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Transcranial ultrasonic stimulation (TUS) has the potential to usher in a new era for human neuroscience by allowing spatially precise and high-resolution non-invasive targeting of both deep and superficial brain regions. Currently,…

Low-intensity Transcranial Ultrasonic Stimulation (TUS) is a non-invasive brain stimulation technique enabling cortical and deep brain targeting with unprecedented spatial accuracy. Given the high rate of adoption by new users with varying…

As transcranial ultrasound stimulation (TUS) advances as a precise, non-invasive neuromodulatory method, there is a need for consistent reporting standards to enable comparison and reproducibility across studies. To this end, the…

Objective. While ultrasound is largely established for use in diagnostic imaging and heating therapies, its application for neuromodulation is relatively new and not well understood. The objective of the present study was to investigate…

Tissues and Organs · Quantitative Biology 2015-03-09 Jerel K. Mueller , Wynn Legon , William J. Tyler

Transcranial magnetic stimulation (TMS) is a technique for noninvasively stimulating a brain area for therapeutic, rehabilitation treatments and neuroscience research. Despite our understanding of the physical principles and experimental…

Neurons and Cognition · Quantitative Biology 2020-12-30 Jose Gomez-Tames , Ilkka Laakso , Akimasa Hirata

Low-intensity transcranial focused ultrasound (tFUS) is rapidly emerging as a transformative non-invasive brain stimulation (NIBS) modality characterized by high spatial resolution and ability to target deep brain circuits. Unlike…

Neurons and Cognition · Quantitative Biology 2026-04-02 William J. Tyler

For decades, focal non-invasive neuromodulation of deep brain regions has not been possible because of the steep depth-focality trade-off of conventional non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic…

Neurons and Cognition · Quantitative Biology 2025-12-17 Pierre Vassiliadis , Elena Beanato , Maximilian J. Wessel , Friedhelm C. Hummel

Objective. Personalized transcranial electrical stimulation (tES) has gained growing attention due to the substantial inter-individual variability in brain anatomy and physiology. While previous reviews have discussed the physiological…

Neurons and Cognition · Quantitative Biology 2025-11-06 Mo Wang , Kexin Zheng , Yingyue Xin , Xiang Chen , Yiling Liu , Huichun Luo , Jingsheng Tang , Tifei Yuan , Hongkai Wen , Pengfei Wei , Quanying Liu

Transcranial focused ultrasound (tFUS) is an emerging form of non-surgical human neuromodulation that confers advantages over existing electro and electromagnetic technologies by providing a superior spatial resolution on the millimeter…

Neurons and Cognition · Quantitative Biology 2016-03-02 Leo Ai , Jerel K. Mueller , Andrea Grant , Yigitcan Eryaman , Wynn Legon

Identifying what aspects of brain activity are responsible for conscious perception remains one of the most challenging problems in science. While progress has been made through psychophysical studies employing EEG and fMRI, research would…

Neurons and Cognition · Quantitative Biology 2025-07-14 Daniel K. Freeman , Brian Odegaard , Seung-Schik Yoo , Matthias Michel

Focused ultrasound spinal cord neuromodulation studies have demonstrated spinal cord neuromodulation in small animals. The safe and efficacious translation of these approaches to human scale requires an understanding of ultrasound…

Medical Physics · Physics 2024-02-23 Rui Xu , Sven Bestmann , Bradley E. Treeby , Eleanor Martin

Background: Trans-spinal FUS (tsFUS) has recently been shown promise in modulating spinal reflexes in rodents, opening new avenues for spinal cord interventions in motor control and pain management. However, anatomical differences between…

Medical Physics · Physics 2025-07-09 Koharu Isomura , Wenwei Yu , Jose Gomez-Tames

Transcranial focused ultrasound stimulation (TUS) holds promise for non-invasive neural modulation in treating neurological disorders. Most clinically relevant targets are deep within the brain (near or at its geometric center), surrounded…

Low-intensity focused transcranial ultrasonic stimulation (TUS) offers unique depth and precision in non-invasive brain stimulation. Effective administration of TUS, however, requires precise placement of transducers to ensure selective…

Biological Physics · Physics 2025-07-01 Maximilian Lueckel , Suhas Vijayakumar , Til Ole Bergmann

Transcranial ultrasound is more and more used for therapy and imaging of the brain. However, the skull is a highly attenuating and aberrating medium, with different structures and acoustic properties between samples and even within a…

Medical Physics · Physics 2022-07-26 Celestine Angla , Benoit Larrat , Jean-Luc Gennisson , Sylvain Chatillon

Personalized treatments are gaining momentum across all fields of medicine. Precision medicine can be applied to neuromodulatory techniques, where focused brain stimulation treatments such as repetitive transcranial magnetic stimulation…

Peripheral Nerve Stimulation (PNS) constrains the clinical performance of Magnetic Resonance and Particle Imaging (MRI and MPI) systems. Extensive magneto-stimulation studies have been carried out recently in the field of MPI, where typical…

Medical ultrasound imaging relies heavily on high-quality signal processing to provide reliable and interpretable image reconstructions. Conventionally, reconstruction algorithms where derived from physical principles. These algorithms rely…

Signal Processing · Electrical Eng. & Systems 2023-09-21 Ben Luijten , Nishith Chennakeshava , Yonina C. Eldar , Massimo Mischi , Ruud J. G. van Sloun

Medical ultrasound imaging is the most widespread real-time non-invasive imaging system and its formulation comprises signal transmission, signal reception, and image formation. Ultrasound signal transmission modelling has been formalized…

Numerical Analysis · Mathematics 2023-08-09 Chiara Razzetta , Valentina Candiani , Marco Crocco , Federico Benvenuto

Background: Transcranial magnetic stimulation (TMS) is a powerful tool to investigate neurophysiology of the human brain and treat brain disorders. Traditionally, therapeutic TMS has been applied in a one-size-fits-all approach,…

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