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Large language models (LLMs), such as GPT-4, have demonstrated remarkable capabilities across a wide range of tasks, including health applications. In this paper, we study how LLMs can be used to scale biomedical knowledge curation. We find…

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

Large language models (LLMs) excel at clinical information extraction but their computational demands limit practical deployment. Knowledge distillation--the process of transferring knowledge from larger to smaller models--offers a…

Computation and Language · Computer Science 2025-01-03 Karthik S. Vedula , Annika Gupta , Akshay Swaminathan , Ivan Lopez , Suhana Bedi , Nigam H. Shah

This paper introduces an approach that combines the language reasoning capabilities of large language models (LLMs) with the benefits of local training to tackle complex, domain-specific tasks. Specifically, the authors demonstrate their…

Computation and Language · Computer Science 2023-08-04 V. K. Cody Bumgardner , Aaron Mullen , Sam Armstrong , Caylin Hickey , Jeff Talbert

This study evaluates causal reasoning in large language models (LLMs) using 99 clinically grounded laboratory test scenarios aligned with Pearl's Ladder of Causation: association, intervention, and counterfactual reasoning. We examined…

Artificial Intelligence · Computer Science 2025-09-23 Balu Bhasuran , Mattia Prosperi , Karim Hanna , John Petrilli , Caretia JeLayne Washington , Zhe He

The validity of medical studies based on real-world clinical data, such as observational studies, depends on critical assumptions necessary for drawing causal conclusions about medical interventions. Many published studies are flawed…

Artificial Intelligence · Computer Science 2024-07-30 Ahmed Alaa , Rachael V. Phillips , Emre Kıcıman , Laura B. Balzer , Mark van der Laan , Maya Petersen

The causal capabilities of large language models (LLMs) are a matter of significant debate, with critical implications for the use of LLMs in societally impactful domains such as medicine, science, law, and policy. We conduct a "behavorial"…

Artificial Intelligence · Computer Science 2024-08-21 Emre Kıcıman , Robert Ness , Amit Sharma , Chenhao Tan

Recent advances in natural language processing (NLP) have been driven bypretrained language models like BERT, RoBERTa, T5, and GPT. Thesemodels excel at understanding complex texts, but biomedical literature, withits domain-specific…

Computation and Language · Computer Science 2025-07-28 K. Sahit Reddy , N. Ragavenderan , Vasanth K. , Ganesh N. Naik , Vishalakshi Prabhu , Nagaraja G. S

Large language models (LLMs) have recently showcased remarkable capabilities, spanning a wide range of tasks and applications, including those in the medical domain. Models like GPT-4 excel in medical question answering but may face…

Computation and Language · Computer Science 2025-07-02 Bowen Wang , Jiuyang Chang , Yiming Qian , Guoxin Chen , Junhao Chen , Zhouqiang Jiang , Jiahao Zhang , Yuta Nakashima , Hajime Nagahara

Biomedical literature often uses complex language and inaccessible professional terminologies. That is why simplification plays an important role in improving public health literacy. Applying Natural Language Processing (NLP) models to…

Computation and Language · Computer Science 2024-03-19 Zihao Li , Samuel Belkadi , Nicolo Micheletti , Lifeng Han , Matthew Shardlow , Goran Nenadic

Large language models (LLMs) can simulate clinical reasoning based on natural language prompts, but their utility in ophthalmology is largely unexplored. This study evaluated GPT-4's ability to interpret structured textual descriptions of…

Computation and Language · Computer Science 2025-07-03 Cindy Lie Tabuse , David Restepo , Carolina Gracitelli , Fernando Korn Malerbi , Caio Regatieri , Luis Filipe Nakayama

Clinical texts, represented in electronic medical records (EMRs), contain rich medical information and are essential for disease prediction, personalised information recommendation, clinical decision support, and medication pattern mining…

Computation and Language · Computer Science 2023-10-10 Hangyu Tu , Lifeng Han , Goran Nenadic

Large language models (LLMs) have made significant progress in various domains, including healthcare. However, the specialized nature of clinical language understanding tasks presents unique challenges and limitations that warrant further…

Computation and Language · Computer Science 2023-08-01 Yuqing Wang , Yun Zhao , Linda Petzold

We evaluate the ability of large language models (LLMs) to infer causal relations from natural language. Compared to traditional natural language processing and deep learning techniques, LLMs show competitive performance in a benchmark of…

Artificial Intelligence · Computer Science 2023-12-25 Alessandro Antonucci , Gregorio Piqué , Marco Zaffalon

One of the major barriers to using large language models (LLMs) in medicine is the perception they use uninterpretable methods to make clinical decisions that are inherently different from the cognitive processes of clinicians. In this…

Computation and Language · Computer Science 2023-08-15 Thomas Savage , Ashwin Nayak , Robert Gallo , Ekanath Rangan , Jonathan H Chen

There is enormous enthusiasm and concerns in using large language models (LLMs) in healthcare, yet current assumptions are all based on general-purpose LLMs such as ChatGPT. This study develops a clinical generative LLM, GatorTronGPT, using…

Large language models (LLMs) are increasingly used to extract structured information from free-text clinical records, but prior work often focuses on single tasks, limited models, and English-language reports. We evaluated 15 open-weight…

The escalating volume of collected healthcare textual data presents a unique challenge for automated Multi-Label Text Classification (MLTC), which is primarily due to the scarcity of annotated texts for training and their nuanced nature.…

Computation and Language · Computer Science 2025-03-04 Hajar Sakai , Sarah S. Lam

Chronic diseases such as diabetes are the leading causes of morbidity and mortality worldwide. Numerous research studies have been attempted with various deep learning models in diagnosis. However, most previous studies had certain…

This paper conducts a comprehensive investigation into applying large language models, particularly on BioBERT, in healthcare. It begins with thoroughly examining previous natural language processing (NLP) approaches in healthcare, shedding…

Artificial Intelligence · Computer Science 2023-10-13 Shyni Sharaf , V. S. Anoop
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