Related papers: Positive-Unlabelled Learning for identifying new c…

Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

The extraction of sequence patterns from a collection of functionally linked unlabeled DNA sequences is known as DNA motif discovery, and it is a key task in computational biology. Several deep learning-based techniques have recently been…

The goal of unbiased learning to rank (ULTR) is to leverage implicit user feedback for optimizing learning-to-rank systems. Among existing solutions, automatic ULTR algorithms that jointly learn user bias models (i.e., propensity models)…

Dynamic treatment regimes (DTRs) consist of a sequence of decision rules, one per stage of intervention, that finds effective treatments for individual patients according to patient information history. DTRs can be estimated from models…

We propose a meta-learning method for positive and unlabeled (PU) classification, which improves the performance of binary classifiers obtained from only PU data in unseen target tasks. PU learning is an important problem since PU data…

Supervised fine-tuning (SFT) has become a crucial step for aligning pretrained large language models (LLMs) using supervised datasets of input-output pairs. However, despite being supervised, SFT is inherently limited by its generative…

This work proposes `PET', a novel pessimistic reward fine-tuning method, to learn a pessimistic reward model robust against reward hacking in offline reinforcement learning from human feedback (RLHF). Traditional reward modeling techniques…

Many real-world applications have to tackle the Positive-Unlabeled (PU) learning problem, i.e., learning binary classifiers from a large amount of unlabeled data and a few labeled positive examples. While current state-of-the-art methods…

Deep neural networks (DNNs) achieve state-of-the-art results in a variety of domains. Unfortunately, DNNs are notorious for their non-interpretability, and thus limit their applicability in hypothesis-driven domains such as biology and…

In reinforcement learning (RL), temporal difference (TD) error is known to be related to the firing rate of dopamine neurons. It has been observed that each dopamine neuron does not behave uniformly, but each responds to the TD error in an…

Recent advances in dynamic treatment regimes (DTRs) facilitate the search for optimal treatments, which are tailored to individuals' specific needs and able to maximize their expected clinical benefits. However, existing algorithms relying…

Aligning generative diffusion models with human preferences via reinforcement learning (RL) is critical yet challenging. Most existing algorithms are often vulnerable to reward hacking, such as quality degradation, over-stylization, or…

Bias is a common problem inherent in recommender systems, which is entangled with users' preferences and poses a great challenge to unbiased learning. For debiasing tasks, the doubly robust (DR) method and its variants show superior…

With the prevalence of Diabetes, the Diabetes Mellitus Retinopathy (DR) is becoming a major health problem across the world. The long-term medical complications arising due to DR have a significant impact on the patient as well as the…

Food recommendation system has proven as an effective technology to provide guidance on dietary choices, and this is especially important for patients suffering from chronic diseases. Unlike other multimedia recommendations, such as books…

Diabetic Retinopathy (DR) is a significant cause of blindness globally, highlighting the urgent need for early detection and effective treatment. Recent advancements in Machine Learning (ML) techniques have shown promise in DR detection,…

With surge of available but unlabeled data, Positive Unlabeled (PU) learning is becoming a thriving challenge. This work deals with this demanding task for which recent GAN-based PU approaches have demonstrated promising results. Generative…

Reward models are crucial for aligning large language models (LLMs) with human values and intentions. Existing approaches follow either Generative (GRMs) or Discriminative (DRMs) paradigms, yet both suffer from limitations: GRMs typically…

Developing new drugs is laborious and costly, demanding extensive time investment. In this paper, we introduce a de-novo drug design strategy, which harnesses the capabilities of language models to devise targeted drugs for specific…

Reinforcement learning (RL) is pivotal for enhancing the reasoning capabilities of diffusion large language models (dLLMs). However, existing dLLM policy optimization methods suffer from two critical reliability bottlenecks: (1) reward…