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Purpose: To develop the first 3D optic nerve head (ONH) atlas using AI-based registration and evaluate its use in: (1) atlas-adjusted retinal nerve fiber layer (RNFL) analysis for glaucoma diagnosis, and (2) strain-based assessment of…

Speckle noise and retinal shadows within OCT B-scans occlude important edges, fine textures and deep tissues, preventing accurate and robust diagnosis by algorithms and clinicians. We developed a single process that successfully removed…

Polarized neutron reflectometry (PNR) have developed theoretically and experimentally in the past decades. In order to resolve the phase problem in neutron reflectometry, several simulation methods have been proposed such as reference layer…

Recently, the generalization behavior of Convolutional Neural Networks (CNN) is gradually transparent through explanation techniques with the frequency components decomposition. However, the importance of the phase spectrum of the image for…

Chromatic dispersion is a common problem to degrade the system resolution in optical coherence tomography (OCT). This study is to develop a deep learning network for automated dispersion compensation (ADC-Net) in OCT. The ADC-Net is based…

In long adaptive optics corrected exposures, exoplanet detections are currently limited by speckle noise originating from the telescope and instrument optics, and it is expected that such noise will also limit future high-contrast imaging…

The Henle's fiber layer (HFL) in the retina carries valuable information on the macular condition of an eye. However, in the common practice, this layer is not separately segmented but rather included in the outer nuclear layer since it is…

Underwater imagery often exhibits distorted coloration as a result of light-water interactions, which complicates the study of benthic environments in marine biology and geography. In this research, we propose an algorithm to restore the…

Parallel hole collimators which are currently routinely used in SPECT imaging were designed a few decades ago, when filtered backprojection (FBP) was used for tomographic reconstruction. Statistical reconstruction methods with precise…

Dispersion is a common phenomenon in optics due to the frequency dependence of the refractive index in polychromatic light. This issue, if left untreated in optical coherence tomography (OCT) imaging, leads to signal broadening of the…

Our interest has been to study the effect that scattered radiation has on contrast, signal-to-noise ratio and thickness reconstruction in digital mammographies. Using the GEANT code we have performed Monte-Carlo simulations of 25 kVp Mo/Mo…

This dissertation relates to the transition of the state of the art of swept source optical coherence tomography (SS-OCT) systems to a new realm in which the image acquisition speed is improved by an order of magnitude. With the aid of a…

All optical detectors to date annihilate photons upon detection, thus excluding repeated measurements. Here, we demonstrate a robust photon detection scheme which does not rely on absorption. Instead, an incoming photon is reflected off an…

Cone-beam computed tomography (CBCT) typically requires hundreds of X-ray projections, which raises concerns about radiation exposure. While sparse-view reconstruction reduces the exposure by using fewer projections, it struggles to achieve…

For optical coherence tomography angiography (OCTA) images, a limited scanning rate leads to a trade-off between field-of-view (FOV) and imaging resolution. Although larger FOV images may reveal more parafoveal vascular lesions, their…

Prediction of image memorability has attracted interest in various fields. Consequently, the prediction accuracy of convolutional neural network (CNN) models has been approaching the empirical upper bound estimated based on human…

Objective: Positron Emission Tomography (PET) has been a commonly used imaging modality in broad clinical applications. One of the most important tradeoffs in PET imaging is between image quality and radiation dose: high image quality comes…

Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images…

Diabetic retinopathy (DR) is a leading cause of vision loss, requiring early and accurate assessment to prevent irreversible damage. Spectral Domain Optical Coherence Tomography (SD-OCT) enables high-resolution retinal imaging, but…

We demonstrate that a method using the derivative of the selective reflection signal from a nanocell is a convenient and robust tool for atomic laser spectroscopy, achieving a nearly Doppler-free spectral resolution. The recorded linewidth…