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Functional connectivity (FC) between brain regions tracks symptom severity in many neuropsychiatric disorders. Transcranial magnetic stimulation (TMS) directly alters regional activity and indirectly alters FC. Predicting how FC will change…

Neurons and Cognition · Quantitative Biology 2022-08-25 Andrew C. Murphy , Romain Duprat , Theodore D. Satterthwaite , Desmond J. Oathes , Dani S. Bassett

Objective: The objective of this study is to develop and evaluate a systematic approach to optimize Deep Brain Stimulation (DBS) parameters, addressing the challenge of identifying patient-specific settings and optimal stimulation targets…

Systems and Control · Electrical Eng. & Systems 2026-01-13 Anna Franziska Frigge , Lina Uggla , Elena Jiltsova , Markus Fahlström , Dag Nyholm , Alexander Medvedev

High density neurostimulation systems are coming to market to help spinal cord injury patients by stimulating and recording neuromuscular function. However, the parameter space that these systems have to explore is exceedingly large, and…

Signal Processing · Electrical Eng. & Systems 2021-12-06 Dhruv Pai , Mentor Kip Ludwig

Targeted electrical stimulation of the brain perturbs neural networks and modulates their rhythmic activity both at the site of stimulation and at remote brain regions. Understanding, or even predicting, this neuromodulatory effect is…

Neurons and Cognition · Quantitative Biology 2021-06-29 Christoforos Papasavvas , Peter Neal Taylor , Yujiang Wang

Non-invasive brain stimulation, such as transcranial alternating current stimulation (tACS) provides a powerful tool to directly modulate brain oscillations that mediate complex cognitive processes. While the body of evidence about the…

The presentation of a moving tactile stimulus to a person's forearm evokes a pleasant sensation. The speed, intensity, and contact area of the strokes should be systematically changed to evaluate the relationship between pleasantness and…

Human-Computer Interaction · Computer Science 2023-05-17 Sora Satake , Yoshihiro Nagano , Masashi Sugiyama , Masahiro Fujiwara , Yasutoshi Makino , Hiroyuki Shinoda

Computational models of acoustic wave propagation are frequently used in transcranial ultrasound therapy, for example, to calculate the intracranial pressure field or to calculate phase delays to correct for skull distortions. To allow…

Neural responses are highly variable, and some portion of this variability arises from fluctuations in modulatory factors that alter their gain, such as adaptation, attention, arousal, expected or actual reward, emotion, and local metabolic…

Neurons and Cognition · Quantitative Biology 2015-07-08 Neil C. Rabinowitz , Robbe L. T. Goris , Johannes Ballé , Eero P. Simoncelli

Neurostimulation technologies have seen a recent surge in interest from the neuroscience and controls communities alike due to their proven potential to treat conditions such as Parkinson's Disease, and depression. The provided stimulation…

Systems and Control · Electrical Eng. & Systems 2023-01-03 Gagan Acharya , Sebastian F. Ruf , Erfan Nozari

Transcranial photobiomodulation (tPBM) therapy is an emerging, non-invasive neuromodulation technique that has demonstrated considerable potential in the field of neuropsychiatric disorders. Several studies have found that pulsed wave (PW)…

Neurons and Cognition · Quantitative Biology 2025-12-02 Jiangshan He , Hui Xie , Yuqiang Yang , Chunli Jia , Dan Liang , Lianghua Zhang , Xiaoyu Wang , Tianyi Luo , Zexiao Dong , Huiting Yang , Zhen Yuan , Mingzhe Jiang , Xueli Chen

The ability to modulate brain states using targeted stimulation is increasingly being employed to treat neurological disorders and to enhance human performance. Despite the growing interest in brain stimulation as a form of neuromodulation,…

Neurons and Cognition · Quantitative Biology 2016-01-07 Sarah Feldt Muldoon , Fabio Pasqualetti , Shi Gu , Matthew Cieslak , Scott T. Grafton , Jean M. Vettel , Danielle S. Bassett

The objective of this study was to characterize hemodynamic changes during trans-vascular stimulation of the renal nerve and their dependence on stimulation parameters. We employed a stimulation catheter inserted in the right renal artery…

Quantitative Methods · Quantitative Biology 2024-06-06 Filippo Agnesi , Lucia Carlucci , Gia Burjanadze , Fabio Bernini , Khatia Gabisonia , John W Osborn , Silvestro Micera , Fabio A. Recchia

Identifying stimulus-driven neural activity patterns is critical for studying the neural basis of cognition. This can be particularly challenging in intracranial datasets, where electrode locations typically vary across patients. This…

Neurons and Cognition · Quantitative Biology 2022-02-07 Jeremy R. Manning

Accurate neuronavigation is critical for effective transcranial magnetic stimulation (TMS), as stimulation outcomes depend directly on precise coil placement. Existing neuronavigation systems are often costly, complex, and prone to tracking…

Human-Computer Interaction · Computer Science 2026-01-26 Xuyi Hu , Ke Ma , Siwei Liu , Per Ola Kristensson , Stefan Goetz

Transcranial magnetic stimulation (TMS) is a noninvasive medical procedure that can modulate brain activity, and it is widely used in neuroscience and neurology research. Compared to manual operators, robots may improve the outcome of TMS…

Transcranial focused ultrasound (FUS) is a non-invasive technique for therapy and study of brain neural activation. Here we report on the design and characterization of a new MR-guided FUS transducer for neuromodulation in non-human…

Medical Physics · Physics 2018-06-13 Vandiver Chaplin , Marshal A. Phipps , Charles F. Caskey

Neurotechnologies are transforming how we measure, interpret, and modulate brain-body interactions, integrating real-time sensing, computation, and stimulation to enable precise physiological control. They hold transformative potential…

Transcranial ultrasound simulations are increasingly used to predict in situ exposure parameters for ultrasound therapies in the brain. However, there can be considerable uncertainty in estimating the acoustic medium properties of the skull…

Medical Physics · Physics 2022-12-09 Antonio Stanziola , José A. Pineda-Pardo , Bradley Treeby

The coupling of human movement dynamics with the function and design of wearable assistive devices is vital to better understand the interaction between the two. Advanced neuromuscular models and optimal control formulations provide the…

Robotics · Computer Science 2018-04-10 Manish Sreenivasa , Matthew Millard , Paul Manns , Katja Mombaur

This article describes a numerical procedure designed to tune the parameters of periodically-driven dynamical systems to a state in which they exhibit rich dynamical behavior. This is achieved by maximizing the diversity of subharmonic…

Chaotic Dynamics · Physics 2017-02-13 Leandro M. Alonso