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Biological signaling is imagined as a combination of activation and transport. The former is triggered by local molecular interactions and the latter is the result of molecular diffusion. However, other fundamental physical principles of…
The effectiveness of biochemical antivirals are vulnerable to mutations, motivating physical approaches. Recent experiments with ultrasound reveal viral disruption at MHz frequencies, yet the mechanism remains unclear. We model viruses as…
Local changes in pH are known to significantly alter the state and activity of proteins and in particular enzymes. pH variations induced by pulses propagating along soft interfaces (e.g. the lipid bilayer) would therefore constitute an…
Fast detection and characterization of single nanoparticles such as viruses, airborne aerosols and colloidal particles are considered to be particularly important for medical applications, material science and atmospheric physics. In…
Label free tracking of small bio-particles such as proteins or viruses is of great utility in the study of biological processes, however such experiments are frequently hindered by weak signal strengths and a susceptibility to scattering…
We discuss three different aspects of the quantum dynamics of bio-molecular systems and more generally complex networks in the presence of strongly coupled environments. Firstly, we make a case for the systematic study of fundamental…
We demonstrate multimode optomechanical sensing of individual nanoparticles with radius of a hundred of nanometers. A semiconductor optomechanical disk resonator is optically driven and detected under ambient conditions, as nebulized…
We aim to automatize the identification of collective variables to simplify and speed up enhanced sampling simulations of conformational dynamics in biomolecules. We focus on anharmonic low-frequency vibrations that exhibit fluctuations on…
The detailed characterization of non-trivial coherence properties of composite quantum systems of increasing size is an indispensable prerequisite for scalable quantum computation, as well as for understanding of nonequilibrium many-body…
A single qubit driven by an appropriate sequence of control pulses can serve as a spectrometer of local noise affecting its energy splitting. We show that by driving and observing two spatially separated qubits, it is possible to…
We show that quasi localized low-frequency modes in the vibrational spectrum can be used to construct soft spots, or regions vulnerable to rearrangement, which serve as a universal tool for the identification of flow defects in solids. We…
We address the characterization of classical fractional random noise via quantum probes. In particular, we focus on estimation and discrimination problems involving the fractal dimension of the trajectories of a system subject to fractional…
We carry out a theoretical study of the vibrational and relaxation properties of naturally-occurring proteins with the purpose of characterizing both the folding and equilibrium thermodynamics. By means of a suitable model we provide a full…
We measure molecular vibrations with femtometer precision using time-resolved x-ray absorption spectroscopy. For a demonstration, a Raman process excites the A$_{1g}$ mode in gas-phase SF$_6$ molecules with an amplitude of $\approx50$ fm,…
Acoustic vibrations of nanoparticles made of materials with anisotropic elasticity and nanoparticles with non-spherical shapes are theoretically investigated using a homogeneous continuum model. Cubic, hexagonal and tetragonal symmetries of…
The phonon spectra of solids, described through the measurable vibrational density of states (VDOS), provide a wealth of information about the underlying atomic structure and bonding, and they determine fundamental macroscopic properties…
Experimental studies of the diffusion of biomolecules in the environment of biological cells are routinely confronted with multiple sources of stochasticity, whose identification renders the detailed data analysis of single molecule…
We show theoretically how a correlation of multiple measurements on a qubit undergoing pure dephasing can be expressed as environmental noise filtering. The measurement of such correlations can be used for environmental noise spectroscopy,…
Single particle tracking is essential in many branches of science and technology, from the measurement of biomolecular forces to the study of colloidal crystals. Standard current methods rely on algorithmic approaches: by fine-tuning…
Proteins are the active working horses in our body. These biomolecules perform all vital cellular functions from DNA replication and general biosynthesis to metabolic signaling and environmental sensing. While static 3D structures are now…