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Single-stranded libraries generated from ancient DNA extracts have specific sequencing requirements. The short library molecules typically associated with ancient DNA templates are expected to behave differently during the annealing to the…

Other Quantitative Biology · Quantitative Biology 2017-11-30 Johanna L. A. Paijmans , Sina Baleka , Kirstin Henneberger , Ulrike H. Taron , Alexandra Trinks , Michael V. Westbury , Axel Barlow

To retrieve and compare scientific data of simulations and experiments in materials science, data needs to be easily accessible and machine readable to qualify and quantify various materials science phenomena. The recent progress in open…

Materials Science · Physics 2025-03-25 Balduin Katzer , Steffen Klinder , Katrin Schulz

The exponential growth of AI in science necessitates efficient and scalable solutions for retrieving and preserving research information. Here, we present a tool for the development of a customized question-answer (QA) dataset, called…

Information Retrieval · Computer Science 2025-02-25 Qiming Liu , Zhongzheng Niu , Siting Liu , Mao Tian

By simply composing prompts, developers can prototype novel generative applications with Large Language Models (LLMs). To refine prototypes into products, however, developers must iteratively revise prompts by evaluating outputs to diagnose…

Human-Computer Interaction · Computer Science 2024-02-28 Tae Soo Kim , Yoonjoo Lee , Jamin Shin , Young-Ho Kim , Juho Kim

Automatic survey generation has emerged as a key task in scientific document processing. While large language models (LLMs) have shown promise in generating survey texts, the lack of standardized evaluation datasets critically hampers…

Computation and Language · Computer Science 2025-08-26 Tong Bao , Mir Tafseer Nayeem , Davood Rafiei , Chengzhi Zhang

Integrating external tools into Large Foundation Models (LFMs) has emerged as a promising approach to enhance their problem-solving capabilities. While existing studies have demonstrated strong performance in tool-augmented Visual Question…

Artificial Intelligence · Computer Science 2026-03-05 Shaofeng Yin , Ting Lei , Yang Liu

Recently, ultra high-throughput sequencing of RNA (RNA-Seq) has been developed as an approach for analysis of gene expression. By obtaining tens or even hundreds of millions of reads of transcribed sequences, an RNA-Seq experiment can offer…

Methodology · Statistics 2011-06-17 Julia Salzman , Hui Jiang , Wing Hung Wong

The emergence of R, a freely available data analysis environment, brought to the researcher in any science field a set of well-concerted instruments of immense power and low cost. In botany and zoology, these instruments could be used, for…

Quantitative Methods · Quantitative Biology 2020-02-06 Alexey Shipunov

This paper introduces AQA-Bench, a novel benchmark to assess the sequential reasoning capabilities of large language models (LLMs) in algorithmic contexts, such as depth-first search (DFS). The key feature of our evaluation benchmark lies…

Computation and Language · Computer Science 2025-06-23 Siwei Yang , Bingchen Zhao , Cihang Xie

Evaluating multiple-choice questions (MCQs) involves either labor intensive human assessments or automated methods that prioritize readability, often overlooking deeper question design flaws. To address this issue, we introduce the Scalable…

Artificial Intelligence · Computer Science 2024-06-03 Steven Moore , Eamon Costello , Huy A. Nguyen , John Stamper

Large Language Models (LLMs) have revolutionized the ability to understand and generate text, enabling significant progress in automatic knowledge graph construction from text (Text2KG). Many Text2KG methods, however, rely on iterative LLM…

Computation and Language · Computer Science 2025-12-04 Faezeh Faez , Marzieh S. Tahaei , Yaochen Hu , Ali Pourranjbar , Mahdi Biparva , Mark Coates , Yingxue Zhang

High-throughput sequencing is now regularly used for studies of the transcriptome (RNA-seq), particularly for comparisons among experimental conditions. For the time being, a limited number of biological replicates are typically considered…

Applications · Statistics 2013-06-18 Andrea Rau , Guillemette Marot , Florence Jaffrézic

Large Language Models (LLMs) excel at generating synthetic data, but ensuring its quality and diversity remains challenging. We propose Genetic Prompt, a novel framework that combines genetic algorithms with LLMs to augment synthetic data…

Computation and Language · Computer Science 2025-09-03 Guangzeng Han , Weisi Liu , Xiaolei Huang

Generative machine learning models for exploring chemical space have shown immense promise, but many molecules they generate are too difficult to synthesize, making them impractical for further investigation or development. In this work, we…

A Language Model is a term that encompasses various types of models designed to understand and generate human communication. Large Language Models (LLMs) have gained significant attention due to their ability to process text with human-like…

Computation and Language · Computer Science 2024-06-12 Sylvio Barbon Junior , Paolo Ceravolo , Sven Groppe , Mustafa Jarrar , Samira Maghool , Florence Sèdes , Soror Sahri , Maurice Van Keulen

Contemporary spatial services such as online maps predominantly rely on user queries for location searches. However, the user experience is limited when performing complex tasks, such as searching for a group of locations simultaneously. In…

Artificial Intelligence · Computer Science 2025-08-15 Ivan Khai Ze Lim , Ningyi Liao , Yiming Yang , Gerald Wei Yong Yip , Siqiang Luo

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Most public instruction finetuning datasets are relatively small compared to the closed source datasets used to train industry models. To study questions about finetuning at scale, such as curricula and learning rate cooldown schedules,…

Computation and Language · Computer Science 2024-06-18 Jiuhai Chen , Rifaa Qadri , Yuxin Wen , Neel Jain , John Kirchenbauer , Tianyi Zhou , Tom Goldstein

Nanopore sequencing technology has the potential to render other sequencing technologies obsolete with its ability to generate long reads and provide portability. However, high error rates of the technology pose a challenge while generating…

Genomics · Quantitative Biology 2019-12-20 Damla Senol Cali , Jeremie S. Kim , Saugata Ghose , Can Alkan , Onur Mutlu

Clinical Question Answering (QA) systems enable doctors to quickly access patient information from electronic health records (EHRs). However, training these systems requires significant annotated data, which is limited due to the expertise…

Computation and Language · Computer Science 2024-12-09 Fan Bai , Keith Harrigian , Joel Stremmel , Hamid Hassanzadeh , Ardavan Saeedi , Mark Dredze