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Molecular structure generation is a fundamental problem that involves determining the 3D positions of molecules' constituents. It has crucial biological applications, such as molecular docking, protein folding, and molecular design. Recent…

Machine Learning · Computer Science 2025-08-27 Wenyin Zhou , Christopher Iliffe Sprague , Vsevolod Viliuga , Matteo Tadiello , Arne Elofsson , Hossein Azizpour

Metal-organic frameworks (MOFs) are a class of crystalline materials with promising applications in many areas such as carbon capture and drug delivery. In this work, we introduce MOFFlow, the first deep generative model tailored for MOF…

Biomolecules · Quantitative Biology 2025-03-20 Nayoung Kim , Seongsu Kim , Minsu Kim , Jinkyoo Park , Sungsoo Ahn

Sampling from unnormalized densities is analogous to the generative modeling problem, but the target distribution is defined by a known energy function instead of data samples. Because evaluating the energy function is often costly, a…

Machine Learning · Computer Science 2026-05-06 Aaron Havens , Brian Karrer , Neta Shaul

Flow matching has shown state-of-the-art performance in various generative tasks, ranging from image generation to decision-making, where generation under energy guidance (abbreviated as guidance in the following) is pivotal. However, the…

Machine Learning · Computer Science 2025-05-27 Ruiqi Feng , Chenglei Yu , Wenhao Deng , Peiyan Hu , Tailin Wu

Human trajectory forecasting is important for intelligent multimedia systems operating in visually complex environments, such as autonomous driving and crowd surveillance. Although Conditional Flow Matching (CFM) has shown strong ability in…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Xuepeng Jing , Wenhuan Lu , Hao Meng , Zhizhi Yu , Jianguo Wei

High-dimensional count data arise in applications such as single-cell RNA sequencing and neural spike trains, where mapping between distributions across successive batches or time points form critical components of data analysis. The recent…

Machine Learning · Statistics 2026-05-11 Ganchao Wei , John Pearson

Flow matching (FM) is a general framework for defining probability paths via Ordinary Differential Equations (ODEs) to transform between noise and data samples. Recent approaches attempt to straighten these flow trajectories to generate…

Computer Vision and Pattern Recognition · Computer Science 2024-07-03 Ling Yang , Zixiang Zhang , Zhilong Zhang , Xingchao Liu , Minkai Xu , Wentao Zhang , Chenlin Meng , Stefano Ermon , Bin Cui

The generation of accurate 3D molecular conformations is a pivotal challenge in computational chemistry and drug discovery. Recently, diffusion and flow matching models have achieved remarkable success. However, there is a critical…

Machine Learning · Computer Science 2026-05-26 Yunqing Liu , Yi Zhou , Wenqi Fan

Flow Matching (FM) constructs linear conditional probability paths, but the learned marginal velocity field inevitably exhibits strong curvature due to trajectory superposition. This curvature severely inflates numerical truncation errors,…

Machine Learning · Computer Science 2026-04-07 Tauhid Khan

Flow Matching (FM) is a recent framework for generative modeling that has achieved state-of-the-art performance across various domains, including image, video, audio, speech, and biological structures. This guide offers a comprehensive and…

Open-set supervised anomaly detection (OSAD) aims to identify unseen anomalies using limited anomalous supervision. However, existing prototype-based methods typically model normal data via a unimodal Gaussian prior, failing to capture…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Fuyun Wang , Yuanzhi Wang , Xu Guo , Sujia Huang , Tong Zhang , Dan Wang , Hui Yan , Xin Liu , Zhen Cui

Inverse design aims to find design parameters $x$ achieving target performance $y^*$. Generative approaches learn bidirectional mappings between designs and labels, enabling diverse solution sampling. However, standard conditional flow…

Machine Learning · Computer Science 2026-03-18 Miguel de Campos , Werner Krebs , Hanno Gottschalk

State-of-the-art scene flow algorithms pursue the conflicting targets of accuracy, run time, and robustness. With the successful concept of pixel-wise matching and sparse-to-dense interpolation, we push the limits of scene flow estimation.…

Computer Vision and Pattern Recognition · Computer Science 2019-10-30 René Schuster , Oliver Wasenmüller , Christian Unger , Georg Kuschk , Didier Stricker

Modeling continuous-time dynamics from sparse and irregularly-sampled time series remains a fundamental challenge. Neural controlled differential equations provide a principled framework for such tasks, yet their performance is highly…

Machine Learning · Computer Science 2026-04-03 YongKyung Oh , Dong-Young Lim , Sungil Kim

Existing rectified flow models are based on linear trajectories between data and noise distributions. This linearity enforces zero curvature, which can inadvertently force the image generation process through low-probability regions of the…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Yan Luo , Drake Du , Hao Huang , Yi Fang , Mengyu Wang

High-fidelity Monte Carlo simulations and complex inverse problems, such as mapping smeared experimental observations to ground-truth states, are computationally intensive yet essential for robust data analysis. Conditional Flow Matching…

Machine Learning · Computer Science 2026-04-03 Zeyu Xia , Tyler Kim , Trevor Reed , Judy Fox , Geoffrey Fox , Adam Szczepaniak

Diffusion models have revolutionized generative tasks through high-fidelity outputs, yet flow matching (FM) offers faster inference and empirical performance gains. However, current foundation FM models are computationally prohibitive for…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Johannes Schusterbauer , Ming Gui , Frank Fundel , Björn Ommer

Understanding and predicting object motion from egocentric video is fundamental to embodied perception and interaction. However, generating physically consistent 6DoF trajectories remains challenging due to occlusions, fast motion, and the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Abhishek Saroha , Huajian Zeng , Xingxing Zuo , Daniel Cremers , Xi Wang

Flow matching (FM) has shown promising results in data-driven planning. However, it inherently lacks formal guarantees for ensuring state and action constraints, whose satisfaction is a fundamental and crucial requirement for the safety and…

Machine Learning · Computer Science 2025-12-02 Tzu-Yuan Huang , Armin Lederer , Dai-Jie Wu , Xiaobing Dai , Sihua Zhang , Stefan Sosnowski , Shao-Hua Sun , Sandra Hirche

Energy based models (EBMs) are appealing for their generality and simplicity in data likelihood modeling, but have conventionally been difficult to train due to the unstable and time-consuming implicit MCMC sampling during contrastive…

Machine Learning · Computer Science 2024-07-23 Junn Yong Loo , Michelle Adeline , Arghya Pal , Vishnu Monn Baskaran , Chee-Ming Ting , Raphael C. -W. Phan