph Machine Learning (GML) is receiving growing interest within the pharmaceutical and biotechnology industries for its ability to model biomolecular structures, the functional relationships between them, and integrate multi-omic datasets…

Recent advances in (scanning) transmission electron microscopy have enabled routine generation of large volumes of high-veracity structural data on 2D and 3D materials, naturally offering the challenge of using these as starting inputs for…

Data Analysis, Statistics and Probability · Physics 2022-11-08 Ayana Ghosh , Maxim Ziatdinov , Ondrej Dyck , Bobby Sumpter , Sergei V. Kalinin

Recent advances in artificial intelligence have propelled the development of innovative computational materials modeling and design techniques. Generative deep learning models have been used for molecular representation, discovery, and…

Chemical Physics · Physics 2021-02-12 Navid Shervani-Tabar , Nicholas Zabaras

Hypergraphs require higher-dimensional representations, which makes it more difficult to compute and interpret their spectral properties. This survey article uses the framework of hypermatrices to give an in-depth overview of the spectral…

History and Overview · Mathematics 2025-07-21 Shashwath S Shetty , K Arathi Bhat

In this perspective article, we present a multidisciplinary approach for characterizing protein structure networks. We first place our approach in its historical context and describe the manner in which it synthesizes concepts from quantum…

Molecular Networks · Quantitative Biology 2019-12-30 Vasundhara Gadiyaram , Smitha Vishveshwara , Saraswathi Vishveshwara

Current experimental and theoretical studies on the effect of intermolecular interactions on molecular conduction appear to be in conflict with each other. In particular, some experimental results, e.g., the observation of 2-dimensional…

Mesoscale and Nanoscale Physics · Physics 2007-07-23 A. Landau , L. Kronik , A. Nitzan

A simple geometrical model is presented for the gravity-driven motion of a single particle on a rough inclined surface. Adopting a simple restitution law for the collisions between the particle and the surface, we arrive at a model in which…

Soft Condensed Matter · Physics 2009-10-31 Giovani L. Vasconcelos , J. J. P. Veerman

We show how arbitrary unit cells of periodic materials can be represented as graphs whose nodes represent atoms and whose weighted edges represent tunneling connections between atoms. Further, we present methods to calculate the band…

Other Condensed Matter · Physics 2024-12-20 R. Gerstner

String theory is the leading contemporary framework to explore the synthesis of quantum mechanics with gravity. String phenomenology aims to study string theory while maintaining contact with observational data. The fermionic $Z_2\times…

High Energy Physics - Theory · Physics 2020-03-18 Alon E Faraggi

By leveraging the fundamental doctrine of The Quantum Theory of Atoms in Molecules---the partitioning of the electron charge density ($\rho$) into regions bounded by surfaces of zero flux---we map the gradient field of $\rho$ onto a 2D…

Chemical Physics · Physics 2019-10-09 Timothy R Wilson , Mark E Eberhart

Knowing a biomolecule's structure is inherently linked to and a prerequisite for any detailed understanding of its function. Significant effort has gone into developing technologies for structural characterization. These technologies do not…

Data Structures and Algorithms · Computer Science 2017-06-22 Michael Wegner , Oskar Taubert , Alexander Schug , Henning Meyerhenke

We proposed the molecular hyper-message passing network (MolHMPN) that predicts the properties of a molecule with prior knowledge-guided subgraph. Modeling higher-order connectivities in molecules is necessary as changes in both the…

Computational Engineering, Finance, and Science · Computer Science 2022-01-05 Fangying Chen , Junyoung Park , Jinkyoo Park

Interactions between biomolecules, electrons and protons are essential to many fundamental processes sustaining life. It is therefore of interest to build mathematical models of these bioelectrical processes not only to enhance…

Molecular Networks · Quantitative Biology 2020-12-08 Peter J. Gawthrop , Michael Pan
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