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A key issue in critical contexts such as medical diagnosis is the interpretability of the deep learning models adopted in decision-making systems. Research in eXplainable Artificial Intelligence (XAI) is trying to solve this issue. However,…

Computer Vision and Pattern Recognition · Computer Science 2021-11-24 Carlo Metta , Andrea Beretta , Riccardo Guidotti , Yuan Yin , Patrick Gallinari , Salvatore Rinzivillo , Fosca Giannotti

The differential diagnosis of neurodegenerative dementias is a challenging clinical task, mainly because of the overlap in symptom presentation and the similarity of patterns observed in structural neuroimaging. To improve diagnostic…

Machine Learning · Computer Science 2025-05-27 Andrew Zamai , Nathanael Fijalkow , Boris Mansencal , Laurent Simon , Eloi Navet , Pierrick Coupe

Counterfactual explanations are gaining prominence within technical, legal, and business circles as a way to explain the decisions of a machine learning model. These explanations share a trait with the long-established "principal reason"…

Computers and Society · Computer Science 2019-12-12 Solon Barocas , Andrew D. Selbst , Manish Raghavan

Causal modeling has been recognized as a potential solution to many challenging problems in machine learning (ML). Here, we describe how a recently proposed counterfactual approach developed to deconfound linear structural causal models can…

Machine Learning · Computer Science 2020-11-23 Elias Chaibub Neto

Although machine learning (ML) models of AI achieve high performances in medicine, they are not free of errors. Empowering clinicians to identify incorrect model recommendations is crucial for engendering trust in medical AI. Explainable AI…

Artificial Intelligence · Computer Science 2022-12-20 Isil Guzey , Ozlem Ucar , Nukhet Aladag Ciftdemir , Betul Acunas

The automation of the medical evidence acquisition and diagnosis process has recently attracted increasing attention in order to reduce the workload of doctors and democratize access to medical care. However, most works proposed in the…

Computation and Language · Computer Science 2022-10-14 Arsene Fansi Tchango , Rishab Goel , Julien Martel , Zhi Wen , Gaetan Marceau Caron , Joumana Ghosn

Explainable Artificial Intelligence (AI) in the form of an interpretable and semiautomatic approach to stage grading ocular pathologies such as Diabetic retinopathy, Hypertensive retinopathy, and other retinopathies on the backdrop of major…

Image and Video Processing · Electrical Eng. & Systems 2022-12-15 Ayushi Raj Bhatt , Rajkumar Vaghashiya , Meghna Kulkarni , Dr Prakash Kamaraj

As the field of healthcare increasingly adopts artificial intelligence, it becomes important to understand which types of explanations increase transparency and empower users to develop confidence and trust in the predictions made by…

Artificial Intelligence · Computer Science 2025-05-16 Felix Liedeker , Olivia Sanchez-Graillet , Moana Seidler , Christian Brandt , Jörg Wellmer , Philipp Cimiano

Deep learning models are widely used in traffic forecasting and have achieved state-of-the-art prediction accuracy. However, the black-box nature of those models makes the results difficult to interpret by users. This study aims to leverage…

Machine Learning · Computer Science 2025-12-16 Rushan Wang , Yanan Xin , Yatao Zhang , Fernando Perez-Cruz , Martin Raubal

Recent advancement in machine learning algorithms reaches a point where medical devices can be equipped with artificial intelligence (AI) models for diagnostic support and routine automation in clinical settings. In medicine and healthcare,…

Machine Learning · Statistics 2025-02-21 Takeshi Abe , Yoshiyuki Asai

Diagnosis prediction is a critical task in healthcare, where timely and accurate identification of medical conditions can significantly impact patient outcomes. Traditional machine learning and deep learning models have achieved notable…

Machine Learning · Computer Science 2025-01-09 Qiuhao Lu , Rui Li , Elham Sagheb , Andrew Wen , Jinlian Wang , Liwei Wang , Jungwei W. Fan , Hongfang Liu

This article presents the prediction difference analysis method for visualizing the response of a deep neural network to a specific input. When classifying images, the method highlights areas in a given input image that provide evidence for…

Computer Vision and Pattern Recognition · Computer Science 2017-02-16 Luisa M Zintgraf , Taco S Cohen , Tameem Adel , Max Welling

Artificial Intelligence (AI) increasingly shows its potential to outperform predicate logic algorithms and human control alike. In automatically deriving a system model, AI algorithms learn relations in data that are not detectable for…

Artificial Intelligence · Computer Science 2022-10-12 Simon Daniel Duque Anton , Daniel Schneider , Hans Dieter Schotten

The field of explainability in artificial intelligence (AI) has witnessed a growing number of studies and increasing scholarly interest. However, the lack of human-friendly and individual interpretations in explaining the outcomes of…

Artificial Intelligence · Computer Science 2025-02-04 Toygar Tanyel , Serkan Ayvaz , Bilgin Keserci

Machine learning technologies for protein function prediction are black box models. Despite their potential to identify key drug targets with high accuracy and accelerate therapy development, the adoption of these methods depends on…

Biomolecules · Quantitative Biology 2025-12-02 Ananya Krishna , Valentina Simon , Arjan Kohli

Deep Learning has shown outstanding results in computer vision tasks; healthcare is no exception. However, there is no straightforward way to expose the decision-making process of DL models. Good accuracy is not enough for skin cancer…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Rosa Y. G. Paccotacya-Yanque , Alceu Bissoto , Sandra Avila

Medical image classification is crucial for diagnosis and treatment, benefiting significantly from advancements in artificial intelligence. The paper reviews recent progress in the field, focusing on three levels of solutions: basic,…

Image and Video Processing · Electrical Eng. & Systems 2025-06-06 Loan Dao , Ngoc Quoc Ly

Deep neural networks for medical image classification often fail to generalize consistently in clinical practice due to violations of the i.i.d. assumption and opaque decision-making. This paper examines interpretability in deep neural…

Computer Vision and Pattern Recognition · Computer Science 2025-04-09 Mohammad Hossein Najafi , Mohammad Morsali , Mohammadreza Pashanejad , Saman Soleimani Roudi , Mohammad Norouzi , Saeed Bagheri Shouraki

Medical image classification is a critical problem for healthcare, with the potential to alleviate the workload of doctors and facilitate diagnoses of patients. However, two challenges arise when deploying deep learning models to real-world…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 An Yan , Yu Wang , Yiwu Zhong , Zexue He , Petros Karypis , Zihan Wang , Chengyu Dong , Amilcare Gentili , Chun-Nan Hsu , Jingbo Shang , Julian McAuley

Healthcare requires AI that is predictive, reliable, and data-efficient. However, recent generative models lack physical foundation and temporal reasoning required for clinical decision support. As scaling language models show diminishing…

Machine Learning · Computer Science 2025-11-21 Mohammad Areeb Qazi , Maryam Nadeem , Mohammad Yaqub