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Establishing causality is a fundamental goal in fields like medicine and social sciences. While randomized controlled trials are the gold standard for causal inference, they are not always feasible or ethical. Observational studies can…
Clinical randomized controlled trials (RCTs) collect hundreds of measurements spanning various metric types (e.g., laboratory tests, cognitive/motor assessments, etc.) across 100s-1000s of subjects to evaluate the effect of a treatment, but…
Inspired by the success of reinforcement learning (RL) in Large Language Model (LLM) training for domains like math and code, recent works have begun exploring how to train LLMs to use search engines more effectively as tools for…
Medical treatments often involve a sequence of decisions, each informed by previous outcomes. This process closely aligns with reinforcement learning (RL), a framework for optimizing sequential decisions to maximize cumulative rewards under…
Randomized controlled trials (RCTs) can be used to generate guarantees on treatment effects. However, RCTs often spend unnecessary resources exploring sub-optimal treatments, which can reduce the power of treatment guarantees. To address…
Digital Adherence Technologies (DATs) are an increasingly popular method for verifying patient adherence to many medications. We analyze data from one city served by 99DOTS, a phone-call-based DAT deployed for Tuberculosis (TB) treatment in…
Deep neural networks (DNNs) fail to learn effectively under label noise and have been shown to memorize random labels which affect their generalization performance. We consider learning in isolation, using one-hot encoded labels as the sole…
Reinforcement learning with verifiable rewards (RLVR) has become a key technique for en- hancing LLM reasoning, yet its data ineffi- ciency remains a major bottleneck. Existing methods address this problem only partially, each missing at…
Background: Clinical diagnosis is typically reached by following a series of steps recommended by guidelines authored by colleges of experts. Accordingly, guidelines play a crucial role in rationalizing clinical decisions but suffer from…
The integration of real-world data (RWD) and randomized controlled trials (RCT) is increasingly important for advancing causal inference in scientific research. This combination holds great promise for enhancing the efficiency of causal…
Several high-resource Text to Speech (TTS) systems currently produce natural, well-established human-like speech. In contrast, low-resource languages, including Arabic, have very limited TTS systems due to the lack of resources. We propose…
Leveraging external controls -- relevant individual patient data under control from external trials or real-world data -- has the potential to reduce the cost of randomized controlled trials (RCTs) while increasing the proportion of trial…
Randomized smoothing (RS) has successfully been used to improve the robustness of predictions for deep neural networks (DNNs) by adding random noise to create multiple variations of an input, followed by deciding the consensus. To…
In the realm of Intelligent Tutoring System (ITS), the accurate assessment of students' knowledge states through Knowledge Tracing (KT) is crucial for personalized learning. However, due to data bias, $\textit{i.e.}$, the unbalanced…
Randomized clinical trials (RCTs) are widely considered the gold standard for evaluating the effectiveness of new treatments or interventions in drug development. Still, they may not be feasible in certain cases, such as with rare diseases…
In this paper we present tools for applied researchers that re-purpose off-the-shelf methods from the computer-science field of machine learning to create a "discovery engine" for data from randomized controlled trials (RCTs). The applied…
Offline reinforcement learning has shown promise for solving tasks in safety-critical settings, such as clinical decision support. Its application, however, has been limited by the lack of interpretability and interactivity for clinicians.…
Covariate adjustment is widely recommended to improve statistical efficiency in randomized clinical trials (RCTs), yet empirical evidence comparing available strategies remains limited. This lack of real-world evaluation leaves unresolved…
Studies on semi-supervised medical image segmentation (SSMIS) have seen fast progress recently. Due to the limited labelled data, SSMIS methods mainly focus on effectively leveraging unlabeled data to enhance the segmentation performance.…
A core component of precision medicine research involves optimizing individualized treatment rules (ITRs) based on patient characteristics. Many studies used to estimate ITRs are longitudinal in nature, collecting outcomes over time. Yet,…