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The scarcity of high-quality multimodal biomedical data limits the ability to effectively fine-tune pretrained Large Language Models (LLMs) for specialized biomedical tasks. To address this challenge, we introduce MINT (Multimodal…

Quantitative Methods · Quantitative Biology 2026-02-18 Zhanliang Wang , Da Wu , Quan Nguyen , Zhuoran Xu , Kai Wang

Thanks to the emerging of foundation models, the large language and vision models are integrated to acquire the multimodal ability of visual captioning, question answering, etc. Although existing multimodal models present impressive…

Computer Vision and Pattern Recognition · Computer Science 2023-12-29 Bo Zhao , Boya Wu , Muyang He , Tiejun Huang

Instruction tuning is a crucial supervised training phase in Large Language Models (LLMs), aiming to enhance the LLM's ability to generalize instruction execution and adapt to user preferences. With the increasing integration of multi-modal…

Multimedia · Computer Science 2023-11-28 Chen Li , Yixiao Ge , Dian Li , Ying Shan

Pathological diagnosis remains the definitive standard for identifying tumors. The rise of multimodal large models has simplified the process of integrating image analysis with textual descriptions. Despite this advancement, the substantial…

Computer Vision and Pattern Recognition · Computer Science 2024-08-14 Xiaomin Wu , Rui Xu , Pengchen Wei , Wenkang Qin , Peixiang Huang , Ziheng Li , Lin Luo

Prompt learning is one of the most effective paradigms for adapting pre-trained vision-language models (VLMs) to the biomedical image classification tasks in few shot scenarios. However, most of the current prompt learning methods only used…

Computer Vision and Pattern Recognition · Computer Science 2025-05-09 Wei Peng , Kang Liu , Jianchen Hu , Meng Zhang

Multimodal pre-training demonstrates its potential in the medical domain, which learns medical visual representations from paired medical reports. However, many pre-training tasks require extra annotations from clinicians, and most of them…

Computer Vision and Pattern Recognition · Computer Science 2024-10-02 Tongkun Su , Jun Li , Xi Zhang , Haibo Jin , Hao Chen , Qiong Wang , Faqin Lv , Baoliang Zhao , Yin Hu

To enhance the performance of large language models (LLMs) in biomedical natural language processing (BioNLP) by introducing a domain-specific instruction dataset and examining its impact when combined with multi-task learning principles.…

Computation and Language · Computer Science 2024-06-10 Hieu Tran , Zhichao Yang , Zonghai Yao , Hong Yu

To advance biomedical vison-language model capabilities through scaling up, fine-tuning, and instruction tuning, develop vision-language models with improved performance in handling long text, explore strategies to efficiently adopt vision…

Artificial Intelligence · Computer Science 2025-05-26 Cheng Peng , Kai Zhang , Mengxian Lyu , Hongfang Liu , Lichao Sun , Yonghui Wu

Instruction tuning has shown promising potential for developing general-purpose AI capabilities by using large-scale pre-trained models and boosts growing research to integrate multimodal information for creative applications. However,…

Computation and Language · Computer Science 2023-12-21 Yihang Zhai , Haixin Wang , Jianlong Chang , Xinlong Yang , Jinan Sun , Shikun Zhang , Qi Tian

Visual instruction tuning (VIT) has emerged as a crucial technique for enabling multi-modal large language models (MLLMs) to follow user instructions adeptly. Yet, a significant gap persists in understanding the attributes of high-quality…

Computer Vision and Pattern Recognition · Computer Science 2025-04-01 Yiwei Ma , Guohai Xu , Xiaoshuai Sun , Jiayi Ji , Jie Lou , Debing Zhang , Rongrong Ji

Recent advancements in mixed-modal generative have opened new avenues for developing unified biomedical assistants capable of analyzing biomedical images, answering complex questions about them, and generating multimodal patient reports.…

Artificial Intelligence · Computer Science 2025-04-24 Hritik Bansal , Daniel Israel , Siyan Zhao , Shufan Li , Tung Nguyen , Aditya Grover

Traditional computer vision generally solves each single task independently by a dedicated model with the task instruction implicitly designed in the model architecture, arising two limitations: (1) it leads to task-specific models, which…

Computer Vision and Pattern Recognition · Computer Science 2023-12-29 Jiaxing Huang , Jingyi Zhang , Kai Jiang , Han Qiu , Shijian Lu

Large-scale Visual Instruction Tuning (VIT) has become a key paradigm for advancing the performance of vision-language models (VLMs) across various multimodal tasks. However, training on the large-scale datasets is computationally expensive…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Changti Wu , Jiahuai Mao , Yuzhuo Miao , Shijie Lian , Bin Yu , Xiaopeng Lin , Cong Huang , Lei Zhang , Kai Chen

Visual instruction tuning (VIT) for large vision-language models (LVLMs) requires training on expansive datasets of image-instruction pairs, which can be costly. Recent efforts in VIT data selection aim to select a small subset of…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Bardia Safaei , Faizan Siddiqui , Jiacong Xu , Vishal M. Patel , Shao-Yuan Lo

We present a novel visual instruction tuning strategy to improve the zero-shot task generalization of multimodal large language models by building a firm text-only knowledge base. Existing work lacks sufficient experimentation on the…

Computation and Language · Computer Science 2025-07-01 Jianhong Tu , Zhuohao Ni , Nicholas Crispino , Zihao Yu , Michael Bendersky , Beliz Gunel , Ruoxi Jia , Xin Liu , Lingjuan Lyu , Dawn Song , Chenguang Wang

Instruction following is crucial in contemporary LLM. However, when extended to multimodal setting, it often suffers from misalignment between specific textual instruction and targeted local region of an image. To achieve more accurate and…

Computer Vision and Pattern Recognition · Computer Science 2024-10-17 Jinliang Zheng , Jianxiong Li , Sijie Cheng , Yinan Zheng , Jiaming Li , Jihao Liu , Yu Liu , Jingjing Liu , Xianyuan Zhan

Understanding animal species from multimodal data poses an emerging challenge at the intersection of computer vision and ecology. While recent biological models, such as BioCLIP, have demonstrated strong alignment between images and textual…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Risa Shinoda , Kaede Shiohara , Nakamasa Inoue , Kuniaki Saito , Hiroaki Santo , Fumio Okura

Multimodal large language models are typically trained in two stages: first pre-training on image-text pairs, and then fine-tuning using supervised vision-language instruction data. Recent studies have shown that large language models can…

Machine Learning · Computer Science 2026-04-14 Lai Wei , Xiaozhe Li , Zihao Jiang , Weiran Huang , Lichao Sun

Many healthcare applications are inherently multimodal, involving several physiological signals. As sensors for these signals become more common, improving machine learning methods for multimodal healthcare data is crucial. Pretraining…

Machine Learning · Computer Science 2024-10-23 Ching Fang , Christopher Sandino , Behrooz Mahasseni , Juri Minxha , Hadi Pouransari , Erdrin Azemi , Ali Moin , Ellen Zippi

Recent advances in clinical AI have enabled remarkable progress across many clinical domains. However, existing benchmarks and models are primarily limited to a small set of modalities and tasks, which hinders the development of large-scale…

Machine Learning · Computer Science 2025-03-21 Wei Dai , Peilin Chen , Malinda Lu , Daniel Li , Haowen Wei , Hejie Cui , Paul Pu Liang
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