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We propose a novel mechanism leading to spatiotemporal oscillations in extended systems that does not rely on local bulk instabilities. Instead, oscillations arise from the interaction of two subsystems of different spatial dimensionality.…

Other Condensed Matter · Physics 2007-05-23 A. Gomez-Marin , J. Garcia-Ojalvo , J. M. Sancho

Obstructions influence the growth and expansion of bodies in a wide range of settings -- but isolating and understanding their impact can be difficult in complex environments. Here, we study obstructed growth/expansion in a model system…

Soft Condensed Matter · Physics 2024-01-24 Abigail Plummer , Caroline Adkins , Jean-François Louf , Andrej Košmrlj , Sujit S. Datta

The shapes of epithelial tissues result from a complex interplay of contractile forces in the cytoskeleta of the cells in the tissue, and adhesion forces between them. A host of discrete, cell-based models describe these forces by assigning…

Soft Condensed Matter · Physics 2019-02-27 Pierra A. Haas , Raymond E. Goldstein

Bifurcation of an elastic structure crucially depends on the curvature of the constraints against which the ends of the structure are prescribed to move, an effect which deserves more attention than it has received so far. In fact, we show…

Mathematical Physics · Physics 2015-06-03 D. Bigoni , D. Misseroni , G. Noselli , D. Zaccaria

We study a model of contraction-based cell motility inside a microchannel to investigate the regulation of cell polarization and motion by the mechanical resistance of the environment. A positive feedback between the asymmetry of the…

Biological Physics · Physics 2024-02-28 Tapas Singha , Pierre Sens

Motivated by recent experiments showing the buckling of microtubules in cells, we study theoretically the mechanical response of, and force propagation along elastic filaments embedded in a non-linear elastic medium. We find that, although…

Soft Condensed Matter · Physics 2009-11-13 Moumita Das , Alex J. Levine , F. C. MacKintosh

Cell division and death can be regulated by the mechanical forces within a tissue. We study the consequences for the stability and roughness of a propagating interface, by analysing a model of mechanically-regulated tissue growth in the…

Biological Physics · Physics 2018-12-12 John J. Williamson , Guillaume Salbreux

We follow up on a companion work that considered growth rates of populations growing at different sites, with different randomly varying growth rates at each site, in the limit as migration between sites goes to 0. We extend this work here…

Populations and Evolution · Quantitative Biology 2018-09-12 David Steinsaltz , Shripad Tuljapurkar

In early years of life, the cranium rapidly changes in size and shape to accommodate brain growth, primarily driven by mechanical stress from brain expansion. Developmental disorders such as premature fusion of sutures in craniosynostosis,…

Tissues and Organs · Quantitative Biology 2025-10-30 Mahtab Vafaeefar , Conall Quinn , Ted J. Vaughan

A curious feature of organ and organoid morphogenesis is that in certain cases, spatial oscillations in the thickness of the growing "film" are out-of-phase with the deformation of the slower-growing "substrate," while in other cases, the…

Biological Physics · Physics 2018-12-26 T. A. Engstrom , Teng Zhang , A. K. Lawton , A. L. Joyner , J. M. Schwarz

We combine experiments with simulations to investigate the fluid-structure interaction of a flexible helical rod rotating in a viscous fluid, under low Reynolds number conditions. Our analysis takes into account the coupling between the…

Soft Condensed Matter · Physics 2015-10-28 M. K. Jawed , N. K. Khouri , F. Da , E. Grinspun , P. M. Reis

Initial residual stress is omnipresent in biological tissues and soft matter, and can affect growth-induced pattern selection significantly. Here we demonstrate this effect experimentally by letting soft tubes grow in the presence or…

Soft Condensed Matter · Physics 2020-09-11 Yangkun Du , Chaofeng Lü , Congshan Liu , Zilong Han , Jian Li , Weiqi Chen , Shaoxing Qua , Michel Destrade

Spontaneous growth of long-wavelength deformations is a defining feature of active fluids with orientational order. We investigate the effect of biaxial rectangular confinement on the instability of initially shear-aligned 3D isotropic…

Soft Condensed Matter · Physics 2021-01-04 Pooja Chandrakar , Minu Varghese , S. Ali Aghvami , Aparna Baskaran , Zvonimir Dogic , Guillaume Duclos

As we enter the age of designer matter - where objects can morph and change shape on command - what tools do we need to create shape-shifting structures? At the heart of an elastic deformation is the combination of dilation and distortion,…

Soft Condensed Matter · Physics 2018-09-14 Douglas P. Holmes

We scrutinize the temporally-resolved speed of active cargo transport in living cells, and show intermittent bursting motions. These nonlinear fluctuations follow a scaling law over several decades of time and space, the statistical…

Subcellular Processes · Quantitative Biology 2015-06-16 Bo Wang , James Kuo , Steve Granick

Biological cells can actively tune their intracellular architecture according to their overall shape. Here we explore the rheological implication of such coupling in a minimal model of a dense cellular material where each cell exerts an…

Soft Condensed Matter · Physics 2022-04-13 Shao-Zhen Lin , Matthias Merkel , Jean-François Rupprecht

We report the phenomenon of frequency clustering in a network of Hodgkin-Huxley neurons with spike timing-dependent plasticity. The clustering leads to a splitting of a neural population into a few groups synchronized at different…

Adaptation and Self-Organizing Systems · Physics 2019-12-20 Vera Röhr , Rico Berner , Ewandson L. Lameu , Oleksandr V. Popovych , Serhiy Yanchuk

Guided by experiments contrasting electrically accelerated recovery with natural healing, this study formulates a model to investigate the importance of electroactive differential growth and morphological changes in tissue repair. It…

Soft Condensed Matter · Physics 2025-04-30 Yafei Wang , Zhanfeng Li , Xingmei Chen , Yun Tan , Fucheng Wang , Yangkun Du , Yunce Zhang , Yipin Su , Fan Xu , Changguo Wang , Weiqiu Chen , Ji Liu

Underpinning the past decades of work on the design, initialization, and optimization of neural networks is a seemingly innocuous assumption: that the network is trained on a \textit{stationary} data distribution. In settings where this…

Machine Learning · Computer Science 2024-03-01 Clare Lyle , Zeyu Zheng , Khimya Khetarpal , Hado van Hasselt , Razvan Pascanu , James Martens , Will Dabney

Crack advance from short or long pre-cracks is predicted by the progressive failure of a cohesive zone in a strain gradient, elasto-plastic solid. The presence of strain gradients leads to the existence of an elastic zone at the tip of a…