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Continuous glucose monitoring (CGM) is vital for diabetes care, but current systems rely on invasive implants or electrochemical sensors that often cause discomfort and skin irritation. Non-invasive alternatives remain limited by low…

Accurately detecting hypoglycemia without invasive glucose sensors remains a critical challenge in diabetes management, particularly in regions where continuous glucose monitoring (CGM) is prohibitively expensive or clinically inaccessible.…

Human-Computer Interaction · Computer Science 2026-02-12 Lawrence Obiuwevwi , Krzysztof J. Rechowicz , Vikas Ashok , Sampath Jayarathna

Several centimeters below the skin lie multiple biomarkers, such as glucose, oxygenation, and blood flow. Monitoring these biomarkers regularly and in a non-invasive manner would enable early insight into metabolic status and vascular…

Medical Physics · Physics 2025-10-30 Talia Xu , Caitlin Smith , Charles Lo , Jami Shepherd , Gijs van Soest , Marco Zuniga

The classification of diabetes and prediabetes by static glucose thresholds obscures the pathophysiological dysglycemia heterogeneity, primarily driven by insulin resistance (IR), beta-cell dysfunction, and incretin deficiency. This review…

Machine Learning · Computer Science 2025-11-07 Ahmed A. Metwally , Heyjun Park , Yue Wu , Tracey McLaughlin , Michael P. Snyder

In the U.S., over a third of adults are pre-diabetic, with 80\% unaware of their status. This underlines the need for better glucose monitoring to prevent type 2 diabetes and related heart diseases. Existing wearable glucose monitors are…

Signal Processing · Electrical Eng. & Systems 2024-06-26 Yidong Zhu , Nadia B Aimandi , Mohammad Arif Ul Alam

Continuous Blood Glucose (CGM) monitors have revolutionized the ability of diabetics to manage their blood glucose, and paved the way for artificial pancreas systems. In this paper we augment CGM data with sensor input collected by a smart…

Human-Computer Interaction · Computer Science 2023-02-06 Sam Royston

An algorithm based on PLS regression has been developed and optimized for measuring blood glucose level using the infra-red transmission spectrum of blood samples. A set of blood samples were tagged with their glucose concentration using an…

Quantitative Methods · Quantitative Biology 2018-04-11 Afarin Aghassizadeh , Mohammad Reza Nematollahi , Iman Mirzaie , Mehdi Fardmanesh

Biosensor data has the potential ability to improve disease control and detection. However, the analysis of these data under free-living conditions is not feasible with current statistical techniques. To address this challenge, we introduce…

Applications · Statistics 2021-03-30 Marcos Matabuena , Alexander Petersen , Juan C. Vidal , Francisco Gude

The rising rates of diabetes necessitate innovative methods for its management. Continuous glucose monitors (CGM) are small medical devices that measure blood glucose levels at regular intervals providing insights into daily patterns of…

Quantitative Methods · Quantitative Biology 2024-10-10 Renat Sergazinov , Elizabeth Chun , Valeriya Rogovchenko , Nathaniel Fernandes , Nicholas Kasman , Irina Gaynanova

Diabetes mellitus is a growing global health issue, with Type 1 Diabetes (T1D) requiring constant monitoring to avoid hypoglycemia. Although Continuous Glucose Monitors (CGMs) are effective, their cost and invasiveness limit access,…

Human-Computer Interaction · Computer Science 2025-09-23 Lawrence Obiuwevwi , Krzysztof J. Rechowicz , Vikas Ashok , Sampath Jayarathna

Diabetes is a prevalent chronic condition that compromises the health of millions of people worldwide. Minimally invasive methods are needed to prevent and control diabetes but most devices for measuring glucose levels are invasive and not…

In the case of diabetes, fingertip pricking for a blood sample is inconvenient for glucose measurement. Invasive approaches like laboratory test and one-touch glucometer enhance the risk of blood-related infections. To mitigate this…

Signal Processing · Electrical Eng. & Systems 2021-06-28 Prateek Jain , Amit M. Joshi , Saraju P. Mohanty

Diabetes encompasses a complex landscape of glycemic control that varies widely among individuals. However, current methods do not faithfully capture this variability at the meal level. On the one hand, expert-crafted features lack the…

Machine Learning · Computer Science 2023-12-07 Ke Alexander Wang , Emily B. Fox

Sustained high levels of blood glucose in type 2 diabetes (T2DM) can have disastrous long-term health consequences. An essential component of clinical interventions for T2DM is monitoring dietary intake to keep plasma glucose levels within…

Quantitative Methods · Quantitative Biology 2022-06-24 Zepeng Huo , Bobak J. Mortazavi , Theodora Chaspari , Nicolaas Deutz , Laura Ruebush , Ricardo Gutierrez-Osuna

A novel mediator-free, non-enzymatic electrochemical sensor, based on a graphene-Schottky junction, was fabricated for glucose detection. The sensor offers a promising alternative to the conventional enzyme-catalyzed electrochemical…

Chemical Physics · Physics 2015-09-09 Mohamed Serry , M. A. Sakr

Understanding how biomarker distributions evolve over time is a central challenge in digital health and chronic disease monitoring. In diabetes, changes in the distribution of glucose measurements can reveal patterns of disease progression…

Machine Learning · Statistics 2026-03-26 Antonio Álvarez-López , Marcos Matabuena

Continuous glucose monitoring (CGM) data has revolutionized the management of type 1 diabetes, particularly when integrated with insulin pumps to mitigate clinical events such as hypoglycemia. Recently, there has been growing interest in…

The challenge of handling missing data is widespread in modern data analysis, particularly during the preprocessing phase and in various inferential modeling tasks. Although numerous algorithms exist for imputing missing data, the…

Methodology · Statistics 2024-03-28 Marcos Matabuena , Carla Díaz-Louzao , Rahul Ghosal , Francisco Gude

There has been a recent tremendous interest in label-free detection of biomarkers which is a critical enabler of point-of-need diagnostics. A low-power, small form factor, multiplexed wearable system is proposed for continuous detection of…

Signal Processing · Electrical Eng. & Systems 2021-04-06 Devangsingh Sankhala , Madhavi Pali , Kai-Chun Lin , Badrinath Jagannath , Sriram Muthukumar , Shalini Prasad

Fluorescence lifetime imaging (FLI) is a widely used technique in the biomedical field for measuring the decay times of fluorescent molecules, providing insights into metabolic states, protein interactions, and ligand-receptor bindings.…

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