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Single-cell data analysis has the potential to revolutionize personalized medicine by characterizing disease-associated molecular changes at the single-cell level. Advanced single-cell multimodal assays can now simultaneously measure…
Instance segmentation enables the analysis of spatial and temporal properties of cells in microscopy images by identifying the pixels belonging to each cell. However, progress is constrained by the scarcity of high-quality labeled…
Learning disentangled representations is a fundamental task in multi-modal learning. In modern applications such as single-cell multi-omics, both shared and modality-specific features are critical for characterizing cell states and…
In the application of machine learning to remote sensing, labeled data is often scarce or expensive, which impedes the training of powerful models like deep convolutional neural networks. Although unlabeled data is abundant, recent…
In this paper we propose a unified framework to simultaneously discover the number of clusters and group the data points into them using subspace clustering. Real data distributed in a high-dimensional space can be disentangled into a union…
In systems biomedicine, an experimenter encounters different potential sources of variation in data such as individual samples, multiple experimental conditions, and multi-variable network-level responses. In multiparametric cytometry,…
Patients with the COVID-19 infection may have pneumonia-like symptoms as well as respiratory problems which may harm the lungs. From medical images, coronavirus illness may be accurately identified and predicted using a variety of machine…
Often, applications of self-supervised learning to 3D medical data opt to use 3D variants of successful 2D network architectures. Although promising approaches, they are significantly more computationally demanding to train, and thus reduce…
We propose a novel method for unsupervised semantic image segmentation based on mutual information maximization between local and global high-level image features. The core idea of our work is to leverage recent progress in self-supervised…
Swift and accurate blood smear analysis is an effective diagnostic method for leukemia and other hematological malignancies. However, manual leukocyte count and morphological evaluation using a microscope is time-consuming and prone to…
Temporal data, obtained in the setting where it is only possible to observe one time point per experiment, is widely used in different research fields, yet remains insufficiently addressed from the statistical point of view. Such data often…
Computed Tomography (CT) scans provide a detailed image of the lungs, allowing clinicians to observe the extent of damage caused by COVID-19. The CT severity score (CTSS) based scoring method is used to identify the extent of lung…
Recent technological advances have made it possible to collect high-dimensional genomic data along with clinical data on a large number of subjects. In the studies of chronic diseases such as cancer, it is of great interest to integrate…
Implicit Neural Representations (INRs) are widely used to encode data as continuous functions, enabling the visualization of large-scale multivariate scientific simulation data with reduced memory usage. However, existing INR-based methods…
Covariate adjustment aims to improve the statistical efficiency of randomized trials by incorporating information from baseline covariates. Popular methods for covariate adjustment include analysis of covariance for continuous endpoints and…
In this study, we introduce a multi-modal approach that efficiently integrates multi-scale clinical and dermoscopy features within a single network, thereby substantially reducing model parameters. The proposed method includes three novel…
Electronic Health Records have become popular sources of data for secondary research, but their use is hampered by the amount of effort it takes to overcome the sparsity, irregularity, and noise that they contain. Modern learning…
Healthcare datasets obtained from Electronic Health Records have proven to be extremely useful to assess associations between patients' predictors and outcomes of interest. However, these datasets often suffer from missing values in a high…
Counterfactual estimation over time is important in various applications, such as personalized medicine. However, time-dependent confounding bias in observational data still poses a significant challenge in achieving accurate and efficient…
While self-supervised learning techniques are often used to mining implicit knowledge from unlabeled data via modeling multiple views, it is unclear how to perform effective representation learning in a complex and inconsistent context. To…