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The integrity of articular cartilage is a crucial aspect in the early diagnosis of osteoarthritis (OA). Many novel MRI techniques have the potential to assess compositional changes of the cartilage extracellular matrix. Among these…

Computer Vision and Pattern Recognition · Computer Science 2019-12-05 Alejandra Duarte , Chaitra V. Hegde , Aakash Kaku , Sreyas Mohan , José G. Raya

Reliable MRI is crucial for accurate interpretation in therapeutic and diagnostic tasks. However, undersampling during MRI acquisition as well as the overparameterized and non-transparent nature of deep learning (DL) leaves substantial…

Computer Vision and Pattern Recognition · Computer Science 2020-04-28 Vineet Edupuganti , Morteza Mardani , Shreyas Vasanawala , John Pauly

This article develops a new algorithm named TTRISK to solve high-dimensional risk-averse optimization problems governed by differential equations (ODEs and/or PDEs) under uncertainty. As an example, we focus on the so-called Conditional…

Numerical Analysis · Mathematics 2022-12-02 Harbir Antil , Sergey Dolgov , Akwum Onwunta

Objective: We evaluate a fully-automated femoral cartilage segmentation model for measuring T2 relaxation values and longitudinal changes using multi-echo spin echo (MESE) MRI. We have open sourced this model and corresponding…

Computer Vision and Pattern Recognition · Computer Science 2020-12-24 Kevin A. Thomas , Dominik Krzemiński , Łukasz Kidziński , Rohan Paul , Elka B. Rubin , Eni Halilaj , Marianne S. Black , Akshay Chaudhari , Garry E. Gold , Scott L. Delp

Objective assessment of Magnetic Resonance Imaging (MRI) scans of osteoarthritis (OA) can address the limitation of the current OA assessment. Segmentation of bone, cartilage, and joint fluid is necessary for the OA objective assessment.…

Image and Video Processing · Electrical Eng. & Systems 2022-06-27 Banafshe Felfeliyan , Abhilash Hareendranathan , Gregor Kuntze , Jacob L. Jaremko , Janet L. Ronsky

Osteosarcoma is the most common primary bone cancer whose standard treatment includes pre-operative chemotherapy followed by resection. Chemotherapy response is used for predicting prognosis and further management of patients. Necrosis is…

Time-resolved MR angiography (tMRA) has been widely used for dynamic contrast enhanced MRI (DCE-MRI) due to its highly accelerated acquisition. In tMRA, the periphery of the k-space data are sparsely sampled so that neighbouring frames can…

Image and Video Processing · Electrical Eng. & Systems 2020-03-31 Eunju Cha , Hyungjin Chung , Eung Yeop Kim , Jong Chul Ye

Bankart lesions, or anterior-inferior glenoid labral tears, are diagnostically challenging on standard MRIs due to their subtle imaging features-often necessitating invasive MRI arthrograms (MRAs). This study develops deep learning (DL)…

Computer Vision and Pattern Recognition · Computer Science 2025-04-09 Sahil Sethi , Sai Reddy , Mansi Sakarvadia , Jordan Serotte , Darlington Nwaudo , Nicholas Maassen , Lewis Shi

Acute kidney injury (AKI) commonly occurs in hospitalized patients and can lead to serious medical complications. In order to optimally predict AKI before it develops at any time during a hospital stay, we present a novel framework in which…

Quantitative Methods · Quantitative Biology 2019-02-28 Rohit J. Kate , Noah Pearce , Debesh Mazumdar , Vani Nilakantan

Alzheimer's disease (AD) is a devastating neurodegenerative condition that precedes progressive and irreversible dementia; thus, predicting its progression over time is vital for clinical diagnosis and treatment. Numerous studies have…

Artificial Intelligence · Computer Science 2023-10-06 Seungwoo Jeong , Wonsik Jung , Junghyo Sohn , Heung-Il Suk

Predicting clinical outcomes to anti-cancer drugs on a personalized basis is challenging in cancer treatment due to the heterogeneity of tumors. Traditional computational efforts have been made to model the effect of drug response on…

Machine Learning · Computer Science 2022-07-12 Jie Gao , Jing Hu , Wanqing Sun , Yili Shen , Xiaonan Zhang , Xiaomin Fang , Fan Wang , Guodong Zhao

This work proposes a novel end-to-end convolutional neural network (CNN) architecture to automatically quantify the severity of knee osteoarthritis (OA) using X-Ray images, which incorporates trainable attention modules acting as…

Image and Video Processing · Electrical Eng. & Systems 2019-08-26 Marc Górriz , Joseph Antony , Kevin McGuinness , Xavier Giró-i-Nieto , Noel E. O'Connor

The performance of the data-dependent neural tangent kernel (NTK; Jacot et al. (2018)) associated with a trained deep neural network (DNN) often matches or exceeds that of the full network. This implies that DNN training via gradient…

Machine Learning · Computer Science 2025-05-22 Johannes Schwab , Bryan Kelly , Semyon Malamud , Teng Andrea Xu

Osteoporosis is a common disease that increases fracture risk. Hip fractures, especially in elderly people, lead to increased morbidity, decreased quality of life and increased mortality. Being a silent disease before fracture, osteoporosis…

Computer Vision and Pattern Recognition · Computer Science 2022-10-07 Lars Schmarje , Stefan Reinhold , Timo Damm , Eric Orwoll , Claus-C. Glüer , Reinhard Koch

Irregularly measured time series are common in many of the applied settings in which time series modelling is a key statistical tool, including medicine. This provides challenges in model choice, often necessitating imputation or similar…

Knee injuries are frequent, varied and often require the patient to undergo intensive rehabilitation for several months. Treatment protocols usually contemplate some recurrent measurements in order to assess progress, such as goniometry.…

Computer Vision and Pattern Recognition · Computer Science 2018-07-20 João Bernardino , Luís Filipe Teixeira , Hugo Sereno Ferreira

Osteoarthritis (OA) is a highly prevalent degenerative joint disease, and the knee is the most commonly affected joint. Biomechanical factors, particularly forces exerted during walking, are often measured in modern studies of knee joint…

Objective: Machine learning algorithms are now widely used in predicting acute events for clinical applications. While most of such prediction applications are developed to predict the risk of a particular acute event at one hospital, few…

In sports analytics, an understanding of accurate on-field 3D knee joint moments (KJM) could provide an early warning system for athlete workload exposure and knee injury risk. Traditionally, this analysis has relied on captive laboratory…

Computer Vision and Pattern Recognition · Computer Science 2019-07-12 William R. Johnson , Ajmal Mian , David G. Lloyd , Jacqueline A. Alderson

Deep-learning techniques, particularly the transformer model, have shown great potential in enhancing the prediction performance of longitudinal health records. While previous methods have mainly focused on fixed-time risk prediction,…

Machine Learning · Computer Science 2024-05-03 Moshe Zisser , Dvir Aran