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This paper addresses the problem of liver cancer segmentation in Whole Slide Image (WSI). We propose a multi-scale image processing method based on automatic end-to-end deep neural network algorithm for segmentation of cancer area. A…

Image and Video Processing · Electrical Eng. & Systems 2020-07-29 Yanbo Feng , Adel Hafiane , Hélène Laurent

The whole slide histopathology images (WSIs) play a critical role in gastric cancer diagnosis. However, due to the large scale of WSIs and various sizes of the abnormal area, how to select informative regions and analyze them are quite…

Computer Vision and Pattern Recognition · Computer Science 2020-10-14 Shujun Wang , Yaxi Zhu , Lequan Yu , Hao Chen , Huangjing Lin , Xiangbo Wan , Xinjuan Fan , Pheng-Ann Hen

High-resolution (HR) MRI scans obtained from research-grade medical centers provide precise information about imaged tissues. However, routine clinical MRI scans are typically in low-resolution (LR) and vary greatly in contrast and spatial…

Image and Video Processing · Electrical Eng. & Systems 2023-08-25 Jueqi Wang , Jacob Levman , Walter Hugo Lopez Pinaya , Petru-Daniel Tudosiu , M. Jorge Cardoso , Razvan Marinescu

The objective of image super-resolution is to generate clean and high-resolution images from degraded versions. Recent advancements in diffusion modeling have led to the emergence of various image super-resolution techniques that leverage…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Haolan Chen , Jinhua Hao , Kai Zhao , Kun Yuan , Ming Sun , Chao Zhou , Wei Hu

In the medical domain, acquiring large datasets is challenging due to both accessibility issues and stringent privacy regulations. Consequently, data availability and privacy protection are major obstacles to applying machine learning in…

Image and Video Processing · Electrical Eng. & Systems 2025-07-02 Wenwu Tang , Khaled Seyam , Bin Yang

Understanding the relationship between pathological and healthy brain structures is fundamental to neuroimaging, connecting disease diagnosis and detection with modeling, prediction, and treatment planning. However, paired…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Jun Wang , Peirong Liu

Deep generative models have demonstrated remarkable success in medical image synthesis. However, ensuring conditioning faithfulness and high-quality synthetic images for direct or counterfactual generation remains a challenge. In this work,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Fangrui Huang , Alan Wang , Binxu Li , Bailey Trang , Ridvan Yesiloglu , Tianyu Hua , Wei Peng , Ehsan Adeli

Histology slide digitization is becoming essential for telepathology (remote consultation), knowledge sharing (education), and using the state-of-the-art artificial intelligence algorithms (augmented/automated end-to-end clinical…

Image and Video Processing · Electrical Eng. & Systems 2024-05-15 Talat Zehra , Joseph Marino , Wendy Wang , Grigoriy Frantsuzov , Saad Nadeem

Computed Tomography (CT) technology reduces radiation haz-ards to the human body through sparse sampling, but fewer sampling angles pose challenges for image reconstruction. Score-based generative models are widely used in sparse-view CT…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Junyan Zhang , Mengxiao Geng , Pinhuang Tan , Yi Liu , Zhili Liu , Bin Huang , Qiegen Liu

As a pragmatic data augmentation tool, data synthesis has generally returned dividends in performance for deep learning based medical image analysis. However, generating corresponding segmentation masks for synthetic medical images is…

Image and Video Processing · Electrical Eng. & Systems 2023-03-23 Xiaodan Xing , Giorgos Papanastasiou , Simon Walsh , Guang Yang

Automatic disease image grading is a significant application of artificial intelligence for healthcare, enabling faster and more accurate patient assessments. However, domain shifts, which are exacerbated by data imbalance, introduce bias…

Computer Vision and Pattern Recognition · Computer Science 2025-05-02 Shuo Tong , Shangde Gao , Ke Liu , Zihang Huang , Hongxia Xu , Haochao Ying , Jian Wu

Estimating and disentangling epistemic uncertainty, uncertainty that is reducible with more training data, and aleatoric uncertainty, uncertainty that is inherent to the task at hand, is critically important when applying machine learning…

Machine Learning · Computer Science 2024-11-08 Matthew A. Chan , Maria J. Molina , Christopher A. Metzler

Latent Diffusion Models (LDMs) enable high-quality image synthesis while avoiding excessive compute demands by training a diffusion model in a compressed lower-dimensional latent space. Here, we apply the LDM paradigm to high-resolution…

Computer Vision and Pattern Recognition · Computer Science 2023-12-29 Andreas Blattmann , Robin Rombach , Huan Ling , Tim Dockhorn , Seung Wook Kim , Sanja Fidler , Karsten Kreis

Whole Slide Image (WSI) analysis plays a crucial role in modern digital pathology, enabling large-scale feature extraction from tissue samples. However, traditional feature extraction pipelines based on tools like CellProfiler often involve…

Image and Video Processing · Electrical Eng. & Systems 2025-01-13 Yuechen Yang , Yu Wang , Tianyuan Yao , Ruining Deng , Mengmeng Yin , Shilin Zhao , Haichun Yang , Yuankai Huo

Histopathology can help clinicians make accurate diagnoses, determine disease prognosis, and plan appropriate treatment strategies. As deep learning techniques prove successful in the medical domain, the primary challenges become limited…

Computer Vision and Pattern Recognition · Computer Science 2024-07-11 Zhe Li , Bernhard Kainz

Federated learning (FL) has emerged as a promising approach for collaborative medical image analysis, enabling multiple institutions to build robust predictive models while preserving sensitive patient data. In the context of Whole Slide…

Image and Video Processing · Electrical Eng. & Systems 2025-06-19 Haolong Jin , Shenglin Liu , Cong Cong , Qingmin Feng , Yongzhi Liu , Lina Huang , Yingzi Hu

U-shaped networks and its variants have demonstrated exceptional results for medical image segmentation. In this paper, we propose a novel dual self-distillation (DSD) framework in U-shaped networks for volumetric medical image…

Image and Video Processing · Electrical Eng. & Systems 2025-05-05 Soumyanil Banerjee , Nicholas Summerfield , Ming Dong , Carri Glide-Hurst

Medical image segmentation is a critical step in computer-aided diagnosis, and convolutional neural networks are popular segmentation networks nowadays. However, the inherent local operation characteristics make it difficult to focus on the…

Computer Vision and Pattern Recognition · Computer Science 2023-05-18 Fenghe Tang , Jianrui Ding , Lingtao Wang , Min Xian , Chunping Ning

Image segmentation is crucial in many computational pathology pipelines, including accurate disease diagnosis, subtyping, outcome, and survivability prediction. The common approach for training a segmentation model relies on a pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Sachin Kumar Danisetty , Alexandros Graikos , Srikar Yellapragada , Dimitris Samaras

We present Defocusing Microscopy (DM), a bright-field optical microscopy technique able to perform total 3D imaging of transparent objects. By total 3D imaging we mean the determination of the actual shapes of the upper and lower surfaces…

Biological Physics · Physics 2015-06-19 P. M. S. Roma , L. Siman , F. T. Amaral , U. Agero , O. N. Mesquita