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Engineered heart tissues (EHTs) present a potential solution to some of the current challenges in the treatment of heart disease; however, the development of mature, adult-like cardiac tissues remains elusive. Mechanical stimuli have been…

Tissues and Organs · Quantitative Biology 2023-06-02 Javiera Jilberto , Samuel J. DePalma , Jason Lo , Hiba Kobeissi , Lani Quach , Emma Lejeune , Brendon M. Baker , David Nordsletten

Artificial intelligence (AI) tools for radiology are commonly unmonitored once deployed. The lack of real-time case-by-case assessments of AI prediction confidence requires users to independently distinguish between trustworthy and…

Over the past few decades, researchers have developed several approaches such as the Reference Phantom Method (RPM) to estimate ultrasound attenuation coefficient (AC) and backscatter coefficient (BSC). AC and BSC can help to discriminate…

Medical Physics · Physics 2017-12-12 Kajoli Banerjee Krishnan , Nithin Nagaraj , Nitin Singhal , Shalini Thapar , Komal Yadav

Causal inference from electronic health records (EHR) is fundamentally limited by unmeasured confounding: critical clinical states such as frailty, goals of care, and mental status are documented in free-text notes but absent from…

Machine Learning · Computer Science 2026-04-22 Lei Liu , Jialin Chen , Kathy Macropol

We introduce a novel question-answering (QA) dataset using echocardiogram reports sourced from the Medical Information Mart for Intensive Care database. This dataset is specifically designed to enhance QA systems in cardiology, consisting…

Artificial Intelligence · Computer Science 2025-03-07 Lama Moukheiber , Mira Moukheiber , Dana Moukheiiber , Jae-Woo Ju , Hyung-Chul Lee

Extracellular matrix (ECM) remodeling is central to a wide variety of healthy and diseased tissue processes. Unfortunately, predicting ECM remodeling under various chemical and mechanical conditions has proven to be excessively challenging,…

Molecular Networks · Quantitative Biology 2026-05-26 Hasi Hays , William J. Richardson

After obtaining an accurate approximation for $ARL_0$, we first consider the optimal design of weight parameter for a multivariate EWMA chart that minimizes the stationary average delay detection time (SADDT). Comparisons with moving…

Statistics Theory · Mathematics 2022-06-24 Yanhong Wu , Wei Biao Wu

Cluster-randomized trials (CRTs) are widely used to evaluate group-level interventions and increasingly collect multiple outcomes capturing complementary dimensions of benefit and risk. Investigators often seek a single global summary of…

Methodology · Statistics 2026-01-22 Xinyuan Chen , Fan Li

In this article, we present a resource-efficient approach for electrocardiogram (ECG) based heartbeat classification using multi-feature fusion and bidirectional long short-term memory (Bi-LSTM). The dataset comprises five original classes…

Machine Learning · Computer Science 2024-12-16 Reza Nikandish , Jiayu He , Benyamin Haghi

Patient mobility monitoring in intensive care is critical for ensuring timely interventions and improving clinical outcomes. While accelerometry-based sensor data are widely adopted in training artificial intelligence models to estimate…

Background. Studies have shown that the conventional left ventricular mechanical dyssynchrony (LVMD) parameters have their own statistical limitations. The purpose of this study is to extract new LVMD parameters from the phase analysis of…

Medical Physics · Physics 2023-12-22 Zhuo He , Xinwei Zhang , Chen Zhao , Zhiyong Qian , Yao Wang , Xiaofeng Hou , Jiangang Zou , Weihua Zhou

Wearable sensing devices, such as Electrocardiogram (ECG) heart-rate monitors, will play a crucial role in the future of digital health. This continuous monitoring leads to massive unlabeled data, incentivizing the development of…

Machine Learning · Computer Science 2025-03-03 Adtian Atienza , Gouthamaan Manimaran , Jakob E. Bardram , Sadasivan Puthusserypady

Understanding the interaction between the valves and walls of the heart is important in assessing and subsequently treating heart dysfunction. With advancements in cardiac imaging, nonlinear mechanics and computational techniques, it is now…

Medical Physics · Physics 2017-04-07 Hao Gao , Liuyang Feng , Nan Qi , Colin Berry , Boyce Griffith , Xiaoyu Luo

Automated classification of electrocardiogram (ECG) signals is a useful tool for diagnosing and monitoring cardiovascular diseases. This study compares three traditional machine learning algorithms (Decision Tree Classifier, Random Forest…

Machine Learning · Computer Science 2026-04-20 Saloni Garg , Ukant Jadia , Amit Sagtani , Kamal Kant Hiran

Objective: Electronic health records (EHR) are widely available to complement administrative data-based disease surveillance and healthcare performance evaluation. Defining conditions from EHR is labour-intensive and requires extensive…

Computation and Language · Computer Science 2025-04-09 Jie Pan , Seungwon Lee , Cheligeer Cheligeer , Elliot A. Martin , Kiarash Riazi , Hude Quan , Na Li

Patients resuscitated from cardiac arrest (CA) face a high risk of neurological disability and death, however pragmatic methods are lacking for accurate and reliable prognostication. The aim of this study was to build computational models…

We assessed the benefit of combining stress cardiac CT perfusion (CCTP) myocardial blood flow (MBF) with coronary CT angiography (CCTA) using our innovative CCTP software. By combining CCTA and CCTP, one can uniquely identify a flow…

In longitudinal studies, repeated measures are collected over time and hence they tend to be serially correlated. In this paper we consider an extension of skew-normal/independent linear mixed models introduced by Lachos et al. (2010),…

Methodology · Statistics 2021-01-19 Fernanda L. Schumacher , Victor H. Lachos , Larissa A. Matos

Deep learning has achieved strong performance for electrocardiogram (ECG) classification within individual datasets, yet dependable generalization across heterogeneous acquisition settings remains a major obstacle to clinical deployment and…

Machine Learning · Computer Science 2025-12-30 Hai Duong Nguyen , Xuan-The Tran

Diagnostic test accuracy studies typically report the number of true positives, false positives, true negatives and false negatives. There usually exists a negative association between the number of true positives and true negatives,…

Methodology · Statistics 2015-11-06 Aristidis K. Nikoloulopoulos