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We present CardiacGen, a Deep Learning framework for generating synthetic but physiologically plausible cardiac signals like ECG. Based on the physiology of cardiovascular system function, we propose a modular hierarchical generative model…

Machine Learning · Computer Science 2022-11-16 Tushar Agarwal , Emre Ertin

Although machine learning has been successfully used to propose novel molecules that satisfy desired properties, it is still challenging to explore a large chemical space efficiently. In this paper, we present a conditional molecular design…

Machine Learning · Computer Science 2019-04-02 Seokho Kang , Kyunghyun Cho

Deep learning-based graph generation approaches have remarkable capacities for graph data modeling, allowing them to solve a wide range of real-world problems. Making these methods able to consider different conditions during the generation…

Machine Learning · Computer Science 2023-01-11 Faezeh Faez , Negin Hashemi Dijujin , Mahdieh Soleymani Baghshah , Hamid R. Rabiee

Causal generative modeling is essential for developing reliable and transparent AI systems capable of counterfactual reasoning. While existing approaches focus on integrating causal constraints during the training of generative models, they…

Machine Learning · Computer Science 2026-05-25 Aneesh Komanduri , Xintao Wu

Generative Foundation Models (GFMs) have achieved remarkable success in producing high-quality synthetic data for images and text. However, their application to tabular data presents significant challenges due to the heterogeneous nature of…

Machine Learning · Computer Science 2025-11-27 Xiaofeng Lin , Chenheng Xu , Matthew Yang , Guang Cheng

Individual-level data (microdata) that characterizes a population, is essential for studying many real-world problems. However, acquiring such data is not straightforward due to cost and privacy constraints, and access is often limited to…

Machine Learning · Computer Science 2022-12-13 Angeela Acharya , Siddhartha Sikdar , Sanmay Das , Huzefa Rangwala

Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has become a cornerstone technology in clinical microbiology, enabling rapid and accurate microbial identification. However, the development of…

The prevalence of missing values in data science poses a substantial risk to any further analyses. Despite a wealth of research, principled nonparametric methods to deal with general non-monotone missingness are still scarce. Instead,…

Machine Learning · Statistics 2026-05-04 Gitte Kremling , Jeffrey Näf , Johannes Lederer

The generation of synthetic financial data is a critical technology in the financial domain, addressing challenges posed by limited data availability. Traditionally, statistical models have been employed to generate synthetic data. However,…

Computational Finance · Quantitative Finance 2025-03-07 Yuki Tanaka , Ryuji Hashimoto , Takehiro Takayanagi , Zhe Piao , Yuri Murayama , Kiyoshi Izumi

Deep generative models open new avenues for simulating realistic genomic data while preserving privacy and addressing data accessibility constraints. While previous studies have primarily focused on generating gene expression or haplotype…

Genomics · Quantitative Biology 2025-08-14 Sihan Xie , Thierry Tribout , Didier Boichard , Blaise Hanczar , Julien Chiquet , Eric Barrey

Cellular differentiation is governed by gene regulatory networks, the high-dimensional stochastic biochemical systems that determine the transcriptional landscape and mediate cellular responses to signals and perturbations. Although…

Molecular Networks · Quantitative Biology 2026-04-29 Suryanarayana Maddu , Victor Chardès , Michael J. Shelley

Although deep learning has achieved impressive advances in transient stability assessment of power systems, the insufficient and imbalanced samples still trap the training effect of the data-driven methods. This paper proposes a…

Machine Learning · Computer Science 2021-12-17 Gengshi Han , Shunyu Liu , Kaixuan Chen , Na Yu , Zunlei Feng , Mingli Song

Single-cell RNA sequencing (scRNA-seq) data simulation is limited by classical methods that rely on linear correlations, failing to capture the intrinsic, nonlinear dependencies. No existing simulator jointly models gene-gene and cell-cell…

Quantitative Methods · Quantitative Biology 2025-12-22 Selim Romero , Vignesh S. Kumar , Robert S. Chapkin , James J. Cai

Recent advancements in generative models have unlocked the capabilities to render photo-realistic data in a controllable fashion. Trained on the real data, these generative models are capable of producing realistic samples with minimal to…

Computer Vision and Pattern Recognition · Computer Science 2024-06-13 Abhay Rawat , Shubham Dokania , Astitva Srivastava , Shuaib Ahmed , Haiwen Feng , Rahul Tallamraju

Data synthesis is gaining momentum as a privacy-enhancing technology. While single-table tabular data generation has seen considerable progress, current methods for multi-table data often lack the flexibility and expressiveness needed to…

Machine Learning · Computer Science 2025-11-11 Davide Scassola , Sebastiano Saccani , Luca Bortolussi

Recent advances in generative artificial intelligence have had a significant impact on diverse domains spanning computer vision, natural language processing, and drug discovery. This work extends the reach of generative models into physical…

Machine Learning · Computer Science 2024-10-22 Christian Jacobsen , Yilin Zhuang , Karthik Duraisamy

High-fidelity generative models are increasingly needed in privacy-sensitive scenarios, where access to data is severely restricted due to regulatory and copyright constraints. This scarcity hampers model development--ironically, in…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Xuemei Jia , Jiawei Du , Hui Wei , Jun Chen , Joey Tianyi Zhou , Zheng Wang

Multistep inference is a bottleneck for real-time generative speech enhancement because flow- and diffusion-based systems learn an instantaneous velocity field and therefore rely on iterative ordinary differential equation (ODE) solvers. We…

Sound · Computer Science 2026-03-05 Duojia Li , Shenghui Lu , Hongchen Pan , Zongyi Zhan , Qingyang Hong , Lin Li

Continual learning is essential for real-world deployment when there is a need to quickly adapt the model to new tasks without forgetting knowledge of old tasks. Existing work on continual sequence generation either always reuses existing…

Computation and Language · Computer Science 2022-04-06 Yanzhe Zhang , Xuezhi Wang , Diyi Yang

Deep generative models (DGM) are neural networks with many hidden layers trained to approximate complicated, high-dimensional probability distributions using a large number of samples. When trained successfully, we can use the DGMs to…

Machine Learning · Computer Science 2021-04-13 Lars Ruthotto , Eldad Haber