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The causal relationships between biomarkers are essential for disease diagnosis and medical treatment planning. One notable application is Alzheimer's disease (AD) diagnosis, where certain biomarkers may influence the presence of others,…

Information Retrieval · Computer Science 2025-06-13 Xiaofan Zhou , Liangjie Huang , Pinyang Cheng , Wenpen Yin , Rui Zhang , Wenrui Hao , Lu Cheng

Retrieval-Augmented Generation (RAG) has significantly mitigated the hallucinations of Large Language Models (LLMs) by grounding the generation with external knowledge. Recent extensions of RAG to graph-based retrieval offer a promising…

Machine Learning · Computer Science 2025-09-23 Jialin Chen , Houyu Zhang , Seongjun Yun , Alejandro Mottini , Rex Ying , Xiang Song , Vassilis N. Ioannidis , Zheng Li , Qingjun Cui

Large language models (LLMs) like ChatGPT demonstrate the remarkable progress of artificial intelligence. However, their tendency to hallucinate -- generate plausible but false information -- poses a significant challenge. This issue is…

Computation and Language · Computer Science 2024-06-13 Philip Feldman , James R. Foulds , Shimei Pan

The advent of large language models (LLMs) has allowed numerous applications, including the generation of queried responses, to be leveraged in chatbots and other conversational assistants. Being trained on a plethora of data, LLMs often…

Computation and Language · Computer Science 2025-05-16 Deeksha Prahlad , Chanhee Lee , Dongha Kim , Hokeun Kim

Large language models (LLMs) have demonstrated strong capabilities in medical question answering; however, purely parametric models often suffer from knowledge gaps and limited factual grounding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2026-04-09 Nusrat Sultana , Abdullah Muhammad Moosa , Kazi Afzalur Rahman , Sajal Chandra Banik

Retrieval-Augmented Generation (RAG) models are designed to incorporate external knowledge, reducing hallucinations caused by insufficient parametric (internal) knowledge. However, even with accurate and relevant retrieved content, RAG…

Computation and Language · Computer Science 2025-01-22 Zhongxiang Sun , Xiaoxue Zang , Kai Zheng , Yang Song , Jun Xu , Xiao Zhang , Weijie Yu , Yang Song , Han Li

Retrieval-augmented generation (RAG) appears as a promising method to alleviate the "hallucination" problem in large language models (LLMs), since it can incorporate external traceable resources for response generation. The essence of RAG…

Computation and Language · Computer Science 2024-10-16 Haosheng Qian , Yixing Fan , Ruqing Zhang , Jiafeng Guo

Retrieval-augmented generation (RAG) is increasingly recognized as an effective approach to mitigating the hallucination of large language models (LLMs) through the integration of external knowledge. While numerous efforts, most studies…

Computation and Language · Computer Science 2025-10-10 Shuo Yu , Mingyue Cheng , Qi Liu , Daoyu Wang , Jiqian Yang , Jie Ouyang , Yucong Luo , Chenyi Lei , Enhong Chen

Large language models (LLMs) have achieved strong empirical performance in various fields, benefiting from their huge amount of parameters that store knowledge. However, LLMs still suffer from several key issues, such as hallucination…

Computation and Language · Computer Science 2026-05-20 Shangyu Wu , Ying Xiong , Yufei Cui , Haolun Wu , Can Chen , Ye Yuan , Lianming Huang , Xue Liu , Tei-Wei Kuo , Nan Guan , Chun Jason Xue

Large Language Models (LLMs) are being adopted at an unprecedented rate, yet still face challenges in knowledge-intensive domains like biomedicine. Solutions such as pre-training and domain-specific fine-tuning add substantial computational…

Electronic health records (EHRs) are long, noisy, and often redundant, posing a major challenge for the clinicians who must navigate them. Large language models (LLMs) offer a promising solution for extracting and reasoning over this…

Computation and Language · Computer Science 2025-08-21 Skatje Myers , Dmitriy Dligach , Timothy A. Miller , Samantha Barr , Yanjun Gao , Matthew Churpek , Anoop Mayampurath , Majid Afshar

Graph-based retrieval-augmented generation (Graph-based RAG) has demonstrated significant potential in enhancing Large Language Models (LLMs) with structured knowledge. However, existing methods face three critical challenges: Inaccurate…

Machine Learning · Computer Science 2026-03-18 Yubo Wang , Haoyang Li , Fei Teng , Lei Chen

Large Language Models (LLMs) have shown versatility in various Natural Language Processing (NLP) tasks, including their potential as effective question-answering systems. However, to provide precise and relevant information in response to…

Computation and Language · Computer Science 2024-09-09 Sriram Veturi , Saurabh Vaichal , Reshma Lal Jagadheesh , Nafis Irtiza Tripto , Nian Yan

Large Language Models (LLMs) have demonstrated significant potential in medical Question Answering (QA), yet they remain prone to hallucinations and ungrounded reasoning, limiting their reliability in high-stakes clinical scenarios. While…

Information Retrieval · Computer Science 2026-01-09 Jessica Ryan , Alexander I. Gumilang , Robert Wiliam , Derwin Suhartono

Recently, Retrieval-Augmented Generation (RAG) has achieved remarkable success in addressing the challenges of Large Language Models (LLMs) without necessitating retraining. By referencing an external knowledge base, RAG refines LLM…

Artificial Intelligence · Computer Science 2024-09-11 Boci Peng , Yun Zhu , Yongchao Liu , Xiaohe Bo , Haizhou Shi , Chuntao Hong , Yan Zhang , Siliang Tang

Retrieval-augmented generation (RAG) techniques have emerged as a promising solution to enhance the reliability of large language models (LLMs) by addressing issues like hallucinations, outdated knowledge, and domain adaptation. In…

Computation and Language · Computer Science 2025-01-28 Weihang Su , Yichen Tang , Qingyao Ai , Junxi Yan , Changyue Wang , Hongning Wang , Ziyi Ye , Yujia Zhou , Yiqun Liu

The data and compute requirements of current language modeling technology pose challenges for the processing and analysis of low-resource languages. Declarative linguistic knowledge has the potential to partially bridge this data scarcity…

Computation and Language · Computer Science 2024-10-02 Bhargav Shandilya , Alexis Palmer

Retrieval-Augmented Generation (RAG) was introduced to enhance the capabilities of Large Language Models (LLMs) beyond their encoded prior knowledge. This is achieved by providing LLMs with an external source of knowledge, which helps…

Computation and Language · Computer Science 2026-03-11 Hazem Amamou , Stéphane Gagnon , Alan Davoust , Anderson R. Avila

Medical question answering (QA) requires extensive access to domain-specific knowledge. A promising direction is to enhance large language models (LLMs) with external knowledge retrieved from medical corpora or parametric knowledge stored…

Computation and Language · Computer Science 2025-10-22 Lei Li , Xiao Zhou , Yingying Zhang , Xian Wu

Large language models (LLMs) inherently display hallucinations since the precision of generated texts cannot be guaranteed purely by the parametric knowledge they include. Although retrieval-augmented generation (RAG) systems enhance the…

Artificial Intelligence · Computer Science 2025-02-18 Bingyu Wan , Fuxi Zhang , Zhongpeng Qi , Jiayi Ding , Jijun Li , Baoshi Fan , Yijia Zhang , Jun Zhang