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Systems biology and systems neurophysiology in particular have recently emerged as powerful tools for a number of key applications in the biomedical sciences. Nevertheless, such models are often based on complex combinations of multiscale…

Neural and Evolutionary Computing · Computer Science 2022-09-27 Matteo Ferrante , Andera Duggento , Nicola Toschi

Recent advancements in physics-informed neural networks (PINNs) and their variants have garnered substantial focus from researchers due to their effectiveness in solving both forward and inverse problems governed by differential equations.…

Machine Learning · Computer Science 2026-01-06 Shivani Saini , Ramesh Kumar Vats , Arup Kumar Sahoo

Physics-informed neural network (PINN) is a powerful emerging method for studying forward-inverse problems of partial differential equations (PDEs), even from limited sample data. Variable coefficient PDEs, which model real-world phenomena,…

Computational Physics · Physics 2025-03-07 Hui-Juan Zhou , Yong Chen

The simulation of power system dynamics poses a computationally expensive task. Considering the growing uncertainty of generation and demand patterns, thousands of scenarios need to be continuously assessed to ensure the safety of power…

Systems and Control · Electrical Eng. & Systems 2023-11-13 Jochen Stiasny , Spyros Chatzivasileiadis

In the field of pharmacokinetics and pharmacodynamics (PKPD) modeling, which plays a pivotal role in the drug development process, traditional models frequently encounter difficulties in fully encapsulating the complexities of drug…

Quantitative Methods · Quantitative Biology 2024-09-23 Nazanin Ahmadi Daryakenari , Shupeng Wang , George Karniadakis

Physics-Informed Neural Networks (PINNs) are effective methods for solving inverse problems and discovering governing equations from observational data. However, their performance degrades significantly under complex measurement noise and…

Machine Learning · Computer Science 2026-02-04 Hankyeol Kim , Pilsung Kang

This paper aims to provide a machine learning framework to simulate two-phase flow in porous media. The proposed algorithm is based on Physics-informed neural networks (PINN). A novel residual-based adaptive PINN is developed and compared…

Numerical Analysis · Mathematics 2022-06-01 John M. Hanna , Jose V. Aguado , Sebastien Comas-Cardona , Ramzi Askri , Domenico Borzacchiello

Physics-informed neural networks (PINNs) have garnered significant interest for their potential in solving partial differential equations (PDEs) that govern a wide range of physical phenomena. By incorporating physical laws into the…

Machine Learning · Computer Science 2026-04-24 Jian Cheng Wong , Isaac Yin Chung Lai , Pao-Hsiung Chiu , Chin Chun Ooi , Abhishek Gupta , Yew-Soon Ong

In this study, the capabilities of the Physics-Informed Neural Network (PINN) method are investigated for three major tasks: modeling, simulation, and optimization in the context of the heat conduction problem. In the modeling phase, the…

Computational Physics · Physics 2025-10-31 Ehsan Ghaderi , Mohamad Ali Bijarchi , Siamak Kazemzadeh Hannani , Ali Nouri Boroujerdi

While the popularity of physics-informed neural networks (PINNs) is steadily rising, to this date PINNs have not been successful in simulating dynamical systems whose solution exhibits multi-scale, chaotic or turbulent behavior. In this…

Machine Learning · Computer Science 2022-03-16 Sifan Wang , Shyam Sankaran , Paris Perdikaris

Physics-Informed Neural Networks (PINN) are neural networks (NNs) that encode model equations, like Partial Differential Equations (PDE), as a component of the neural network itself. PINNs are nowadays used to solve PDEs, fractional…

Physics-informed neural networks (PINNs) have gained significant prominence as a powerful tool in the field of scientific computing and simulations. Their ability to seamlessly integrate physical principles into deep learning architectures…

Machine Learning · Computer Science 2024-04-05 Zakaria Elabid , Daniel Busby , Abdenour Hadid

Stiff differential equations are prevalent in various scientific domains, posing significant challenges due to the disparate time scales of their components. As computational power grows, physics-informed neural networks (PINNs) have led to…

Machine Learning · Computer Science 2025-01-30 Emilien Seiler , Wanzhou Lei , Pavlos Protopapas

In this study, we present and validate the predictive capability of the Physics-Informed Neural Networks (PINNs) methodology for solving a variety of engineering and biological dynamical systems governed by ordinary differential equations…

Machine Learning · Computer Science 2025-11-19 Tyrus Whitman , Andrew Particka , Christopher Diers , Ian Griffin , Charuka Wickramasinghe , Pradeep Ranaweera

In the past, we have presented a systematic computational framework for analyzing self-similar and traveling wave dynamics in nonlinear partial differential equations (PDEs) by dynamically factoring out continuous symmetries such as…

A physics informed neural network (PINN) incorporates the physics of a system by satisfying its boundary value problem through a neural network's loss function. The PINN approach has shown great success in approximating the map between the…

Numerical Analysis · Mathematics 2022-03-17 Revanth Mattey , Susanta Ghosh

Partial differential equations (PDEs) play a fundamental role in modeling and simulating problems across a wide range of disciplines. Recent advances in deep learning have shown the great potential of physics-informed neural networks…

Machine Learning · Computer Science 2022-01-31 Pu Ren , Chengping Rao , Yang Liu , Jianxun Wang , Hao Sun

Recently, physics informed neural networks (PINNs) have been explored extensively for solving various forward and inverse problems and facilitating querying applications in fluid mechanics applications. However, work on PINNs for unsteady…

Fluid Dynamics · Physics 2024-02-28 Rahul Sundar , Dipanjan Majumdar , Didier Lucor , Sunetra Sarkar

Physics-informed deep learning has drawn tremendous interest in recent years to solve computational physics problems, whose basic concept is to embed physical laws to constrain/inform neural networks, with the need of less data for training…

Fluid Dynamics · Physics 2020-11-24 Chengping Rao , Hao Sun , Yang Liu

Compared with conventional numerical approaches to solving partial differential equations (PDEs), physics-informed neural networks (PINN) have manifested the capability to save development effort and computational cost, especially in…

Machine Learning · Computer Science 2022-09-19 Shihong Zhang , Chi Zhang , Bosen Wang