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We utilize the externally forced linearized Navier-Stokes equations to study the receptivity of pre-transitional boundary layers to persistent sources of stochastic excitation. Stochastic forcing is used to model the effect of free-stream…

Fluid Dynamics · Physics 2019-09-09 Wei Ran , Armin Zare , M. J. Philipp Hack , Mihailo R. Jovanović

Deviation of blood flow from an optimal range is known to be associated with the initiation and progression of vascular pathologies. Important open questions remain about how the abnormal flow drives specific wall changes in pathologies…

Ischemic stroke, caused by cerebral vessel occlusion, presents substantial challenges in medical imaging due to the variability and subtlety of stroke lesions. Magnetic Resonance Imaging (MRI) plays a crucial role in diagnosing and managing…

Image and Video Processing · Electrical Eng. & Systems 2025-01-07 Ashiqur Rahman , Muhammad E. H. Chowdhury , Md Sharjis Ibne Wadud , Rusab Sarmun , Adam Mushtak , Sohaib Bassam Zoghoul , Israa Al-Hashimi

Dynamic susceptibility-weighted contrast-enhanced (DSC) MRI or perfusion-MRI plays an important role in the non-invasive assessment of tumor vascularity. However, the large number of images provided by the method makes display and…

General Physics · Physics 2007-11-20 Friso Hoefnagels , Keith S Cover , Ester Sanchez , Frank J. Lagerwaard

Stroke is the second most common cause of death in developed countries, where rapid clinical intervention can have a major impact on a patient's life. To perform the revascularization procedure, the decision making of physicians considers…

Computer Vision and Pattern Recognition · Computer Science 2018-09-25 Adriano Pinto , Sergio Pereira , Raphael Meier , Victor Alves , Roland Wiest , Carlos A. Silva , Mauricio Reyes

Perfusion-weighted magnetic resonance imaging (MRI) is an imaging technique that allows one to measure tissue perfusion in an organ of interest through the injection of an intravascular paramagnetic contrast agent (CA). Due to a preference…

Computer Vision and Pattern Recognition · Computer Science 2017-08-28 Cagdas Ulas , Christine Preibisch , Jonathan Sperl , Thomas Pyka , Jayashree Kalpathy-Cramer , Bjoern Menze

Brain parenchymal fraction (BPF) has been used as a surrogate measure of global brain atrophy, and as a biomarker of brain reserve in studies evaluating clinical outcomes after brain injury. Total brain volume at the time of injury has…

Neurons and Cognition · Quantitative Biology 2024-03-20 Kenda Alhadid , Robert W. Regenhardt , Natalia S. Rost , Markus D. Schirmer

The Thrombolysis in Cerebral Infarction (TICI) score is an important metric for reperfusion therapy assessment in acute ischemic stroke. It is commonly used as a technical outcome measure after endovascular treatment (EVT). Existing TICI…

Computed tomography perfusion (CTP) at admission is routinely used to estimate the ischemic core and penumbra, while follow-up diffusion-weighted MRI (DWI) provides the definitive infarct outcome. However, single time-point segmentations…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Md Sazidur Rahman , Kjersti Engan , Kathinka Dæhli Kurz , Mahdieh Khanmohammadi

The impulse response function (IRF) of a localized bolus in cerebral blood flow codes important information on the tissue type. It is indirectly accessible both from MR- and CT-imaging methods, at least in principle. In practice, however,…

Tissues and Organs · Quantitative Biology 2014-09-30 Evelyn Rost , Ralf Geske , Michael Baake

Background and Objective: This proof of concept study investigates mathematical modelling of blood flow and oxygen transport in cerebral microcirculation, focusing on understanding hemodynamic responses. By coupling oxygen transport models…

Numerical Analysis · Mathematics 2024-11-19 Maryam Samavaki , Santtu Söderholm , Arash Zarrin Nia , Sampsa Pursiainen

Purpose: Multi-expert deep learning training methods to automatically quantify ischemic brain tissue on Non-Contrast CT Materials and Methods: The data set consisted of 260 Non-Contrast CTs from 233 patients of acute ischemic stroke…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Sophie Ostmeier , Brian Axelrod , Benjamin Pulli , Benjamin F. J. Verhaaren , Abdelkader Mahammedi , Yongkai Liu , Christian Federau , Greg Zaharchuk , Jeremy J. Heit

Stroke is the second leading cause of mortality worldwide. Immediate attention and diagnosis play a crucial role regarding patient prognosis. The key to diagnosis consists in localizing and delineating brain lesions. Standard stroke…

Image and Video Processing · Electrical Eng. & Systems 2024-09-05 Santiago Gómez , Daniel Mantilla , Gustavo Garzón , Edgar Rangel , Andrés Ortiz , Franklin Sierra-Jerez , Fabio Martínez

Arterial Spin Labelling (ASL) functional Magnetic Resonance Imaging (fMRI) data provides a quantitative measure of blood perfusion, that can be correlated to neuronal activation. In contrast to BOLD measure, it is a direct measure of…

Applications · Statistics 2015-01-07 Aina Frau-Pascual , Thomas Vincent , Jennifer Sloboda , Philippe CIUCIU , Florence Forbes

Perfusion imaging is extensively utilized to assess hemodynamic status and tissue perfusion in various organs. Computed tomography perfusion (CTP) imaging plays a key role in the early assessment and planning of stroke treatment. While CTP…

Cardiac CT is often used clinically in electrophysiology to evaluate cardiac morphology. One such case is to evaluate patients with Atrial Fibrillation (AF). AF can cause regions of slow blood flow and blood stasis through the left atrial…

Image and Video Processing · Electrical Eng. & Systems 2025-02-06 Lauren M. Severance , Andrew M. Kahn , Juan C. del Alamo , Elliot R. McVeigh

This study compares baseline (J0) and 24-hour (J1) diffusion magnetic resonance imaging (MRI) for predicting three-month functional outcomes after acute ischemic stroke (AIS). Seventy-four AIS patients with paired apparent diffusion…

Image and Video Processing · Electrical Eng. & Systems 2025-12-03 Sina Raeisadigh , Myles Joshua Toledo Tan , Henning Müller , Abderrahmane Hedjoudje

CT Perfusion (CTP) imaging has gained importance in the diagnosis of acute stroke. Conventional perfusion analysis performs a deconvolution of the measurements and thresholds the perfusion parameters to determine the tissue status. We…

Background Atrial fibrillation is often missed by traditional intermittent electrocardiogram monitoring after ischemic stroke due to its paroxysmal and asymptomatic nature. The knowledge of the unique characteristics of the population with…

Neurons and Cognition · Quantitative Biology 2023-05-25 Yiming Chen , Sihui Wang , Dong Xu

Stroke poses a significant global health threat, with millions affected annually, leading to substantial morbidity and mortality. Current stroke risk assessment for the general population relies on markers such as demographics, blood tests,…

Image and Video Processing · Electrical Eng. & Systems 2024-07-24 Yu Xi Huang , Simon Mahler , Aidin Abedi , Julian Michael Tyszka , Yu Tung Lo , Patrick D. Lyden , Jonathan Russin , Charles Liu , Changhuei Yang