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Super-resolution ultrasound imaging with ultrasound localization microscopy (ULM) offers a high-resolution view of microvascular structures. Yet, ULM image quality heavily relies on precise microbubble (MB) detection. Despite the crucial…

Artificial Intelligence · Computer Science 2026-01-15 Sepideh K. Gharamaleki , Brandon Helfield , Hassan Rivaz

We proposed a deconvolution optical-resolution photoacoustic microscope for high -resolution imaging of brain. The focal spot of the photoacoustic microscopy is measured to obtain the lateral PSF (point spread function) of the system.…

Medical Physics · Physics 2020-11-05 Xianlin Song , Lingfang Song , Anqing Chen , Jianshuang Wei

Non-invasive detection of microvascular alterations in deep tissues in vivo provides critical information for clinical diagnosis and evaluation of a broad-spectrum of pathologies. Recently, the emergence of super-resolution ultrasound…

Ultrasound Localization Microscopy (ULM) has recently enabled the mapping of the cerebral vasculature in vivo with a resolution ten times smaller than the wavelength used, down to ten microns. However, with frame rates up to 20.000 frames…

Medical Physics · Physics 2023-10-23 Erwan Hardy , Jonathan Poree , Hatim Belgharbi , Chloe Bourquin , Frederic Lesage , Jean Provost

Super-Resolution Ultrasound (SRUS) imaging through localising and tracking microbubbles, also known as Ultrasound Localisation Microscopy (ULM), has demonstrated significant potential for reconstructing microvasculature and flows with…

Image and Video Processing · Electrical Eng. & Systems 2025-03-26 Jipeng Yan , Qingyuan Tan , Shusei Kawara , Jingwen Zhu , Bingxue Wang , Matthieu Toulemonde , Honghai Liu , Ying Tan , Meng-Xing Tang

Fluorescence microscopy is widely used for the study of biological specimens. Deconvolution can significantly improve the resolution and contrast of images produced using fluorescence microscopy; in particular, Bayesian-based methods have…

Methodology · Statistics 2015-02-04 Alexander Wong , Xiao Yu Wang , Maud Gorbet

Transient brain-wide neuroimaging on a microscopic scale is pivotal for brain research, yet current modalities face challenges in meeting such spatiotemporal requirements. Functional ultrasound (fUS) enables transient neurovascular imaging…

Medical Physics · Physics 2025-12-09 Yang Cai , Shaoyuan Yan , Long Xu , Yanfeng Zhu , Bo Li , Kailiang Xu

In this paper, we introduce a novel unsupervised network to denoise microscopy videos featured by image sequences captured by a fixed location microscopy camera. Specifically, we propose a DeepTemporal Interpolation method, leveraging a…

Image and Video Processing · Electrical Eng. & Systems 2024-04-19 Mary Aiyetigbo , Alexander Korte , Ethan Anderson , Reda Chalhoub , Peter Kalivas , Feng Luo , Nianyi Li

Functional ultrasound (fUS) indirectly measures brain activity by recording changes in cerebral blood volume and flow in response to neural activation. Conventional approaches model such functional neuroimaging data as the convolution…

Signal Processing · Electrical Eng. & Systems 2022-05-26 Aybuke Erol , Chagajeg Soloukey , Bastian Generowicz , Nikki Van Dorp , Sebastiaan Koekkoek , Pieter Kruizinga , Borbala Hunyadi

Ultrasound Localization Microscopy (ULM) enables imaging of vascular structures in the micrometer range by accumulating contrast agent particle locations over time. Precise and efficient target localization accuracy remains an active…

Image and Video Processing · Electrical Eng. & Systems 2023-11-08 Christopher Hahne , Georges Chabouh , Olivier Couture , Raphael Sznitman

Wide-field fluorescence microscopy with compact optics often suffers from spatially varying blur due to field-dependent aberrations, vignetting, and sensor truncation, while finite sensor sampling imposes an inherent trade-off between field…

Image and Video Processing · Electrical Eng. & Systems 2026-02-03 Qianwan Yang , Zhixiong Chen , Jiaqi Zhang , Ruipeng Guo , Guorong Hu , Lei Tian

Ultrasound imaging serves as an effective and non-invasive diagnostic tool commonly employed in clinical examinations. However, the presence of speckle noise in ultrasound images invariably degrades image quality, impeding the performance…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 Zhenyu Bu , Kai-Ni Wang , Fuxing Zhao , Shengxiao Li , Guang-Quan Zhou

High resolution transcranial ultrasound imaging in humans has been a persistent challenge for ultrasound due to the imaging degradation effects from aberration and reverberation. These mechanisms depend strongly on skull morphology and they…

Medical Physics · Physics 2018-11-28 Danai E. Soulioti , David Espíndola , Paul A. Dayton , Gianmarco Pinton

Beamforming is an essential step in the ultrasound image formation pipeline and has recently attracted growing interest. An important goal of beamforming is to increase the image spatial resolution, or in other words to narrow down the…

Image and Video Processing · Electrical Eng. & Systems 2022-09-01 Sobhan Goudarzi , Adrian Basarab , Hassan Rivaz

Recent advances in deep learning have been pushing image denoising techniques to a new level. In self-supervised image denoising, blind-spot network (BSN) is one of the most common methods. However, most of the existing BSN algorithms use a…

Computer Vision and Pattern Recognition · Computer Science 2023-04-10 Dan Zhang , Fangfang Zhou , Yuwen Jiang , Zhengming Fu

Ultrasound localization microscopy (ULM) enables microvascular imaging at spatial resolutions beyond the acoustic diffraction limit, offering significant clinical potentials. However, ULM performance relies heavily on microbubble (MB)…

Ultrasound is widely used in medical diagnostics allowing for accessible and powerful imaging but suffers from resolution limitations due to diffraction and the finite aperture of the imaging system, which restricts diagnostic use. The…

Computer Vision and Pattern Recognition · Computer Science 2024-08-08 Felix Duelmer , Walter Simson , Mohammad Farid Azampour , Magdalena Wysocki , Angelos Karlas , Nassir Navab

Identifying and visualizing vasculature within organs and tumors has major implications in managing cardiovascular diseases and cancer. Contrast-enhanced ultrasound scans detect slow-flowing blood, facilitating non-invasive perfusion…

Medical Physics · Physics 2018-09-18 Avinoam Bar-Zion , Oren Solomon , Charles Tremblay-Darveau , Dan Adam , Yonina C. Eldar

A multiscale representation-based denoising method for spherical data contaminated with Poisson noise, the multiscale variance stabilizing transform on the sphere (MS-VSTS), has been previously proposed. This paper first extends this…

Instrumentation and Methods for Astrophysics · Physics 2015-06-05 Jérémy Schmitt , Jean-Luc Starck , Jean-Marc Casandjian , Jalal Fadili , Isabelle Grenier

Our work aims at using quantitative imaging tools to complement the limitation of noise encountered by high resolution fluorescence microscopy methods. Several cycles of fluorophore activation, imaging and deactivation produce a sequence of…

Quantitative Methods · Quantitative Biology 2012-02-03 Juliane Liepe , Federico Felizzi , Agata Pernus , Maria Hanulova