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Infectious disease dynamics operate across multiple biological scales, with within-host viral dynamics being a key driver of between-host transmission. However, while models that explicitly link these scales exist, none have been developed…

Applications · Statistics 2026-04-23 Dylan J. Morris , Lauren Kennedy , Andrew J. Black

Recent developments in Machine Learning approaches for modelling physical systems have begun to mirror the past development of numerical methods in the computational sciences. In this survey, we begin by providing an example of this with…

Machine Learning · Computer Science 2023-04-04 Artur P. Toshev , Ludger Paehler , Andrea Panizza , Nikolaus A. Adams

Capturing the structured mixing within a population is key to the reliable projection of infectious disease dynamics and hence informed control. Both heterogeneity in the number of contacts and age-structured mixing have been repeatedly…

Social and Information Networks · Computer Science 2026-03-17 Luke Murray Kearney , Emma L Davis , Matt J Keeling

We consider a continuous-time Markov chain model of SIR disease dynamics with two levels of mixing. For this so-called stochastic households model, we provide two methods for inferring the model parameters---governing within-household…

Populations and Evolution · Quantitative Biology 2018-02-07 James N. Walker , Joshua V. Ross , Andrew J. Black

We consider the spread of infectious disease through contact networks of Configuration Model type. We assume that the disease spreads through contacts and infected individuals recover into an immune state. We discuss a number of existing…

Populations and Evolution · Quantitative Biology 2014-03-11 Joel C Miller , Istvan Z Kiss

The transmission dynamics of an epidemic are rarely homogeneous. Super-spreading events and super-spreading individuals are two types of heterogeneous transmissibility. Inference of super-spreading is commonly carried out on secondary case…

Quantitative Methods · Quantitative Biology 2025-01-23 Hannah Craddock , Simon EF Spencer , Xavier Didelot

Infected individuals in some epidemics can remain asymptomatic while still carrying and transmitting the infection. These individuals contribute to the spread of the epidemic and pose a significant challenge to public health policies.…

Social and Information Networks · Computer Science 2026-02-03 Conrado Catarcione Pinto , Amanda Camacho Novaes de Oliveira , Rodrigo Sapienza Luna , Daniel Ratton Figueiredo

In this research, we aim to compare the performance of different classical machine learning models and neural networks in identifying the frequency of occurrence of each digit in a given number. It has various applications in machine…

Machine Learning · Computer Science 2024-02-01 Padmaksh Khandelwal

The robustness of a network is depending on the type of attack we are considering. In this paper we focus on the spread of viruses on networks. It is common practice to use the epidemic threshold as a measure for robustness. Because the…

Discrete Mathematics · Computer Science 2008-12-11 Robert Kooij , Phillip Schumm , Caterina Scoglio

This paper deals with the problem of estimating variables in nonlinear models for the spread of disease and its application to the COVID-19 epidemic. First unconstrained methods are revisited and they are shown to correspond to the…

Optimization and Control · Mathematics 2020-08-20 Mauricio C. de Oliveira

We discuss two sampling schemes for selecting random subnets from a network: Random sampling and connectivity dependent sampling, and investigate how the degree distribution of a node in the network is affected by the two types of sampling.…

Statistical Mechanics · Physics 2009-11-11 Michael P. H. Stumpf , Carsten Wiuf

We study the problem of identifying infection sources in a network based on the network topology, and a subset of infection timestamps. In the case of a single infection source in a tree network, we derive the maximum likelihood estimator…

Social and Information Networks · Computer Science 2019-03-06 Wenchang Tang , Feng Ji , Wee Peng Tay

Researchers, policy makers, and engineers need to make sense of data from spreading processes as diverse as rumor spreading in social networks, viral infections, and water contamination. Classical questions include predicting infection…

Data Structures and Algorithms · Computer Science 2026-01-08 Ben Bals , Michelle Döring , Nicolas Klodt , George Skretas

Locating the source of an epidemic, or patient zero (P0), can provide critical insights into the infection's transmission course and allow efficient resource allocation. Existing methods use graph-theoretic centrality measures and expensive…

Social and Information Networks · Computer Science 2020-06-30 Chintan Shah , Nima Dehmamy , Nicola Perra , Matteo Chinazzi , Albert-László Barabási , Alessandro Vespignani , Rose Yu

Bootstrap percolation is a process that is used to model the spread of an infection on a given graph. In the model considered here each vertex is equipped with an individual threshold. As soon as the number of infected neighbors exceeds…

Probability · Mathematics 2022-10-25 Nils Detering , Thilo Meyer-Brandis , Konstantinos Panagiotou

We investigate the information-theoretical limits of inference tasks in epidemic spreading on graphs in the thermodynamic limit. The typical inference tasks consist in computing observables of the posterior distribution of the epidemic…

Physics and Society · Physics 2023-12-25 Alfredo Braunstein , Louise Budzynski , Matteo Mariani

Models of epidemics over networks have become popular, as they describe the impact of individual behavior on infection spread. However, they come with high computational complexity, which constitutes a problem in case large-scale scenarios…

Systems and Control · Electrical Eng. & Systems 2026-02-10 Davide Zorzenon , Fabio Molinari , Joerg Raisch

Epidemic dynamics in a stochastic network of interacting epidemic centers is considered. The epidemic and migration processes are modelled by Markov's chains. Explicit formulas for probability distribution of the migration process are…

Populations and Evolution · Quantitative Biology 2015-05-05 Igor Sazonov , Mark Kelbert

The emergence and spread of deadly pandemics has repeatedly occurred throughout history, causing widespread infections and loss of life. The rapid spread of pandemics have made governments across the world adopt a range of actions,…

Populations and Evolution · Quantitative Biology 2024-01-15 Marianna Karapitta , Andreas Kasis , Charithea Stylianides , Kleanthis Malialis , Panayiotis Kolios

Two crucial elements facilitate the understanding and control of communicable disease spread within a social setting. These components are, the underlying contact structure among individuals that determines the pattern of disease…

Populations and Evolution · Quantitative Biology 2013-05-29 Pierre-Andre Noel , Bahman Davoudi , Louis J. Dube , Robert C. Brunham , Babak Pourbohloul