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Despite the potential of Large Language Models (LLMs) in medicine, they may generate responses lacking supporting evidence or based on hallucinated evidence. While Retrieval Augment Generation (RAG) is popular to address this issue, few…

Retrieval Augmented Generation (RAG) has emerged as a powerful application of Large Language Models (LLMs), revolutionizing information search and consumption. RAG systems combine traditional search capabilities with LLMs to generate…

Information Retrieval · Computer Science 2025-06-12 Harsh Maheshwari , Srikanth Tenneti , Alwarappan Nakkiran

Retrieval-Augmented Generation (RAG) has emerged as a prominent method for incorporating domain knowledge into Large Language Models (LLMs). While RAG enhances response relevance by incorporating retrieved domain knowledge in the context,…

Computation and Language · Computer Science 2025-03-28 Kushagra Bhushan , Yatin Nandwani , Dinesh Khandelwal , Sonam Gupta , Gaurav Pandey , Dinesh Raghu , Sachindra Joshi

Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Quantitative Methods · Quantitative Biology 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

Large language models (LLMs) inevitably exhibit hallucinations since the accuracy of generated texts cannot be secured solely by the parametric knowledge they encapsulate. Although retrieval-augmented generation (RAG) is a practicable…

Computation and Language · Computer Science 2024-10-08 Shi-Qi Yan , Jia-Chen Gu , Yun Zhu , Zhen-Hua Ling

Biomedical semantic question answering rooted in information retrieval can play a crucial role in keeping up to date with vast, rapidly evolving and ever-growing biomedical literature. A robust system can help researchers, healthcare…

Information Retrieval · Computer Science 2025-07-09 Shashank Verma , Fengyi Jiang , Xiangning Xue

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Retrieval augmented generation (RAG) systems provide a method for factually grounding the responses of a Large Language Model (LLM) by providing retrieved evidence, or context, as support. Guided by this context, RAG systems can reduce…

Information Retrieval · Computer Science 2025-09-05 Shakiba Amirshahi , Amin Bigdeli , Charles L. A. Clarke , Amira Ghenai

Recent advancements in Large language models (LLMs) have demonstrated remarkable capabilities across diverse domains. While they exhibit strong zero-shot performance on various tasks, LLMs' effectiveness in music-related applications…

Computation and Language · Computer Science 2025-12-09 Daeyong Kwon , SeungHeon Doh , Juhan Nam

Retrieval-Augmented Generation (RAG) has emerged as a powerful paradigm for enhancing the capabilities of large language models. However, existing RAG evaluation predominantly focuses on text retrieval and relies on opaque, end-to-end…

Information Retrieval · Computer Science 2025-05-19 Chuan Xu , Qiaosheng Chen , Yutong Feng , Gong Cheng

Multimodal Retrieval-Augmented Generation (MRAG) enhances large language models (LLMs) by integrating multimodal data (text, images, videos) into retrieval and generation processes, overcoming the limitations of text-only…

Information Retrieval · Computer Science 2025-04-15 Lang Mei , Siyu Mo , Zhihan Yang , Chong Chen

The BioModels database is one of the premier databases for computational models in systems biology. The database contains over 1000 curated models and an even larger number of non-curated models. All the models are stored in the…

Molecular Networks · Quantitative Biology 2026-02-02 Bhavyahshree Navaneetha Krishnan , Adel Heydarabadipour , Herbert Sauro

Large Language Models (LLMs) have shown remarkable capabilities across diverse tasks, yet they face inherent limitations such as constrained parametric knowledge and high retraining costs. Retrieval-Augmented Generation (RAG) augments the…

Information Retrieval · Computer Science 2025-08-26 Leqian Li , Dianxi Shi , Jialu Zhou , Xinyu Wei , Mingyue Yang , Songchang Jin , Shaowu Yang

The retrieval-augmented generation (RAG) approach is used to reduce the confabulation of large language models (LLMs) for question answering by retrieving and providing additional context coming from external knowledge sources (e.g., by…

Computation and Language · Computer Science 2024-10-30 Alexander Bondarenko , Adrian Viehweger

Retrieval-Augmented Generation (RAG) offers a cost-effective approach to injecting real-time knowledge into large language models (LLMs). Nevertheless, constructing and validating high-quality knowledge repositories require considerable…

Computation and Language · Computer Science 2024-05-28 Xun Liang , Simin Niu , Zhiyu li , Sensen Zhang , Shichao Song , Hanyu Wang , Jiawei Yang , Feiyu Xiong , Bo Tang , Chenyang Xi

Language models (LMs) are known to suffer from hallucinations and misinformation. Retrieval augmented generation (RAG) that retrieves verifiable information from an external knowledge corpus to complement the parametric knowledge in LMs…

Computation and Language · Computer Science 2024-10-14 Zhuohang Li , Jiaxin Zhang , Chao Yan , Kamalika Das , Sricharan Kumar , Murat Kantarcioglu , Bradley A. Malin

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating external knowledge sources, enabling more accurate and contextually relevant responses tailored to user queries. These systems, however, remain…

Computation and Language · Computer Science 2025-05-26 Huichi Zhou , Kin-Hei Lee , Zhonghao Zhan , Yue Chen , Zhenhao Li , Zhaoyang Wang , Hamed Haddadi , Emine Yilmaz

Retrieval-Augmented Generation (RAG) enhances Large Language Model (LLM) output by providing prior knowledge as context to input. This is beneficial for knowledge-intensive and expert reliant tasks, including legal question-answering, which…

The deployment of large language models (LLMs) like ChatGPT and Gemini has shown their powerful natural language generation capabilities. However, these models can inadvertently learn and retain sensitive information and harmful content…

Cryptography and Security · Computer Science 2025-10-14 Shang Wang , Tianqing Zhu , Dayong Ye , Wanlei Zhou

Iterative retrieval refers to the process in which the model continuously queries the retriever during generation to enhance the relevance of the retrieved knowledge, thereby improving the performance of Retrieval-Augmented Generation…

Computation and Language · Computer Science 2024-12-02 Tian Yu , Shaolei Zhang , Yang Feng