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Instance segmentation in electron microscopy (EM) volumes is tough due to complex shapes and sparse annotations. Self-supervised learning helps but still struggles with intricate visual patterns in EM. To address this, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Yinda Chen , Wei Huang , Xiaoyu Liu , Shiyu Deng , Qi Chen , Zhiwei Xiong

Despite the astonishing performance of deep-learning based approaches for visual tasks such as semantic segmentation, they are known to produce miscalibrated predictions, which could be harmful for critical decision-making processes.…

Image and Video Processing · Electrical Eng. & Systems 2021-05-25 Agostina J. Larrazabal , César Martínez , Jose Dolz , Enzo Ferrante

Existing vision tokenization isolates the optimization of vision tokenizers from downstream training, implicitly assuming the visual tokens can generalize well across various tasks, e.g., image generation and visual question answering. The…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Wenxuan Wang , Fan Zhang , Yufeng Cui , Haiwen Diao , Zhuoyan Luo , Huchuan Lu , Jing Liu , Xinlong Wang

The current neuron reconstruction pipeline for electron microscopy (EM) data usually includes automatic image segmentation followed by extensive human expert proofreading. In this work, we aim to reduce human workload by predicting…

Computer Vision and Pattern Recognition · Computer Science 2024-01-09 Qihua Chen , Xuejin Chen , Chenxuan Wang , Yixiong Liu , Zhiwei Xiong , Feng Wu

The prospect of neural reconstruction from Electron Microscopy (EM) images has been elucidated by the automatic segmentation algorithms. Although segmentation algorithms eliminate the necessity of tracing the neurons by hand, significant…

Computer Vision and Pattern Recognition · Computer Science 2015-09-29 Toufiq Parag

Recent success in natural language processing has motivated growing interest in large-scale foundation models for neuroimaging data. Such models often require discretization of continuous neural time series data, a process referred to as…

Machine Learning · Computer Science 2026-02-19 SungJun Cho , Chetan Gohil , Rukuang Huang , Oiwi Parker Jones , Mark W. Woolrich

The performance of existing supervised neuron segmentation methods is highly dependent on the number of accurate annotations, especially when applied to large scale electron microscopy (EM) data. By extracting semantic information from…

Computer Vision and Pattern Recognition · Computer Science 2023-10-09 Yinda Chen , Wei Huang , Shenglong Zhou , Qi Chen , Zhiwei Xiong

Identifying complex neural circuitry from electron microscopic (EM) images may help unlock the mysteries of the brain. However, identifying this circuitry requires time-consuming, manual tracing (proofreading) due to the size and intricacy…

Quantitative Methods · Quantitative Biology 2014-09-04 Stephen M. Plaza

Electron microscopy (EM) imaging offers unparalleled resolution for analyzing neural tissues, crucial for uncovering the intricacies of synaptic connections and neural processes fundamental to understanding behavioral mechanisms. Recently,…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Ruohua Shi , Qiufan Pang , Lei Ma , Lingyu Duan , Tiejun Huang , Tingting Jiang

Semi-supervised semantic segmentation has witnessed remarkable advancements in recent years. However, existing algorithms are based on convolutional neural networks and directly applying them to Vision Transformers poses certain limitations…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Dengke Zhang , Quan Tang , Fagui Liu , Haiqing Mei , C. L. Philip Chen

Automated analysis of electron microscopy datasets poses multiple challenges, such as limitation in the size of the training dataset, variation in data distribution induced by variation in sample quality and experiment conditions, etc. It…

Materials Science · Physics 2022-09-07 Arun Baskaran , Yulin Lin , Jianguo Wen , Maria K. Y. Chan

In the field of connectomics, neuroscientists seek to identify cortical connectivity comprehensively. Neuronal boundary detection from the Electron Microscopy (EM) images is often done to assist the automatic reconstruction of neuronal…

Computer Vision and Pattern Recognition · Computer Science 2017-08-01 Wei Shen , Bin Wang , Yuan Jiang , Yan Wang , Alan Yuille

Medical image segmentation is essential for clinical diagnosis and treatment planning. Although transformer-based methods have achieved remarkable results, their high computational cost hinders clinical deployment. To address this issue, we…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Yaxuan Jiao , Qing Xu , Yuxiang Luo , Xiangjian He , Zhen Chen , Wenting Duan

Conventional Vision-Language Models(VLMs) typically utilize a fixed number of vision tokens, regardless of task complexity. This one-size-fits-all strategy introduces notable inefficiencies: using excessive tokens leads to unnecessary…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Junshan Hu , Jialiang Mao , Zhikang Liu , Zhongpu Xia , Peng Jia , Xianpeng Lang

Unified models aim to support both understanding and generation by encoding images into discrete tokens and processing them alongside text within a single autoregressive framework. This unified design offers architectural simplicity and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Ziyao Wang , Chen Chen , Jingtao Li , Weiming Zhuang , Jiabo Huang , Ang Li , Lingjuan Lyu

Neuron segmentation is the cornerstone of reconstructing comprehensive neuronal connectomes, which is essential for deciphering the functional organization of the brain. The irregular morphology and densely intertwined structures of neurons…

Computer Vision and Pattern Recognition · Computer Science 2026-01-23 Liuyun Jiang , Yizhuo Lu , Yanchao Zhang , Jiazheng Liu , Hua Han

Automated sample preparation and electron microscopy enables acquisition of very large image data sets. These technical advances are of special importance to the field of neuroanatomy, as 3D reconstructions of neuronal processes at the nm…

Efforts to automate the reconstruction of neural circuits from 3D electron microscopic (EM) brain images are critical for the field of connectomics. An important computation for reconstruction is the detection of neuronal boundaries. Images…

Computer Vision and Pattern Recognition · Computer Science 2015-08-21 Kisuk Lee , Aleksandar Zlateski , Ashwin Vishwanathan , H. Sebastian Seung

Accurate segmentation of neural structures in Electron Microscopy (EM) images is paramount for neuroscience. However, this task is challenged by intricate morphologies, low signal-to-noise ratios, and scarce annotations, limiting the…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Zhenghua Li , Hang Chen , Zihao Sun , Kai Li , Xiaolin Hu

Visual tokenization remains a core challenge in unifying visual understanding and generation within the autoregressive paradigm. Existing methods typically employ tokenizers in discrete latent spaces to align with the tokens from large…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Ziyuan Huang , DanDan Zheng , Cheng Zou , Rui Liu , Xiaolong Wang , Kaixiang Ji , Weilong Chai , Jianxin Sun , Libin Wang , Yongjie Lv , Taozhi Huang , Jiajia Liu , Qingpei Guo , Ming Yang , Jingdong Chen , Jun Zhou
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