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Current AI systems achieve impressive performance on many tasks, yet they lack core attributes of biological intelligence, including rapid, continual learning, representations grounded in sensorimotor interactions, and structured knowledge…

Artificial Intelligence · Computer Science 2025-07-08 Niels Leadholm , Viviane Clay , Scott Knudstrup , Hojae Lee , Jeff Hawkins

The multi-level method for discrete state systems, first introduced by Anderson and Higham [Multiscale Model. Simul. 10:146--179, 2012], is a highly efficient simulation technique that can be used to elucidate statistical characteristics of…

Quantitative Methods · Quantitative Biology 2016-09-06 Christopher Lester , Ruth E. Baker , Michael B. Giles , Christian A. Yates

All simulation approaches eventually face limits in computational scalability when applied to large spatiotemporal domains. This challenge becomes especially apparent in molecular-level particle simulations, where high spatial and temporal…

Computational Physics · Physics 2025-10-23 Matthias Busch , Gregor Häfner , Jiayu Xie , Marius Tacke , Marcus Müller , Christian J. Cyron , Roland C. Aydin

Recent advancements in deep learning have shifted the development of brain imaging analysis. However, several challenges remain, such as heterogeneity, individual variations, and the contradiction between the high dimensionality and small…

Computer Vision and Pattern Recognition · Computer Science 2024-07-24 Yanwu Yang , Hairui Chen , Jiesi Hu , Xutao Guo , Ting Ma

We present a keypoint-based foundation model for general purpose brain MRI registration, based on the recently-proposed KeyMorph framework. Our model, called BrainMorph, serves as a tool that supports multi-modal, pairwise, and scalable…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Alan Q. Wang , Rachit Saluja , Heejong Kim , Xinzi He , Adrian Dalca , Mert R. Sabuncu

As numerical simulations grow in size and complexity, they become increasingly resource-intensive in terms of time and energy. While specialized hardware accelerators often provide order-of-magnitude gains and are state of the art in other…

Neural and Evolutionary Computing · Computer Science 2024-12-04 Hartmut Schmidt , Andreas Grübl , José Montes , Eric Müller , Sebastian Schmitt , Johannes Schemmel

Mental and cognitive representations are believed to reside on low-dimensional, non-linear manifolds embedded within high-dimensional brain activity. Uncovering these manifolds is key to understanding individual differences in brain…

Machine Learning · Computer Science 2025-05-02 Eloy Geenjaar , Vince Calhoun

Neurons encode information in a binary manner and process complex signals. However, predicting or generating diverse neural activity patterns remains challenging. In vitro and in vivo studies provide distinct advantages, yet no robust…

Quantitative Methods · Quantitative Biology 2025-03-28 Masanori Shimono

Deep learning has led to significant advances in artificial intelligence, in part, by adopting strategies motivated by neurophysiology. However, it is unclear whether deep learning could occur in the real brain. Here, we show that a deep…

Neurons and Cognition · Quantitative Biology 2017-04-11 Jordan Guergiuev , Timothy P. Lillicrap , Blake A. Richards

We present first experimental results on the novel BrainScaleS-2 neuromorphic architecture based on an analog neuro-synaptic core and augmented by embedded microprocessors for complex plasticity and experiment control. The high acceleration…

This paper introduces decentralized and modular neural network framework designed to enhance the scalability, interpretability, and performance of artificial intelligence (AI) systems. At the heart of this framework is a dynamic switch…

Neural and Evolutionary Computing · Computer Science 2025-04-28 Surajit Majumder , Paritosh Ranjan , Prodip Roy , Bhuban Padhan

We explore and evaluate the interactions between Behavioral Programming (BP) and a range of Artificial Intelligence (AI) and Formal Methods (FM) techniques. Our goal is to demonstrate that BP can serve as an abstraction that integrates…

Software Engineering · Computer Science 2025-07-25 Tom Yaacov , Gera Weiss , Adiel Ashrov , Guy Katz , Jules Zisser

Spiking Neural Networks (SNNs) are considered to have enormous potential in the future development of Artificial Intelligence due to their brain-inspired and energy-efficient properties. Compared to vanilla Spatial-Temporal Back-propagation…

Neural and Evolutionary Computing · Computer Science 2026-03-10 Zecheng Hao , Yifan Huang , Zijie Xu , Wenxuan Liu , Yuanhong Tang , Zhaofei Yu , Tiejun Huang

Differentiable programming has recently received much interest as a paradigm that facilitates taking gradients of computer programs. While the corresponding flexible gradient-based optimization approaches so far have been used predominantly…

Diffusion probabilistic models (DPMs) have exhibited significant effectiveness in computer vision tasks, particularly in image generation. However, their notable performance heavily relies on labelled datasets, which limits their…

Computer Vision and Pattern Recognition · Computer Science 2024-05-09 Keqiang Fan , Xiaohao Cai , Mahesan Niranjan

In this work, we propose a learning framework for identifying synapses using a deep and wide multi-scale recursive (DAWMR) network, previously considered in image segmentation applications. We apply this approach on electron microscopy data…

Computer Vision and Pattern Recognition · Computer Science 2014-09-08 Gary B. Huang , Stephen Plaza

The network architecture of the human brain has become a feature of increasing interest to the neuroscientific community, largely because of its potential to illuminate human cognition, its variation over development and aging, and its…

Neurons and Cognition · Quantitative Biology 2016-11-07 Richard F. Betzel , Danielle S. Bassett

In this work, we introduce a novel computational framework that we developed to use numerical simulations to investigate the complexity of brain tissue at a microscopic level with a detail never realised before. Directly inspired by the…

Medical Physics · Physics 2018-06-20 Marco Palombo , Daniel C. Alexander , Hui Zhang

Cortical synapse organization supports a range of dynamic states on multiple spatial and temporal scales, from synchronous slow wave activity (SWA), characteristic of deep sleep or anesthesia, to fluctuating, asynchronous activity during…

Neural and Evolutionary Computing · Computer Science 2019-11-27 Elena Pastorelli , Cristiano Capone , Francesco Simula , Maria V. Sanchez-Vives , Paolo Del Giudice , Maurizio Mattia , Pier Stanislao Paolucci

Deep learning methods have shown great promise in many practical applications, ranging from speech recognition, visual object recognition, to text processing. However, most of the current deep learning methods suffer from scalability…

Machine Learning · Statistics 2015-08-31 Yanping Huang , Sai Zhang