Related papers: Single Input Multi Output Model of Molecular Commu…
Recent molecular communication (MC) research has integrated more detailed computational models to capture the dynamics of practical biophysical systems. This research focuses on developing realistic models for MC transceivers inspired by…
Realistic models of the components and processes are required for molecular communication (MC) systems. In this paper, a spheroidal receiver structure is proposed for MC that is inspired by the 3D cell cultures known as spheroids being…
Spherical multi-layered structures are prevalent in numerous biological systems and engineered applications, including tumor spheroids, layered tissues, and multi-shell nanoparticles for targeted drug delivery. Despite their widespread…
Multicellular tumor spheroids are an important {\it in vitro} model of the pre-vascular phase of solid tumors, for sizes well below the diagnostic limit: therefore a biophysical model of spheroids has the ability to shed light on the…
A three-dimensional cell culture called a spheroid serves as a foundational entity in a wide variety of modern tissue engineering applications, including 3D-bioprinting and preclinical drug testing. Lack of oxygen within tissue spheroids…
The multicellular organization of diverse systems, such as embryos, intestines and tumours, relies on the coordinated migration of cells in 3D curved environments. In these settings, cells establish supracellular patterns of motion,…
We describe a viscocapillary instability that can perturb the spherical symmetry of cellular aggregates in culture, also called multicellular spheroids. In the condition where the cells constituting the spheroid get their necessary…
In a diffusion-based molecular communication system, molecules are employed to convey information. When propagation and reception processes are considered in a framework of first passage processes, we need to focus on absorbing receivers.…
Cell spheroids are a widely used model to investigate cell-cell and cell-matrix interactions in a 3D microenvironment in vitro. Most research on cell spheroids has been focused on their response to various stimuli under static conditions.…
Molecular communication is an emerging paradigm for systems that rely on the release of molecules as information carriers. Communication via molecular diffusion is a popular strategy that is ubiquitous in nature and very fast over distances…
The internal and external mechanical environment plays an important role in tumorogenesis. As a proxy of an avascular early state tumor, we use multicellular spheroids, a composite material made of cells, extracellular matrix and permeating…
Molecular communications is a promising framework for the design of controlled-release drug delivery systems. In this framework, drug carriers are modeled as transmitters, the diseased cells as absorbing receivers, and the channel between…
Various biological cells secrete diffusing chemical compounds into their environment for communication purposes. Secretion usually takes place over the cell membrane in a spatially heterogeneous manner. Mathematical models of these…
Cell spheroids are in vitro multicellular model systems that mimic the crowded micro-environment of biological tissues. Their mechanical characterization can provide valuable insights in how single-cell mechanics and cell-cell interactions…
Molecular communication is not only able to mimic biological and chemical communication mechanisms, but also provides a theoretical framework for viral infection processes. In this tutorial, aerosol and droplet transmission is modeled as a…
We extend the continuum theory of active nematic fluids to study cell flows and tissue dynamics inside multicellular spheroids, spherical, self-assembled aggregates of cells that are widely used as model systems to study tumour dynamics.…
One of the hallmarks of pre-migratory tumors is the progressive loss of compact morphology. To investigate how tumors may intrinsically regulate their shape during growth, we employ a three-dimensional (3D) vertex model of multicellular…
In Molecular Communications via Diffusion (MCvD), messenger molecules are emitted by a transmitter and propagate randomly through the fluidic environment. In biological systems, the environment can be considered a bounded space, surrounded…
Molecular communications is a promising framework for the design of controlled-release drug delivery systems. Under this framework, drug carriers, diseased cells, and the channel are modeled as transmitters, absorbing receivers, and…
Molecular communication between biological entities is a new paradigm in communications. Recently, we studied molecular communication between two nodes formed from synthetic bacteria. Due to high randomness in behavior of bacteria, we used…