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We consider saddle point problems which objective functions are the average of $n$ strongly convex-concave individual components. Recently, researchers exploit variance reduction methods to solve such problems and achieve linear-convergence…

Machine Learning · Computer Science 2019-09-17 Luo Luo , Cheng Chen , Yujun Li , Guangzeng Xie , Zhihua Zhang

Structure-based drug design (SBDD) aims to discover drug candidates by finding molecules (ligands) that bind tightly to a disease-related protein (targets), which is the primary approach to computer-aided drug discovery. Recently, applying…

Quantitative Methods · Quantitative Biology 2022-12-01 Tianfan Fu , Wenhao Gao , Connor W. Coley , Jimeng Sun

Retrieval-Augmented Generation (RAG) systems typically face constraints because of their inherent mechanism: a simple top-k semantic search [1]. The approach often leads to the incorporation of irrelevant or redundant information in the…

Computation and Language · Computer Science 2025-09-03 Andreas Ottem

Time series analysis has emerged as an important tool for improving patient diagnosis and management in healthcare applications. However, these applications commonly face two critical challenges: time misalignment and data sparsity.…

Machine Learning · Statistics 2025-09-25 Dohyun Ku , Catherine D. Chong , Visar Berisha , Todd J. Schwedt , Jing Li

Processing-in-memory (PIM) is a promising computing paradigm to tackle the "memory wall" challenge. However, PIM system-level benefits over traditional von Neumann architecture can be reduced when the memory array cannot fully store all the…

Hardware Architecture · Computer Science 2025-03-03 Peilin Chen , Xiaoxuan Yang

The present von Neumann computing paradigm involves a significant amount of information transfer between a central processing unit (CPU) and memory, with concomitant limitations in the actual execution speed. However, it has been recently…

Emerging Technologies · Computer Science 2014-07-03 Fabio Lorenzo Traversa , Fabrizio Bonani , Yuriy V. Pershin , Massimiliano Di Ventra

We return to the geometry optimization problem of Lennard-Jones clusters to analyze the performance dependence of "cut and splice" genetic algorithms (GAs) on the employed population size. We generally find that admixing twinning mutation…

Materials Science · Physics 2015-05-13 Vladimir A. Froltsov , Karsten Reuter

In this work, we present an extension of the genetic algorithm (GA) which exploits the supervised learning technique called active subspaces (AS) to evolve the individuals on a lower dimensional space. In many cases, GA requires in fact…

Numerical Analysis · Mathematics 2021-07-13 Nicola Demo , Marco Tezzele , Gianluigi Rozza

The optimization of structural parameters, such as mass(m), stiffness(k), and damping coefficient(c), is critical for designing efficient, resilient, and stable structures. Conventional numerical approaches, including Finite Element Method…

Neural and Evolutionary Computing · Computer Science 2026-02-24 Sagnik Mukherjee , Indrajit Barua

In this effort we introduce and analyze a novel reduced basis approach, used to construct an approximating subspace for a given set of data. Our technique, which we call the Natural Greedy Algorithm (NGA), is based on a recursive approach…

Functional Analysis · Mathematics 2019-11-05 Anton Dereventsov , Clayton Webster

Security Constraint Unit commitment (SCUC) is one of the significant challenges in operation of power grids which tries to regulate the status of the generation units (ON or OFF) and providing an efficient power dispatch within the grid.…

Neural and Evolutionary Computing · Computer Science 2018-06-22 Ali Yazdandoost , Peyman Khazaei , Rahim Kamali , Salar Saadatian

The MaxCut problem is a fundamental problem in Combinatorial Optimization, with significant implications across diverse domains such as logistics, network design, and statistical physics. The algorithm represents innovative approaches that…

Quantum Physics · Physics 2025-01-03 Paulo A. Viana , Fernando M. de Paula Neto

Genetic algorithms are highly effective optimization techniques for many computationally challenging problems, including combinatorial optimization tasks like portfolio optimization. Quantum computing has also shown potential in addressing…

Emerging Technologies · Computer Science 2025-04-28 Mohammad Kashfi Haghighi , Matthieu Fortin-Deschênes , Christophe Pere , Mickaël Camus

Genetic Algorithms (GA) are a powerful tool for stochastic optimisation and non-parametric symbolic regression, already widely used in cosmology. They are capable of reconstructing analytical functions directly from data points without…

Cosmology and Nongalactic Astrophysics · Physics 2026-02-16 Matteo Peronaci , Matteo Martinelli , Savvas Nesseris

In clinical practice, a segmentation network is often required to continually learn on a sequential data stream from multiple sites rather than a consolidated set, due to the storage cost and privacy restriction. However, during the…

Image and Video Processing · Electrical Eng. & Systems 2022-06-28 Jingyang Zhang , Peng Xue , Ran Gu , Yuning Gu , Mianxin Liu , Yongsheng Pan , Zhiming Cui , Jiawei Huang , Lei Ma , Dinggang Shen

While many optimization problems work with a fixed number of decision variables and thus a fixed-length representation of possible solutions, genetic programming (GP) works on variable-length representations. A naturally occurring problem…

Neural and Evolutionary Computing · Computer Science 2018-06-07 Benjamin Doerr , Timo Kötzing , J. A. Gregor Lagodzinski , Johannes Lengler

The application of genetic algorithms (GAs) to many optimization problems in organizations often results in good performance and high quality solutions. For successful and efficient use of GAs, it is not enough to simply apply simple GAs…

Neural and Evolutionary Computing · Computer Science 2008-12-18 Maroun Bercachi , Philippe Collard , Manuel Clergue , Sébastien Verel

Medical imaging is an essential tool for diagnosing and treating diseases. However, lacking medical images can lead to inaccurate diagnoses and ineffective treatments. Generative models offer a promising solution for addressing medical…

Image and Video Processing · Electrical Eng. & Systems 2024-01-02 M. AbdulRazek , G. Khoriba , M. Belal

In multiprocessor systems, one of the main factors of systems' performance is task scheduling. The well the task be distributed among the processors the well be the performance. Again finding the optimal solution of scheduling the tasks…

Distributed, Parallel, and Cluster Computing · Computer Science 2012-08-10 Probir Roy , Md. Mejbah Ul Alam , Nishita Das

Nonlinear constrained optimization problems are encountered in many scientific fields. To utilize the huge calculation power of current computers, many mathematic models are also rebuilt as optimization problems. Most of them have…

Optimization and Control · Mathematics 2011-10-03 Wei Zhang , Xudong Shi , Liwen Wang
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