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Recently, super-resolution ultrasound imaging with ultrasound localization microscopy (ULM) has received much attention. However, ULM relies on low concentrations of microbubbles in the blood vessels, ultimately resulting in long…

Super-resolution ultrasound (SR-US) is a powerful imaging technique for capturing microvasculature and blood flow at high spatial resolution. However, accurate microbubble (MB) localization remains a key challenge, as errors in localization…

Image and Video Processing · Electrical Eng. & Systems 2025-01-06 Sepideh K. Gharamaleki , Brandon Helfield , Hassan Rivaz

Super-resolution ultrasound imaging (SRUS) is an active area of research as it brings up to a ten-fold improvement in the resolution of microvascular structures. The limitations to the clinical adoption of SRUS include long acquisition…

Image and Video Processing · Electrical Eng. & Systems 2024-08-05 Arthur David Redfern , Katherine G. Brown

Generation of super-resolution (SR) ultrasound (US) images, created from the successive local-ization of individual microbubbles in the circulation, has enabled the visualization of microvascular structure and flow at a level of detail that…

Image and Video Processing · Electrical Eng. & Systems 2024-06-19 Scott Schoen , Zhigen Zhao , Ashley Alva , Chengwu Huang , Shigao Chen , Costas Arvanitis

Ultrasound localization microscopy has enabled super-resolution vascular imaging through precise localization of individual ultrasound contrast agents (microbubbles) across numerous imaging frames. However, analysis of high-density regions…

Signal Processing · Electrical Eng. & Systems 2018-12-14 Ruud J. G. van Sloun , Oren Solomon , Matthew Bruce , Zin Z. Khaing , Hessel Wijkstra , Yonina C. Eldar , Massimo Mischi

Ultrasound Localization Microscopy can resolve the microvascular bed down to a few micrometers. To achieve such performance microbubble contrast agents must perfuse the entire microvascular network. Microbubbles are then located…

Computer Vision and Pattern Recognition · Computer Science 2023-10-13 Léo Milecki , Jonathan Porée , Hatim Belgharbi , Chloé Bourquin , Rafat Damseh , Patrick Delafontaine-Martel , Frédéric Lesage , Maxime Gasse , Jean Provost

To overcome the half a wavelength resolution limitations of ultrasound imaging, microbubbles (MBs) have been utilized widely in the field. Conventional MB localization methods are limited whether by exhaustive parameter tuning or…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Sepideh K. Gharamaleki , Brandon Helfield , Hassan Rivaz

Ultrasound localization microscopy (ULM) refers to a promising medical imaging modality that systematically leverages the advantages of contrast-enhanced ultrasound (CEUS) to surpass the diffraction barrier and delineate the microvascular…

Image and Video Processing · Electrical Eng. & Systems 2022-09-22 Md Ashikuzzaman , Brandon Helfield , Hassan Rivaz

Resolving arterial flows is essential for understanding cardiovascular pathologies, improving diagnosis, and monitoring patient condition. Ultrasound contrast imaging uses microbubbles to enhance the scattering of the blood pool, allowing…

Ultrasound Localization Microscopy (ULM) is an emerging technique that employs the localization of echogenic microbubbles (MBs) to finely sample and image the microcirculation beyond the diffraction limit of ultrasound imaging. Conventional…

Image and Video Processing · Electrical Eng. & Systems 2022-09-27 Sepideh K. Gharamaleki , Brandon Helfield , Hassan Rivaz

The purpose of this study is to enable in-vivo three-dimensional (3-D) ultrasound localization microscopy (ULM) of posterior ocular microvasculature using a 256-channel system and a 1024-element matrix array, and to overcome limitations of…

Ultrasound localization microscopy offers new radiation-free diagnostic tools for vascular imaging deep within the tissue. Sequential localization of echoes returned from inert microbubbles with low-concentration within the bloodstream…

Medical Physics · Physics 2018-04-11 Oren Solomon , Ruud J. G. van Sloun , Hessel Wijkstra , Massimo Mischi , Yonina C. Eldar

Contrast-Enhanced Ultra-Sound (CEUS) has become a viable method for non-invasive, dynamic visualization in medical diagnostics, yet Ultrasound Localization Microscopy (ULM) has enabled a revolutionary breakthrough by offering ten times…

Computer Vision and Pattern Recognition · Computer Science 2023-07-19 Christopher Hahne , Raphael Sznitman

Spherical deconvolution (SD) methods are widely used to estimate the intra-voxel white-matter fiber orientations from diffusion MRI data. However, while some of these methods assume a zero-mean Gaussian distribution for the underlying…

Super-resolution ultrasound via microbubble (MB) localisation and tracking, also known as ultrasound localisation microscopy (ULM), can resolve microvasculature beyond the acoustic diffraction limit. However, significant challenges remain…

Ultrasound Localization Microscopy (ULM) can map microvessels at a resolution of a few micrometers (\mu m). Transcranial ULM remains challenging in presence of aberrations caused by the skull, which lead to localization errors. Herein, we…

Image and Video Processing · Electrical Eng. & Systems 2023-09-20 Paul Xing , Jonathan Porée , Brice Rauby , Antoine Malescot , Éric Martineau , Vincent Perrot , Ravi L. Rungta , Jean Provost

Ultrasound super-localization microscopy techniques presented in the last few years enable non-invasive imaging of vascular structures at the capillary level by tracking the flow of ultrasound contrast agents (gas microbubbles). However,…

Tissues and Organs · Quantitative Biology 2016-08-10 Avinoam Bar-Zion , Charles Tremblay-Darveau , Oren Solomon , Dan Adam , Yonina C. Eldar

Removing speckle noise from medical ultrasound images while preserving image features without introducing artifact and distortion is a major challenge in ultrasound image restoration. In this paper, we propose a multiframe-based adaptive…

Image and Video Processing · Electrical Eng. & Systems 2021-09-30 Jayanta Dey , Md. Kamrul Hasan

Ultrafast ultrasound localization microscopy (ULM), which has shown promising results in microvascular imaging, overcomes the typical trade-off between resolution and penetration depth. Combining ultrasound contrast agents and high frame…

Signal Processing · Electrical Eng. & Systems 2024-07-02 A. N. Madhavanunni , Niya Mariam Benoy , Mahesh Raveendranatha Panicker , Himanshu Shekhar

Poor resolution of ultrasound images due to convolution of the tissue reflectivity function (TRF) with the system point spread function (PSF) is a major issue in medical ultrasound imaging. In this paper, we propose a correlation…

Signal Processing · Electrical Eng. & Systems 2018-06-08 Jayanta Dey , Md. Kamrul Hasan
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