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Drug discovery is a critical task in biomedical natural language processing (NLP), yet explainable drug discovery remains underexplored. Meanwhile, large language models (LLMs) have shown remarkable abilities in natural language…

Computation and Language · Computer Science 2025-02-28 Kai Zhang , Rui Zhu , Shutian Ma , Jingwei Xiong , Yejin Kim , Fabricio Murai , Xiaozhong Liu

Large language models (LLMs) are increasingly being recognised as valuable knowledge communication tools in many industries. However, their application in livestock farming remains limited, being constrained by several factors not least the…

Artificial Intelligence · Computer Science 2025-09-15 Nana Han , Dong Liu , Tomas Norton

Naive Retrieval-Augmented Generation (RAG) focuses on individual documents during retrieval and, as a result, falls short in handling networked documents which are very popular in many applications such as citation graphs, social media, and…

Machine Learning · Computer Science 2025-07-15 Yuntong Hu , Zhihan Lei , Zheng Zhang , Bo Pan , Chen Ling , Liang Zhao

Despite the impressive advancements of Large Language Models (LLMs) in generating text, they are often limited by the knowledge contained in the input and prone to producing inaccurate or hallucinated content. To tackle these issues,…

Information Retrieval · Computer Science 2024-05-29 Yu Wang , Nedim Lipka , Ruiyi Zhang , Alexa Siu , Yuying Zhao , Bo Ni , Xin Wang , Ryan Rossi , Tyler Derr

Large Language Models (LLMs) showcase remarkable abilities, yet they struggle with limitations such as hallucinations, outdated knowledge, opacity, and inexplicable reasoning. To address these challenges, Retrieval-Augmented Generation…

Computation and Language · Computer Science 2024-10-03 Sourav Verma

Large Language Models (LLMs) have been increasingly adopted for health-related tasks, yet their performance in depression detection remains limited when relying solely on text input. While Retrieval-Augmented Generation (RAG) typically…

Audio and Speech Processing · Electrical Eng. & Systems 2025-05-26 Xiangyu Zhang , Hexin Liu , Qiquan Zhang , Beena Ahmed , Julien Epps

Drug repurposing plays a critical role in accelerating treatment discovery, especially for complex and rare diseases. Biomedical knowledge graphs (KGs), which encode rich clinical associations, have been widely adopted to support this task.…

Computation and Language · Computer Science 2025-10-15 Chengrui Xiang , Tengfei Ma , Xiangzheng Fu , Yiping Liu , Bosheng Song , Xiangxiang Zeng

Large language models (LLMs) exhibit extensive medical knowledge but are prone to hallucinations and inaccurate citations, which pose a challenge to their clinical adoption and regulatory compliance. Current methods, such as Retrieval…

Retrieval Augmented Generation (RAG) systems have emerged as a powerful method for enhancing large language models (LLMs) with up-to-date information. However, the retrieval step in RAG can sometimes surface documents containing…

Computation and Language · Computer Science 2025-04-02 Vignesh Gokul , Srikanth Tenneti , Alwarappan Nakkiran

Medical question answering requires extensive access to specialized conceptual knowledge. The current paradigm, Retrieval-Augmented Generation (RAG), acquires expertise medical knowledge through large-scale corpus retrieval and uses this…

Computation and Language · Computer Science 2025-02-20 Sichu Liang , Linhai Zhang , Hongyu Zhu , Wenwen Wang , Yulan He , Deyu Zhou

Large Language Models (LLMs) have gained widespread adoption in various natural language processing tasks, including question answering and dialogue systems. However, a major drawback of LLMs is the issue of hallucination, where they…

Computation and Language · Computer Science 2024-07-08 Yuyan Chen , Qiang Fu , Yichen Yuan , Zhihao Wen , Ge Fan , Dayiheng Liu , Dongmei Zhang , Zhixu Li , Yanghua Xiao

Retrieval-Augmented Generation (RAG) improves large language models (LLMs) by retrieving relevant information from external sources and has been widely adopted for text-based tasks. For structured data, such as knowledge graphs, Graph…

Information Retrieval · Computer Science 2026-03-05 Haoyu Han , Li Ma , Yu Wang , Harry Shomer , Yongjia Lei , Zhisheng Qi , Kai Guo , Zhigang Hua , Bo Long , Hui Liu , Charu C. Aggarwal , Jiliang Tang

Large Language Models (LLMs) show potential for medical applications but often lack specialized clinical knowledge. Retrieval Augmented Generation (RAG) allows customization with domain-specific information, making it suitable for…

Electronic Health Records (EHRs) and routine documentation practices play a vital role in patients' daily care, providing a holistic record of health, diagnoses, and treatment. However, complex and verbose EHR narratives overload healthcare…

Computation and Language · Computer Science 2025-02-26 Yanjun Gao , Ruizhe Li , Emma Croxford , John Caskey , Brian W Patterson , Matthew Churpek , Timothy Miller , Dmitriy Dligach , Majid Afshar

Large Language Models (LLMs) have shown remarkable capabilities across diverse tasks, yet they face inherent limitations such as constrained parametric knowledge and high retraining costs. Retrieval-Augmented Generation (RAG) augments the…

Information Retrieval · Computer Science 2025-08-26 Leqian Li , Dianxi Shi , Jialu Zhou , Xinyu Wei , Mingyue Yang , Songchang Jin , Shaowu Yang

Retrieval-augmented generation (RAG) is key to enhancing large language models (LLMs) to systematically access richer factual knowledge. Yet, using RAG brings intrinsic challenges, as LLMs must deal with potentially conflicting knowledge,…

Computation and Language · Computer Science 2025-04-08 Leonardo Ranaldi , Federico Ranaldi , Fabio Massimo Zanzotto , Barry Haddow , Alexandra Birch

Retrieval augmented generation (RAG) combines the generative abilities of large language models (LLMs) with external knowledge sources to provide more accurate and up-to-date responses. Recent RAG advancements focus on improving retrieval…

With the advancement of large language models (LLMs), the biomedical domain has seen significant progress and improvement in multiple tasks such as biomedical question answering, lay language summarization of the biomedical literature,…

Information Retrieval · Computer Science 2024-12-17 Deepak Gupta , Dina Demner-Fushman , William Hersh , Steven Bedrick , Kirk Roberts

Large Language Models (LLMs) are capable of natural language understanding and generation. But they face challenges such as hallucination and outdated knowledge. Fine-tuning is one possible solution, but it is resource-intensive and must be…

Computation and Language · Computer Science 2025-07-01 Shadman Sobhan , Mohammad Ariful Haque

Large language models (LLMs) often need to incorporate external knowledge to solve theme-specific problems. Retrieval-augmented generation (RAG) has shown its high promise, empowering LLMs to generate more qualified responses with retrieved…

Machine Learning · Computer Science 2025-08-05 Jimeng Shi , Sizhe Zhou , Bowen Jin , Wei Hu , Runchu Tian , Shaowen Wang , Giri Narasimhan , Jiawei Han
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