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Deep learning techniques have shown their superior performance in dermatologist clinical inspection. Nevertheless, melanoma diagnosis is still a challenging task due to the difficulty of incorporating the useful dermatologist clinical…

Image and Video Processing · Electrical Eng. & Systems 2021-12-03 Xiaohong Wang , Xudong Jiang , Henghui Ding , Yuqian Zhao , Jun Liu

In multicenter biomedical research, integrating data from multiple decentralized sites provides more robust and generalizable findings due to its larger sample size and the ability to account for the between-site heterogeneity. However,…

Methodology · Statistics 2025-12-29 Xiaokang Liu , Yuchen Yang , Yifei Sun , Jiang Bian , Yanyuan Ma , Raymond J. Carroll , Yong Chen

The proliferation of fake news across diverse domains highlights critical limitations in current detection systems, which often exhibit narrow domain specificity and poor generalization. Existing cross-domain approaches face two key…

Artificial Intelligence · Computer Science 2026-04-07 Esma Aïmeur , Gilles Brassard , Dorsaf Sallami

Deep learning based medical image diagnosis has shown great potential in clinical medicine. However, it often suffers two major difficulties in practice: 1) only limited labeled samples are available due to expensive annotation costs over…

Machine Learning · Computer Science 2019-11-19 Yifan Zhang , Ying Wei , Peilin Zhao , Shuaicheng Niu , Qingyao Wu , Mingkui Tan , Junzhou Huang

With promising results of machine learning based models in computer vision, applications on medical imaging data have been increasing exponentially. However, generalizations to complex real-world clinical data is a persistent problem. Deep…

Computer Vision and Pattern Recognition · Computer Science 2020-07-27 Nooshin Mojab , Vahid Noroozi , Darvin Yi , Manoj Prabhakar Nallabothula , Abdullah Aleem , Phillip S. Yu , Joelle A. Hallak

Clinical machine learning models experience significantly degraded performance in datasets not seen during training, e.g., new hospitals or populations. Recent developments in domain generalization offer a promising solution to this problem…

Machine Learning · Computer Science 2021-04-16 Haoran Zhang , Natalie Dullerud , Laleh Seyyed-Kalantari , Quaid Morris , Shalmali Joshi , Marzyeh Ghassemi

Applying an object detector, which is neither trained nor fine-tuned on data close to the final application, often leads to a substantial performance drop. In order to overcome this problem, it is necessary to consider a shift between…

Computer Vision and Pattern Recognition · Computer Science 2020-05-27 Alexey Abramov , Christopher Bayer , Claudio Heller

Medical imaging datasets often vary due to differences in acquisition protocols, patient demographics, and imaging devices. These variations in data distribution, known as domain shift, present a significant challenge in adapting imaging…

Computer Vision and Pattern Recognition · Computer Science 2026-03-16 Doron Serebro , Tammy Riklin-Raviv

Labeling medical images is a major bottleneck in the field of medical imaging, as it requires domain-specific expertise, and it gets further complicated due to variability across different medical centers and different imaging devices. Such…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Sapna Sachan , Rakesh Kumar Sanodiya , Amulya Kumar Mahto

Skin cancer is a serious and potentially fatal disease caused by DNA damage. Early detection significantly increases survival rates, making accurate diagnosis crucial. In this groundbreaking study, we present a hybrid framework based on…

Image and Video Processing · Electrical Eng. & Systems 2025-03-26 Maksuda Akter , Rabea Khatun , Md. Alamin Talukder , Md. Manowarul Islam , Md. Ashraf Uddin

Deep learning (DL) techniques are highly effective for defect detection from images. Training DL classification models, however, requires vast amounts of labeled data which is often expensive to collect. In many cases, not only the…

Computer Vision and Pattern Recognition · Computer Science 2023-06-02 Adrian Shuai Li , Elisa Bertino , Rih-Teng Wu , Ting-Yan Wu

Each year, the lack of efficient data standardization and interoperability in cancer care contributes to the severe lack of timely and effective diagnosis, while constantly adding to the burden of cost, with cancer costs nationally reaching…

Machine Learning · Computer Science 2024-10-29 Aarsh Shekhar , Mincheol Kim

Stain normalization algorithms aim to transform the color and intensity characteristics of a source multi-gigapixel histology image to match those of a target image, mitigating inconsistencies in the appearance of stains used to highlight…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Robert Jewsbury , Ruoyu Wang , Abhir Bhalerao , Nasir Rajpoot , Quoc Dang Vu

Leukemia diagnosis and monitoring rely increasingly on high-throughput image data, yet conventional clustering methods lack the flexibility to accommodate evolving cellular patterns and quantify uncertainty in real time. We introduce…

Machine Learning · Computer Science 2025-12-01 Marco Aruta , Ciro Listone , Giuseppe Murano , Aniello Murano

Label-free chemical imaging holds significant promise for improving digital pathology workflows, but data acquisition speed remains a limiting factor. To address this gap, we propose an adaptive strategy-initially scan the low information…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Ji-Hun Oh , Kianoush Falahkheirkhah , Rohit Bhargava

Test-time adaptation (TTA) refers to adapting a trained model to a new domain during testing. Existing TTA techniques rely on having multiple test images from the same domain, yet this may be impractical in real-world applications such as…

Computer Vision and Pattern Recognition · Computer Science 2024-02-19 Haoyu Dong , Nicholas Konz , Hanxue Gu , Maciej A. Mazurowski

The complexities inherent to leukemia, multifaceted cancer affecting white blood cells, pose considerable diagnostic and treatment challenges, primarily due to reliance on laborious morphological analyses and expert judgment that are…

Accurate detection and segmentation of anatomical structures from ultrasound images are crucial for clinical diagnosis and biometric measurements. Although ultrasound imaging has been widely used with superiorities such as low cost and…

Computer Vision and Pattern Recognition · Computer Science 2016-07-08 Hao Chen , Yefeng Zheng , Jin-Hyeong Park , Pheng-Ann Heng , S. Kevin Zhou

We propose a unified cross-domain transfer learning framework that leverages knowledge from multiple heterogeneous medical imaging datasets to improve performance across segmentation, classification, and object detection tasks. Our approach…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Ceausescu Ciprian-Mihai , Anghelina Ion-Marian , Alexe Dumitru-Bogdan

Deep learning models often achieve expert-level accuracy in medical image classification but suffer from a critical flaw: semantic incoherence. These high-confidence mistakes that are semantically incoherent (e.g., classifying a malignant…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Abolfazl Mohammadi-Seif , Ricardo Baeza-Yates