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State-of-the-art medical multi-modal LLMs (med-MLLMs), such as LLaVA-Med and BioMedGPT, primarily depend on scaling model size and data volume, with training driven largely by autoregressive objectives. However, we reveal that this approach…

Real-world clinical decision-making requires integrating heterogeneous data, including medical text, 2D images, 3D volumes, and videos, while existing AI systems fail to unify all these signals, limiting their utility. In this paper, we…

With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked significant interest in applying LLMs to…

Computation and Language · Computer Science 2023-11-06 Mingze Yuan , Peng Bao , Jiajia Yuan , Yunhao Shen , Zifan Chen , Yi Xie , Jie Zhao , Yang Chen , Li Zhang , Lin Shen , Bin Dong

Recent advances in large language models, particularly following GPT-4o, have sparked increasing interest in developing omni-modal models capable of understanding more modalities. While some open-source alternatives have emerged, there is…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Zuyan Liu , Yuhao Dong , Jiahui Wang , Ziwei Liu , Winston Hu , Jiwen Lu , Yongming Rao

Biomedical entity linking aims to map nonstandard entities to standard entities in a knowledge base. Traditional supervised methods perform well but require extensive annotated data to transfer, limiting their usage in low-resource…

Computation and Language · Computer Science 2025-05-27 Yihao Ai , Zhiyuan Ning , Weiwei Dai , Pengfei Wang , Yi Du , Wenjuan Cui , Kunpeng Liu , Yuanchun Zhou

As the latest advancements in natural language processing, large language models (LLMs) have achieved human-level language understanding and generation abilities in many real-world tasks, and even have been regarded as a potential path to…

This paper introduces a system that integrates large language models (LLMs) into the clinical trial retrieval process, enhancing the effectiveness of matching patients with eligible trials while maintaining information privacy and allowing…

Information Retrieval · Computer Science 2024-11-01 Georgios Peikos , Pranav Kasela , Gabriella Pasi

Multimodal Large Language Models (MLLMs) have demonstrated remarkable effectiveness in various general-domain scenarios, such as visual question answering and image captioning. Recently, researchers have increasingly focused on empowering…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Yan Shu , Chi Liu , Robin Chen , Derek Li , Bryan Dai

Large language models (LLMs) have rapidly advanced natural language processing, driving significant breakthroughs in tasks such as text generation, machine translation, and domain-specific reasoning. The field now faces a critical dilemma…

Computation and Language · Computer Science 2025-10-15 Jiya Manchanda , Laura Boettcher , Matheus Westphalen , Jasser Jasser

Large language models (LLMs) show promise for clinical use. They are often evaluated using datasets such as MedQA. However, Many medical datasets, such as MedQA, rely on simplified Question-Answering (Q\A) that underrepresents real-world…

Computation and Language · Computer Science 2025-10-24 Yunpeng Xiao , Carl Yang , Mark Mai , Xiao Hu , Kai Shu

We present a refined approach to biomedical question-answering (QA) services by integrating large language models (LLMs) with Multi-BERT configurations. By enhancing the ability to process and prioritize vast amounts of complex biomedical…

Computation and Language · Computer Science 2024-10-18 Cheng Qian , Xianglong Shi , Shanshan Yao , Yichen Liu , Fengming Zhou , Zishu Zhang , Junaid Akram , Ali Braytee , Ali Anaissi

Despite strong performance in medical question-answering, the clinical adoption of Large Language Models (LLMs) is critically hampered by their opaque 'black-box' reasoning, limiting clinician trust. This challenge is compounded by the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Chao Ding , Mouxiao Bian , Pengcheng Chen , Hongliang Zhang , Tianbin Li , Lihao Liu , Jiayuan Chen , Zhuoran Li , Yabei Zhong , Yongqi Liu , Haiqing Huang , Dongming Shan , Junjun He , Jie Xu

Evaluating natural language generation (NLG) systems in the medical domain presents unique challenges due to the critical demands for accuracy, relevance, and domain-specific expertise. Traditional automatic evaluation metrics, such as…

Computation and Language · Computer Science 2025-09-17 Wen-wai Yim , Asma Ben Abacha , Zixuan Yu , Robert Doerning , Fei Xia , Meliha Yetisgen

Instruction-finetuning (IFT) has become crucial in aligning Large Language Models (LLMs) with diverse human needs and has shown great potential in medical applications. However, previous studies mainly fine-tune LLMs on biomedical datasets…

Computation and Language · Computer Science 2025-04-02 Xinlu Zhang , Chenxin Tian , Xianjun Yang , Lichang Chen , Zekun Li , Linda Ruth Petzold

The development of open-source, multilingual medical language models can benefit a wide, linguistically diverse audience from different regions. To promote this domain, we present contributions from the following: First, we construct a…

Computation and Language · Computer Science 2024-06-04 Pengcheng Qiu , Chaoyi Wu , Xiaoman Zhang , Weixiong Lin , Haicheng Wang , Ya Zhang , Yanfeng Wang , Weidi Xie

Building high-quality data resources is crucial for advancing artificial intelligence research and applications in specific domains, particularly in the Chinese medical domain. Existing Chinese medical datasets are limited in size and…

Computation and Language · Computer Science 2025-07-22 Yuanhe Tian , Junjie Liu , Zhizhou Kou , Yuxiang Li , Yan Song

In the past year, there has been a growing trend in applying Large Language Models (LLMs) to the field of medicine, particularly with the advent of advanced language models such as ChatGPT developed by OpenAI. However, there is limited…

Computation and Language · Computer Science 2024-02-27 Fujian Jia , Xin Liu , Lixi Deng , Jiwen Gu , Chunchao Pu , Tunan Bai , Mengjiang Huang , Yuanzhi Lu , Kang Liu

Generative large language models (LLMs) have shown great success in various applications, including question-answering (QA) and dialogue systems. However, in specialized domains like traditional Chinese medical QA, these models may perform…

Computation and Language · Computer Science 2023-09-06 Yang Tan , Mingchen Li , Zijie Huang , Huiqun Yu , Guisheng Fan

The recently unprecedented advancements in Large Language Models (LLMs) have propelled the medical community by establishing advanced medical-domain models. However, due to the limited collection of medical datasets, there are only a few…

Computation and Language · Computer Science 2024-06-10 Ping Yu , Kaitao Song , Fengchen He , Ming Chen , Jianfeng Lu

Artificial intelligence has significantly advanced healthcare, particularly through large language models (LLMs) that excel in medical question answering benchmarks. However, their real-world clinical application remains limited due to the…

Computation and Language · Computer Science 2024-07-01 Zhihao Fan , Jialong Tang , Wei Chen , Siyuan Wang , Zhongyu Wei , Jun Xi , Fei Huang , Jingren Zhou