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Motivation: Single-cell RNA sequencing (scRNA-seq) is a groundbreaking technology extensively utilized in biological research, facilitating the examination of gene expression at the individual cell level within a given tissue sample. While…

Machine Learning · Computer Science 2024-04-10 Shengze Dong , Zhuorui Cui , Ding Liu , Jinzhi Lei

Natural Language Processing (NLP) is widely used to supply summarization ability from long context to structured information. However, extracting structured knowledge from scientific text by NLP models remains a challenge because of its…

Computation and Language · Computer Science 2024-12-10 Tong Xie , Hanzhi Zhang , Shaozhou Wang , Yuwei Wan , Imran Razzak , Chunyu Kit , Wenjie Zhang , Bram Hoex

Large Language Models (LLMs) are increasingly utilized for large-scale extraction and organization of unstructured data owing to their exceptional Natural Language Processing (NLP) capabilities. Empowering materials design, vast amounts of…

Digital Libraries · Computer Science 2025-12-11 Wenkai Ning , Musen Li , Jeffrey R. Reimers , Rika Kobayashi

This research pioneers the use of fine-tuned Large Language Models (LLMs) to automate Systematic Literature Reviews (SLRs), presenting a significant and novel contribution in integrating AI to enhance academic research methodologies. Our…

Computation and Language · Computer Science 2025-02-21 Teo Susnjak , Peter Hwang , Napoleon H. Reyes , Andre L. C. Barczak , Timothy R. McIntosh , Surangika Ranathunga

Unstructured text has long been difficult to automatically analyze at scale. Large language models (LLMs) now offer a way forward by enabling {\em semantic data processing}, where familiar data processing operators (e.g., map, reduce,…

Human-Computer Interaction · Computer Science 2025-04-22 Shreya Shankar , Bhavya Chopra , Mawil Hasan , Stephen Lee , Björn Hartmann , Joseph M. Hellerstein , Aditya G. Parameswaran , Eugene Wu

The alignment of biological sequences such as DNA, RNA, and proteins, is one of the basic tools that allow to detect evolutionary patterns, as well as functional/structural characterizations between homologous sequences in different…

Quantitative Methods · Quantitative Biology 2023-05-01 Louise Budzynski , Andrea Pagnani

Investigative journalists routinely confront large document collections. Large language models (LLMs) with retrieval-augmented generation (RAG) capabilities promise to accelerate the process of document discovery, but newsroom adoption…

Information Retrieval · Computer Science 2025-10-01 Nick Hagar , Nicholas Diakopoulos , Jeremy Gilbert

Large language models (LLMs) have shown impressive promise in code generation, yet their progress remains limited by the shortage of large-scale datasets that are both diverse and well-aligned with human reasoning. Most existing resources…

Machine Learning · Computer Science 2025-10-28 Amal Abed , Ivan Lukic , Jörg K. H. Franke , Frank Hutter

With the advent of Next-Generation (NG) sequencing, it has become possible to sequence an entire genome quickly and inexpensively. However, in some experiments one only needs to extract and assembly a portion of the sequence reads, for…

Genomics · Quantitative Biology 2013-08-01 Ilya Y. Zhbannikov , Samuel S. Hunter , Matthew L. Settles , James A. Foster

The prediction of chemical synthesis pathways plays a pivotal role in materials science research. Challenges, such as the complexity of synthesis pathways and the lack of comprehensive datasets, currently hinder our ability to predict these…

Materials Science · Physics 2023-11-03 Ziyi Chen , Fankai Xie , Meng Wan , Yang Yuan , Miao Liu , Zongguo Wang , Sheng Meng , Yangang Wang

Conversational user interfaces powered by large language models (LLMs) have significantly lowered the technical barriers to database querying. However, existing tools still encounter several challenges, such as misinterpretation of user…

Human-Computer Interaction · Computer Science 2025-08-22 Longfei Chen , Shenghan Gao , Shiwei Wang , Ken Lin , Yun Wang , Quan Li

Creation of large-scale databases for Visual Question Answering tasks pertaining to the text data in a scene (text-VQA) involves skilful human annotation, which is tedious and challenging. With the advent of foundation models that handle…

Computer Vision and Pattern Recognition · Computer Science 2025-11-05 Soham Joshi , Shwet Kamal Mishra , Viswanath Gopalakrishnan

Table Question Answering (TQA) aims to answer natural language questions over structured tables. Large Language Models (LLMs) enable promising solutions to this problem, with operator-centric solutions that generate table manipulation…

Databases · Computer Science 2026-04-02 Fengyu Li , Junhao Zhu , Kaishi Song , Lu Chen , Zhongming Yao , Tianyi Li , Christian S. Jensen

Evaluating outputs of large language models (LLMs) is challenging, requiring making -- and making sense of -- many responses. Yet tools that go beyond basic prompting tend to require knowledge of programming APIs, focus on narrow domains,…

Human-Computer Interaction · Computer Science 2024-05-07 Ian Arawjo , Chelse Swoopes , Priyan Vaithilingam , Martin Wattenberg , Elena Glassman

This paper introduces LLAssist, an open-source tool designed to streamline literature reviews in academic research. In an era of exponential growth in scientific publications, researchers face mounting challenges in efficiently processing…

Digital Libraries · Computer Science 2024-12-23 Christoforus Yoga Haryanto

Supervised fine-tuning (SFT) is a standard approach for adapting large language models to specialized domains, yet its application to protein sequence modeling and protein language models (PLMs) remains ad hoc. This is in part because…

Machine Learning · Computer Science 2025-12-11 Amin Tavakoli , Raswanth Murugan , Ozan Gokdemir , Arvind Ramanathan , Frances Arnold , Anima Anandkumar

Large Language Models (LLMs) have showcased their remarkable capabilities in diverse domains, encompassing natural language understanding, translation, and even code generation. The potential for LLMs to generate harmful content is a…

Software Engineering · Computer Science 2024-09-17 Mingke Yang , Yuqi Chen , Yi Liu , Ling Shi

Natural Question Answering (QA) datasets play a crucial role in evaluating the capabilities of large language models (LLMs), ensuring their effectiveness in real-world applications. Despite the numerous QA datasets that have been developed…

Computational complexity is a key limitation of genomic analyses. Thus, over the last 30 years, researchers have proposed numerous fast heuristic methods that provide computational relief. Comparing genomic sequences is one of the most…

Large Language Models, particularly decoder-only generative models such as GPT, are increasingly used to automate Software Engineering tasks. These models are primarily guided through natural language prompts, making prompt engineering a…

Software Engineering · Computer Science 2026-01-06 Alexander Korn , Lea Zaruchas , Chetan Arora , Andreas Metzger , Sven Smolka , Fanyu Wang , Andreas Vogelsang
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