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We utilize the externally forced linearized Navier-Stokes equations to study the receptivity of pre-transitional boundary layers to persistent sources of stochastic excitation. Stochastic forcing is used to model the effect of free-stream…
Deviation of blood flow from an optimal range is known to be associated with the initiation and progression of vascular pathologies. Important open questions remain about how the abnormal flow drives specific wall changes in pathologies…
Ischemic stroke, caused by cerebral vessel occlusion, presents substantial challenges in medical imaging due to the variability and subtlety of stroke lesions. Magnetic Resonance Imaging (MRI) plays a crucial role in diagnosing and managing…
Dynamic susceptibility-weighted contrast-enhanced (DSC) MRI or perfusion-MRI plays an important role in the non-invasive assessment of tumor vascularity. However, the large number of images provided by the method makes display and…
Stroke is the second most common cause of death in developed countries, where rapid clinical intervention can have a major impact on a patient's life. To perform the revascularization procedure, the decision making of physicians considers…
Perfusion-weighted magnetic resonance imaging (MRI) is an imaging technique that allows one to measure tissue perfusion in an organ of interest through the injection of an intravascular paramagnetic contrast agent (CA). Due to a preference…
Brain parenchymal fraction (BPF) has been used as a surrogate measure of global brain atrophy, and as a biomarker of brain reserve in studies evaluating clinical outcomes after brain injury. Total brain volume at the time of injury has…
The Thrombolysis in Cerebral Infarction (TICI) score is an important metric for reperfusion therapy assessment in acute ischemic stroke. It is commonly used as a technical outcome measure after endovascular treatment (EVT). Existing TICI…
Computed tomography perfusion (CTP) at admission is routinely used to estimate the ischemic core and penumbra, while follow-up diffusion-weighted MRI (DWI) provides the definitive infarct outcome. However, single time-point segmentations…
The impulse response function (IRF) of a localized bolus in cerebral blood flow codes important information on the tissue type. It is indirectly accessible both from MR- and CT-imaging methods, at least in principle. In practice, however,…
Background and Objective: This proof of concept study investigates mathematical modelling of blood flow and oxygen transport in cerebral microcirculation, focusing on understanding hemodynamic responses. By coupling oxygen transport models…
Purpose: Multi-expert deep learning training methods to automatically quantify ischemic brain tissue on Non-Contrast CT Materials and Methods: The data set consisted of 260 Non-Contrast CTs from 233 patients of acute ischemic stroke…
Stroke is the second leading cause of mortality worldwide. Immediate attention and diagnosis play a crucial role regarding patient prognosis. The key to diagnosis consists in localizing and delineating brain lesions. Standard stroke…
Arterial Spin Labelling (ASL) functional Magnetic Resonance Imaging (fMRI) data provides a quantitative measure of blood perfusion, that can be correlated to neuronal activation. In contrast to BOLD measure, it is a direct measure of…
Perfusion imaging is extensively utilized to assess hemodynamic status and tissue perfusion in various organs. Computed tomography perfusion (CTP) imaging plays a key role in the early assessment and planning of stroke treatment. While CTP…
Cardiac CT is often used clinically in electrophysiology to evaluate cardiac morphology. One such case is to evaluate patients with Atrial Fibrillation (AF). AF can cause regions of slow blood flow and blood stasis through the left atrial…
This study compares baseline (J0) and 24-hour (J1) diffusion magnetic resonance imaging (MRI) for predicting three-month functional outcomes after acute ischemic stroke (AIS). Seventy-four AIS patients with paired apparent diffusion…
CT Perfusion (CTP) imaging has gained importance in the diagnosis of acute stroke. Conventional perfusion analysis performs a deconvolution of the measurements and thresholds the perfusion parameters to determine the tissue status. We…
Background Atrial fibrillation is often missed by traditional intermittent electrocardiogram monitoring after ischemic stroke due to its paroxysmal and asymptomatic nature. The knowledge of the unique characteristics of the population with…
Stroke poses a significant global health threat, with millions affected annually, leading to substantial morbidity and mortality. Current stroke risk assessment for the general population relies on markers such as demographics, blood tests,…