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Late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR) can directly visualize nonviable myocardium with hyperenhanced intensities with respect to normal myocardium. For heart attack patients, it is crucial to facilitate the…
We characterized the dosimetric properties of a clinical linear accelerator configured to deliver ultra-high dose rate (UHDR) irradiation to mice and cell-culture FLASH radiobiology experiments. UHDR electron beams were controlled by a…
The purpose of this study is to present and compare three denoising diffusion probabilistic models (DDPMs) that generate 3D $T_1$-weighted MRI human brain images. Three DDPMs were trained using 80,675 image volumes from 42,406 subjects…
In this paper, we propose a system to detect brain tumor in 3D MRI brain scans of Flair modality. It performs 2 functions: (a) predicting gray-level and locational distributions of the pixels in the tumor regions and (b) generating tumor…
Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), a new imaging method…
In the medical field, landmark detection in MRI plays an important role in reducing medical technician efforts in tasks like scan planning, image registration, etc. First, 88 landmarks spread across the brain anatomy in the three respective…
Latent diffusion models (LDMs) have recently achieved strong performance in 3D medical image synthesis. However, modalities like cine cardiac MRI (CMR), representing a temporally synchronized 3D volume across the cardiac cycle, add an…
Transcranial focused ultrasound (FUS) is a non-invasive technique for therapy and study of brain neural activation. Here we report on the design and characterization of a new MR-guided FUS transducer for neuromodulation in non-human…
Imaging the brain vasculature can be critical for cerebral perfusion monitoring in the context of neurocritical care. Although ultrasensitive Doppler (UD) can provide good sensitivity to cerebral blood volume (CBV) in a large field of view,…
Alzheimer's disease (AD), characterized by progressive cognitive decline and memory loss, presents a formidable global health challenge, underscoring the critical importance of early and precise diagnosis for timely interventions and…
Coronary microvascular disease constitutes a substantial risk to human health. Employing computer-aided analysis and diagnostic systems, medical professionals can intervene early in disease progression, with 3D vessel segmentation serving…
Volumetric, multimodal imaging with precise spatial and temporal co-registration can provide valuable and complementary information for diagnosis and monitoring. Considerable research has sought to combine 3D photoacoustic (PA) and…
Super-resolution ultrasound imaging (SRUS) is an active area of research as it brings up to a ten-fold improvement in the resolution of microvascular structures. The limitations to the clinical adoption of SRUS include long acquisition…
Chest radiographs are used for the diagnosis of multiple critical illnesses (e.g., Pneumonia, heart failure, lung cancer), for this reason, systems for the automatic or semi-automatic analysis of these data are of particular interest. An…
Harmonizing the analysis of data, especially of 3-D image volumes, consisting of different number of slices and annotated per volume, is a significant problem in training and using deep neural networks in various applications, including…
High-resolution (HR) MRI scans obtained from research-grade medical centers provide precise information about imaged tissues. However, routine clinical MRI scans are typically in low-resolution (LR) and vary greatly in contrast and spatial…
Deep learning-based super-resolution (SR) techniques have generally achieved excellent performance in the computer vision field. Recently, it has been proven that three-dimensional (3D) SR for medical volumetric data delivers better visual…
The increasing interest in FLASH-RT has lead to the conversion of linear accelerators to enable ultra-high dose rate (UHDR) beams for preclinical research. Dosimetry hereof remains challenging with several crucial aspects missing. This work…
Accurate assessment of intraventricular blood flow is essential for evaluating hemodynamic conditions in patients supported by Left Ventricular Assist Devices (LVADs). However, clinical imaging is either incompatible with LVADs or yields…
Due to the inter- and intra- variation of respiratory motion, it is highly desired to provide real-time volumetric images during the treatment delivery of lung stereotactic body radiation therapy (SBRT) for accurate and active motion…