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Today's systems are overwhelmingly designed to move data to computation. This design choice goes directly against at least three key trends in systems that cause performance, scalability and energy bottlenecks: (1) data access from memory…

Hardware Architecture · Computer Science 2019-03-12 Onur Mutlu , Saugata Ghose , Juan Gómez-Luna , Rachata Ausavarungnirun

Biological network alignment aims to identify similar regions between networks of different species. Existing methods compute node "similarities" to rapidly identify from possible alignments the "high-scoring" alignments with respect to the…

Molecular Networks · Quantitative Biology 2013-11-12 Vikram Saraph , Tijana Milenković

Retrieval-Augmented Generation (RAG) is sensitive to the vast hyperparameters of the retriever and generator, yet optimizing them using given queries is a challenging task due to the complex interactions and expensive evaluation costs.…

Machine Learning · Computer Science 2026-05-12 Pengzhou Chen , Tao Chen

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating external knowledge retrieval but faces challenges on edge devices due to high storage, energy, and latency demands. Computing-in-Memory (CIM) offers a…

Sorting is a fundamental operation in various applications and a traditional research topic in computer science. Improving the performance of sorting operations can have a significant impact on many application domains. For high-performance…

Hardware Architecture · Computer Science 2023-10-13 Amir Hossein Jalilvand , Faeze S. Banitaba , Seyedeh Newsha Estiri , Sercan Aygun , M. Hassan Najafi

Predicting the cheapest sample size for the optimal stratification in multivariate survey design is a problem in cases where the population frame is large. A solution exists that iteratively searches for the minimum sample size necessary to…

Methodology · Statistics 2018-06-18 Mervyn O'Luing , Steven Prestwich , S. Armagan Tarim

Gaussian Probability Path based Generative Models (GPPGMs) generate data by reversing a stochastic process that progressively corrupts samples with Gaussian noise. Despite state-of-the-art results in 3D molecular generation, their…

Machine Learning · Computer Science 2026-02-23 Jingxiang Qu , Wenhan Gao , Ruichen Xu , Yi Liu

Projects consist of interconnected dimensions such as objective, time, resource and environment. Use of these dimensions in a controlled way and their effective scheduling brings the project success. Project scheduling process includes…

Artificial Intelligence · Computer Science 2019-02-05 Muhammed Hanefi Calp , Muhammet Ali Akcayol

Generating molecules, both in a directed and undirected fashion, is a huge part of the drug discovery pipeline. Genetic algorithms (GAs) generate molecules by randomly modifying known molecules. In this paper we show that GAs are very…

Neural and Evolutionary Computing · Computer Science 2023-10-16 Austin Tripp , José Miguel Hernández-Lobato

Nigam et al. reported a genetic algorithm (GA) utilizing the SELFIES representation and also propose an adaptive, neural network-based penalty that is supposed to improve the diversity of the generated molecules. The main claims of the…

Machine Learning · Computer Science 2021-02-11 Kevin Maik Jablonka , Fergus Mcilwaine , Susana Garcia , Berend Smit , Brian Yoo

With the advance in genome sequencing technology, the lengths of deoxyribonucleic acid (DNA) sequencing results are rapidly increasing at lower prices than ever. However, the longer lengths come at the cost of a heavy computational burden…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-03-12 Seongyeon Park , Junguk Hong , Jaeyong Song , Hajin Kim , Youngsok Kim , Jinho Lee

We present MA-RAG, a Multi-Agent framework for Retrieval-Augmented Generation (RAG) that addresses the inherent ambiguities and reasoning challenges in complex information-seeking tasks. Unlike conventional RAG methods that rely on…

Computation and Language · Computer Science 2025-10-14 Thang Nguyen , Peter Chin , Yu-Wing Tai

Von Neumann architecture based computers isolate/physically separate computation and storage units i.e. data is shuttled between computation unit (processor) and memory unit to realize logic/ arithmetic and storage functions. This…

Emerging Technologies · Computer Science 2020-02-17 Sandeep Kaur Kingra , Vivek Parmar , Che-Chia Chang , Boris Hudec , Tuo-Hung Hou , Manan Suri

Second-order optimization methods, which leverage curvature information, offer faster and more stable convergence than first-order methods such as stochastic gradient descent (SGD) and Adam. However, their practical adoption is hindered by…

Emerging Technologies · Computer Science 2025-12-08 Saitao Zhang , Yubiao Luo , Shiqing Wang , Pushen Zuo , Yongxiang Li , Lunshuai Pan , Zheng Miao , Zhong Sun

The emergence of Retrieval-augmented generation (RAG) has alleviated the issues of outdated and hallucinatory content in the generation of large language models (LLMs), yet it still reveals numerous limitations. When a general-purpose LLM…

Computation and Language · Computer Science 2024-12-20 Jiayi Wu , Hengyi Cai , Lingyong Yan , Hao Sun , Xiang Li , Shuaiqiang Wang , Dawei Yin , Ming Gao

Retrieval-augmented generation (RAG) techniques have proven to be effective in integrating up-to-date information, mitigating hallucinations, and enhancing response quality, particularly in specialized domains. While many RAG approaches…

Neural networks (NNs) are growing in importance and complexity. A neural network's performance (and energy efficiency) can be bound either by computation or memory resources. The processing-in-memory (PIM) paradigm, where computation is…

Hardware Architecture · Computer Science 2023-03-28 Geraldo F. Oliveira , Juan Gómez-Luna , Saugata Ghose , Amirali Boroumand , Onur Mutlu

The emergence of Next Generation Sequencing (NGS) platforms has increased the throughput of genomic sequencing and in turn the amount of data that needs to be processed, requiring highly efficient computation for its analysis. In this…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-12-12 Nicola Cadenelli , Jorda Polo , David Carrera

In information retrieval research; Genetic Algorithms (GA) can be used to find global solutions in many difficult problems. This study used different similarity measures (Dice, Inner Product) in the VSM, for each similarity measure we…

Information Retrieval · Computer Science 2013-12-03 Eman Al Mashagba , Feras Al Mashagba , Mohammad Othman Nassar

Nowadays, the major challenge in machine learning is the Big Data challenge. The big data problems due to large number of data points or large number of features in each data point, or both, the training of models have become very slow. The…

Machine Learning · Computer Science 2018-07-26 Vinod Kumar Chauhan , Anuj Sharma , Kalpana Dahiya
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