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Positron emission tomography (PET) is an important functional medical imaging technique often used in the evaluation of certain brain disorders, whose reconstruction problem is ill-posed. The vast majority of reconstruction methods in PET…

Image and Video Processing · Electrical Eng. & Systems 2023-06-09 Tin Vlašić , Tomislav Matulić , Damir Seršić

Background: In medical imaging, images are usually treated as deterministic, while their uncertainties are largely underexplored. Purpose: This work aims at using deep learning to efficiently estimate posterior distributions of imaging…

Image and Video Processing · Electrical Eng. & Systems 2023-03-20 Xiaofeng Liu , Thibault Marin , Tiss Amal , Jonghye Woo , Georges El Fakhri , Jinsong Ouyang

Cardiovascular magnetic resonance imaging is a powerful diagnostic tool for assessing cardiac structure and function. However, traditional breath-held imaging protocols pose challenges for patients with arrhythmias or limited breath-holding…

Dual-energy X-ray Computed Tomography (DECT) constitutes an advanced technology which enables automatic decomposition of materials in clinical images without manual segmentation using the dependency of the X-ray linear attenuation with…

Image and Video Processing · Electrical Eng. & Systems 2025-07-25 Hang Xu , Alexandre Bousse , Alessandro Perelli

The deep image prior (DIP) is a well-established unsupervised deep learning method for image reconstruction; yet it is far from being flawless. The DIP overfits to noise if not early stopped, or optimized via a regularized objective. We…

Image and Video Processing · Electrical Eng. & Systems 2023-05-16 Marco Nittscher , Michael Lameter , Riccardo Barbano , Johannes Leuschner , Bangti Jin , Peter Maass

List-mode positron emission tomography (PET) image reconstruction is an important tool for PET scanners with many lines-of-response and additional information such as time-of-flight and depth-of-interaction. Deep learning is one possible…

Medical Physics · Physics 2024-02-13 Kibo Ote , Fumio Hashimoto , Yuya Onishi , Takashi Isobe , Yasuomi Ouchi

Recent work has shown that the structure of convolutional neural networks (CNNs) induces a strong prior that favors natural images. This prior, known as a deep image prior (DIP), is an effective regularizer in inverse problems such as image…

Computer Vision and Pattern Recognition · Computer Science 2020-12-03 Pallabi Ghosh , Vibhav Vineet , Larry S. Davis , Abhinav Shrivastava , Sudipta Sinha , Neel Joshi

Prediction of toxicity levels of chemical compounds is an important issue in Quantitative Structure-Activity Relationship (QSAR) modeling. Although toxicity prediction has achieved significant progress in recent times through deep learning,…

Machine Learning · Computer Science 2019-07-22 Abdul Karim , Jaspreet Singh , Avinash Mishra , Abdollah Dehzangi , M. A. Hakim Newton , Abdul Sattar

We extend the Deep Image Prior (DIP) framework to one-dimensional signals. DIP is using a randomly initialized convolutional neural network (CNN) to solve linear inverse problems by optimizing over weights to fit the observed measurements.…

Machine Learning · Computer Science 2019-04-19 Sriram Ravula , Alexandros G. Dimakis

Reconstructing magnetization in nanoscale magnetic thin films is essential for developing next-generation memory, sensors, and various spintronic technologies. However, this remains challenging due to the ill-posed nature of the stray field…

Disordered Systems and Neural Networks · Physics 2026-04-28 Zander Scholl , Justin Woods , Charudatta Phatak , Hanu Arava

Predicting drug side-effects before they occur is a key task in keeping the number of drug-related hospitalizations low and to improve drug discovery processes. Automatic predictors of side-effects generally are not able to process the…

Machine Learning · Statistics 2022-12-01 Pietro Bongini , Elisa Messori , Niccolò Pancino , Monica Bianchini

In recent years, there has been an explosion of research on the application of deep learning to the prediction of various peptide properties, due to the significant development and market potential of peptides. Molecular dynamics has…

Biomolecules · Quantitative Biology 2023-07-19 Zihan Liu , Jiaqi Wang , Yun Luo , Shuang Zhao , Wenbin Li , Stan Z. Li

Stochastic variational inference for Bayesian deep neural network (DNN) requires specifying priors and approximate posterior distributions over neural network weights. Specifying meaningful weight priors is a challenging problem,…

Neural and Evolutionary Computing · Computer Science 2020-01-01 Ranganath Krishnan , Mahesh Subedar , Omesh Tickoo

The knowledge of potentially druggable binding sites on proteins is an important preliminary step towards the discovery of novel drugs. The computational prediction of such areas can be boosted by following the recent major advances in the…

Biomolecules · Quantitative Biology 2021-02-17 Stelios K. Mylonas , Apostolos Axenopoulos , Petros Daras

Diffusion models have shown great promise in medical image denoising and reconstruction, but their application to Positron Emission Tomography (PET) imaging remains limited by tracer-specific contrast variability and high computational…

Image and Video Processing · Electrical Eng. & Systems 2026-02-03 Fumio Hashimoto , Kuang Gong

Designing accurate deep learning models for molecular property prediction plays an increasingly essential role in drug and material discovery. Recently, due to the scarcity of labeled molecules, self-supervised learning methods for learning…

Biomolecules · Quantitative Biology 2022-06-08 Han Li , Dan Zhao , Jianyang Zeng

We propose a novel method for compressed sensing recovery using untrained deep generative models. Our method is based on the recently proposed Deep Image Prior (DIP), wherein the convolutional weights of the network are optimized to match…

The unprecedented success of image reconstruction approaches based on deep neural networks has revolutionised both the processing and the analysis paradigms in several applied disciplines. In the field of digital humanities, the task of…

Computer Vision and Pattern Recognition · Computer Science 2023-12-14 Fabio Merizzi , Perrine Saillard , Oceane Acquier , Elena Morotti , Elena Loli Piccolomini , Luca Calatroni , Rosa Maria Dessì

Deep image prior (DIP) proposed in recent research has revealed the inherent trait of convolutional neural networks (CNN) for capturing substantial low-level image statistics priors. This framework efficiently addresses the inverse problems…

Computer Vision and Pattern Recognition · Computer Science 2024-04-19 Ziyu Shu , Zhixin Pan

Dual-energy computed tomography (DECT) enables material-specific imaging through acquisitions at two different X-ray energy spectra. Material decomposition from DECT data is an ill-posed inverse problem that is highly sensitive to noise…