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Modeling the evolution of high-dimensional systems from limited snapshot observations at irregular time points poses a significant challenge in quantitative biology and related fields. Traditional approaches often rely on dimensionality…

Machine Learning · Computer Science 2025-08-07 Justin Lee , Behnaz Moradijamei , Heman Shakeri

Deep generative models have recently been applied to physical systems governed by partial differential equations (PDEs), offering scalable simulation and uncertainty-aware inference. However, enforcing physical constraints, such as…

Machine Learning · Computer Science 2025-11-27 Utkarsh Utkarsh , Pengfei Cai , Alan Edelman , Rafael Gomez-Bombarelli , Christopher Vincent Rackauckas

Generating high-quality time-series data is challenging because real-world signals often exhibit multimodal patterns and multiscale dynamics, including oscillations and high-frequency variations. Flow Matching (FM) offers an efficient…

Machine Learning · Computer Science 2026-05-29 Junru Zhang , Lang Feng , Jinbo Wang , Xu Guo , Yucheng Wang , Han Yu , Min Wu , Yabo Dong , Duanqing Xu

Numerous biological and physical processes can be modeled as systems of interacting entities evolving continuously over time, e.g. the dynamics of communicating cells or physical particles. Learning the dynamics of such systems is essential…

Generative models have achieved remarkable progress with the emergence of flow matching (FM). It has demonstrated strong generative capabilities and attracted significant attention as a simulation-free flow-based framework capable of…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Huynh Trinh Ngoc , Hoang Anh Nguyen Kim , Toan Nguyen Hai , Long Tran Quoc

The ability of Flow Matching (FM) to model complex conditional distributions has established it as the state-of-the-art for prediction tasks (e.g., robotics, weather forecasting). However, deployment in safety-critical settings is hindered…

Machine Learning · Computer Science 2026-02-16 Constantinos Tsakonas , Serena Ivaldi , Jean-Baptiste Mouret

This paper proposes a novel method, Explicit Flow Matching (ExFM), for training and analyzing flow-based generative models. ExFM leverages a theoretically grounded loss function, ExFM loss (a tractable form of Flow Matching (FM) loss), to…

Machine Learning · Computer Science 2024-07-03 Gleb Ryzhakov , Svetlana Pavlova , Egor Sevriugov , Ivan Oseledets

Flow Matching has limited ability in achieving one-step generation due to its reliance on learned curved trajectories. Previous studies have attempted to address this limitation by either modifying the coupling distribution to prevent…

Machine Learning · Computer Science 2025-11-25 Chenrui Ma , Xi Xiao , Tianyang Wang , Xiao Wang , Yanning Shen

Generative models based on dynamical equations such as flows and diffusions offer exceptional sample quality, but require computationally expensive numerical integration during inference. The advent of consistency models has enabled…

Machine Learning · Computer Science 2025-06-04 Nicholas M. Boffi , Michael S. Albergo , Eric Vanden-Eijnden

Geometric data and purpose-built generative models on them have become ubiquitous in high-impact deep learning application domains, ranging from protein backbone generation and computational chemistry to geospatial data. Current geometric…

Machine Learning · Computer Science 2026-02-10 Oscar Davis , Michael S. Albergo , Nicholas M. Boffi , Michael M. Bronstein , Avishek Joey Bose

Generative models have emerged as a powerful paradigm for solving physics systems and modeling complex spatiotemporal dynamics. However, achieving high physical accuracy without incurring high computational cost remains a fundamental…

Machine Learning · Computer Science 2026-05-27 Jiahe Huang , Sihan Xu , Sharvaree Vadgama , Rose Yu

Flow matching models have shown great potential in image generation tasks among probabilistic generative models. However, most flow matching models in the literature do not explicitly utilize the underlying clustering structure in the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Anirban Samaddar , Yixuan Sun , Viktor Nilsson , Sandeep Madireddy

Conditioning diffusion and flow models have proven effective for super-resolving small-scale details in natural images.However, in physical sciences such as weather, super-resolving small-scale details poses significant challenges due to:…

Computer Vision and Pattern Recognition · Computer Science 2024-10-29 Stathi Fotiadis , Noah Brenowitz , Tomas Geffner , Yair Cohen , Michael Pritchard , Arash Vahdat , Morteza Mardani

The flow matching has rapidly become a dominant paradigm in classical generative modeling, offering an efficient way to interpolate between two complex distributions. We extend this idea to the quantum realm and introduce the Quantum Flow…

Quantum Physics · Physics 2026-02-03 Zidong Cui , Pan Zhang , Ying Tang

Diffusion and flow models have become the dominant paradigm for generative modeling on Riemannian manifolds, with successful applications in protein backbone generation and DNA sequence design. However, these methods require tens to…

Machine Learning · Computer Science 2026-05-04 Dongyeop Woo , Marta Skreta , Seonghyun Park , Kirill Neklyudov , Sungsoo Ahn

Graph generation is a fundamental task with wide applications in modeling complex systems. Although existing methods align the spectrum or degree profile of the target graph, they often ignore the geometry induced by eigenvectors and the…

Machine Learning · Computer Science 2025-10-06 Xikun Huang , Tianyu Ruan , Chihao Zhang , Shihua Zhang

High-dimensional count data arise in applications such as single-cell RNA sequencing and neural spike trains, where mapping between distributions across successive batches or time points form critical components of data analysis. The recent…

Machine Learning · Statistics 2026-05-11 Ganchao Wei , John Pearson

Flow matching has recently emerged as a promising alternative to diffusion-based generative models, offering faster sampling and simpler training by learning continuous flows governed by ordinary differential equations. Despite growing…

Machine Learning · Computer Science 2025-12-02 Mudit Gaur , Prashant Trivedi , Shuchin Aeron , Amrit Singh Bedi , George K. Atia , Vaneet Aggarwal

Generative models for sequential data often struggle with sparsely sampled and high-dimensional trajectories, typically reducing the learning of dynamics to pairwise transitions. We propose Interpolative Multi-Marginal Flow Matching…

Flow Matching (FM) (also referred to as stochastic interpolants or rectified flows) stands out as a class of generative models that aims to bridge in finite time the target distribution $\nu^\star$ with an auxiliary distribution $\mu$,…

Machine Learning · Statistics 2024-09-16 Marta Gentiloni Silveri , Giovanni Conforti , Alain Durmus