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Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Instruction finetuning is a popular paradigm to align large language models (LLM) with human intent. Despite its popularity, this idea is less explored in improving LLMs to align existing foundation models with scientific disciplines,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Sameera Horawalavithana , Sai Munikoti , Ian Stewart , Henry Kvinge , Karl Pazdernik

Efficient finetuning of pretrained language transformers is becoming increasingly prevalent for solving natural language processing tasks. While effective, it can still require a large number of tunable parameters. This can be a drawback…

Computation and Language · Computer Science 2023-05-31 Umang Gupta , Aram Galstyan , Greg Ver Steeg

As the performance of larger, newer Large Language Models continues to improve for strategic Theory of Mind (ToM) tasks, the demand for these state-of-the-art models increases commensurately. However, their deployment is costly both in…

Computation and Language · Computer Science 2024-11-01 Nunzio Lore , Sepehr Ilami , Babak Heydari

Large language models (LLMs), despite their breakthroughs on many challenging benchmark tasks, lean to generate verbose responses and lack the controllability of output complexity, which is usually preferred by human users in practice. In…

Computation and Language · Computer Science 2024-06-25 Dang Nguyen , Jiuhai Chen , Tianyi Zhou

Model merging provides a scalable alternative to multi-task training by combining specialized finetuned models through parameter arithmetic, enabling efficient deployment without the need for joint training or access to all task data. While…

Machine Learning · Computer Science 2025-10-21 Yifei He , Siqi Zeng , Yuzheng Hu , Rui Yang , Tong Zhang , Han Zhao

Fine-tuning pre-trained Neural Machine Translation (NMT) models is the dominant approach for adapting to new languages and domains. However, fine-tuning requires adapting and maintaining a separate model for each target task. We propose a…

Computation and Language · Computer Science 2019-09-19 Ankur Bapna , Naveen Arivazhagan , Orhan Firat

Existing domain-specific Large Language Models (LLMs) are typically developed by fine-tuning general-purposed LLMs with large-scale domain-specific corpora. However, training on large-scale corpora often fails to effectively organize domain…

Computation and Language · Computer Science 2025-02-11 Zhiqiang Liu , Chengtao Gan , Junjie Wang , Yichi Zhang , Zhongpu Bo , Mengshu Sun , Huajun Chen , Wen Zhang

Foundation models have emerged as a powerful tool for many AI problems. Despite the tremendous success of foundation models, effective adaptation to new tasks, particularly those with limited labels, remains an open question and lacks…

Machine Learning · Computer Science 2024-02-26 Zhuoyan Xu , Zhenmei Shi , Junyi Wei , Fangzhou Mu , Yin Li , Yingyu Liang

Large Language Models (LLMs) have demonstrated significant potential in transforming clinical applications. In this study, we investigate the efficacy of four techniques in adapting LLMs for clinical use-cases: continuous pretraining,…

Multi-domain fine-tuning of large language models requires improving performance on target domains while preserving performance on constrained domains, such as general knowledge, instruction following, or safety evaluations. Existing data…

Machine Learning · Computer Science 2026-05-12 Eleonora Gualdoni , Sonia Laguna , Louis Bethune , Joao Monteiro , Pierre Ablin , Marco Cuturi

Continual pre-training has been urgent for adapting a pre-trained model to a multitude of domains and tasks in the fast-evolving world. In practice, a continually pre-trained model is expected to demonstrate not only greater capacity when…

Computation and Language · Computer Science 2023-10-23 Gangwei Jiang , Caigao Jiang , Siqiao Xue , James Y. Zhang , Jun Zhou , Defu Lian , Ying Wei

With the surge of ChatGPT,the use of large models has significantly increased,rapidly rising to prominence across the industry and sweeping across the internet. This article is a comprehensive review of fine-tuning methods for large models.…

Machine Learning · Computer Science 2024-04-16 Benjue Weng

Prediction tasks in digital pathology are challenging due to the massive size of whole-slide images (WSIs) and the weak nature of training signals. Advances in computing, data availability, and self-supervised learning (SSL) have paved the…

Image and Video Processing · Electrical Eng. & Systems 2026-02-02 Vishwesh Ramanathan , Tony Xu , Pushpak Pati , Faruk Ahmed , Maged Goubran , Anne L. Martel

This paper introduces an efficient strategy to transform Large Language Models (LLMs) into Multi-Modal Large Language Models (MLLMs). By conceptualizing this transformation as a domain adaptation process, i.e., transitioning from text…

Computation and Language · Computer Science 2023-12-19 Bingchen Zhao , Haoqin Tu , Chen Wei , Jieru Mei , Cihang Xie

Large Language Models (LLMs), trained on extensive web-scale corpora, have demonstrated remarkable abilities across diverse tasks, especially as they are scaled up. Nevertheless, even state-of-the-art models struggle in certain cases,…

Computation and Language · Computer Science 2025-01-16 Irina Bigoulaeva , Harish Tayyar Madabushi , Iryna Gurevych

Large pre-trained models have been vital in recent advancements in domains like language and vision, making model training for individual downstream tasks more efficient and provide superior performance. However, tackling time-series…

Machine Learning · Computer Science 2024-12-06 Harshavardhan Kamarthi , B. Aditya Prakash

With the capabilities of understanding and executing natural language instructions, Large language models (LLMs) can potentially act as a powerful tool for textual data augmentation. However, the quality of augmented data depends heavily on…

Computation and Language · Computer Science 2024-04-30 Yichuan Li , Kaize Ding , Jianling Wang , Kyumin Lee

When adapting large language models (LLMs) to a specific downstream task, two primary approaches are commonly employed: (1) prompt engineering, often with in-context few-shot learning, leveraging the model's inherent generalization…

Machine Learning · Computer Science 2025-12-24 Jorg Bornschein , Clare Lyle , Yazhe Li , Amal Rannen-Triki , Xu Owen He , Razvan Pascanu

Automatic performance tuning (auto-tuning) is essential for optimizing high-performance applications, where vast and irregular search spaces make manual exploration infeasible. While auto-tuners traditionally rely on classical approaches…

Machine Learning · Computer Science 2026-04-01 Floris-Jan Willemsen , Niki van Stein , Ben van Werkhoven
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