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Tumor invasion, the process by which tumor cells break away from their primary tumor and gain access to vascular systems, is an important step in cancer metastasis. Most current 3D tumor invasion assays consisted of single tumor cells…

Cell Behavior · Quantitative Biology 2020-02-11 Yu Ling Huang , Carina Shiau , Cindy Wu , Jeffrey E. Segall , Mingming Wu

We propose a discrete in continuous mathematical model describing the in vitro growth process of biophsy-derived mammalian cardiac progenitor cells growing as clusters in the form of spheres (Cardiospheres). The approach is hybrid: discrete…

In this paper we present a mathematical study of particle diffusion inside and outside a spherical biological cell that has been exposed on one side to a propagating planar diffusive front. The media inside and outside the spherical cell…

Biological Physics · Physics 2024-06-11 Sandeep Santhosh Kumar , Stanley J. Miklavcic

The diffusion of colloids inside an active system-e.g. within a living cell or the dynamics of active particles itself (e.g. self-propelled particles) can be modeled through overdamped Langevin equation which contains an additional noise…

Statistical Mechanics · Physics 2024-12-06 Koushik Goswami , K. L. Sebastian

The dispersal of cells from an initially constrained location is a crucial aspect of many physiological phenomena ranging from morphogenesis to tumour spreading. In such processes, the way cell-cell interactions impact the motion of single…

Reaction-diffusion equations describe various spatially extended processes that unfold as traveling fronts moving at constant velocity. We introduce and solve analytically a model that, besides such fronts, supports solutions advancing as…

Biological Physics · Physics 2026-02-13 Louis Brezin , Kyle J. Shaffer , Kirill S. Korolev

During Saccharomyces cerevisiae closed mitosis, parental identity is sustained by the asymmetric segregation of ageing factors. Such asymmetry has been hypothesized to occur via diffusion barriers, constraining protein lateral exchange in…

Subcellular Processes · Quantitative Biology 2014-07-29 Eder Zavala , Tatiana T. Marquez-Lago

In this paper, we consider a two-hop molecular communication network consisting of one nanotransmitter, one nanoreceiver, and one nanotransceiver acting as a relay. We consider two different schemes for relaying to improve the range of…

Information Theory · Computer Science 2016-11-17 Arman Ahmadzadeh , Adam Noel , Robert Schober

This work presents a novel diffusion based dual-phase molecular communication system where the source leverages multiple cooperating nanomachines to improve the end-to-end reliability of communication. The Neyman-Pearson Likelihood Ratio…

Information Theory · Computer Science 2017-10-17 Neeraj Varshney , Adarsh Patel , Aditya K. Jagannatham

Molecule generation is a very important practical problem, with uses in drug discovery and material design, and AI methods promise to provide useful solutions. However, existing methods for molecule generation focus either on 2D graph…

Machine Learning · Computer Science 2024-02-07 Chenqing Hua , Sitao Luan , Minkai Xu , Rex Ying , Jie Fu , Stefano Ermon , Doina Precup

We consider a sequential cascade of molecular first-reaction events towards a terminal reaction centre in which each reaction step is controlled by diffusive motion of the particles. The model studied here represents a typical reaction…

Biological Physics · Physics 2021-10-13 Denis S. Grebenkov , Ralf Metzler , Gleb Oshanin

In this paper, we perform receiver design for a diffusive molecular communication environment. Our model includes flow in any direction, sources of information molecules in addition to the transmitter, and enzymes in the propagation…

Information Theory · Computer Science 2014-10-17 Adam Noel , Karen C. Cheung , Robert Schober

Biological cells can exchange messages through soluble molecules or membrane-bound receptors. In particular in the latter case, the interaction is usually located in specific regions of the interacting cells and may depend on or induce…

Quantitative Methods · Quantitative Biology 2023-12-12 Thorsten Prüstel , Martin Meier-Schellersheim

This paper presents a Markov-based system model for microfluidic molecular communication (MC) channels. By discretizing the advection-diffusion dynamics, the proposed model establishes a physically consistent state-space formulation. The…

Emerging Technologies · Computer Science 2025-11-11 Ruifeng Zheng , Pengjie Zhou , Pit Hofmann , Fatima Rani , Juan A. Cabrera , Frank H. P. Fitzek

In this paper, we consider the diffusive molecular communication channel between a transmitter nano-machine and a receiver nano-machine in a fluid environment. The information molecules released by the transmitter nano-machine into the…

Emerging Technologies · Computer Science 2016-11-17 Arman Ahmadzadeh , Hamidreza Arjmanidi , Andreas Burkovski , Robert Schober

Predicting and controlling the transport of colloids in porous media is essential for applications ranging from contaminant remediation to drug delivery. In these complex environments, solute gradients are ubiquitous and could drive…

Soft Condensed Matter · Physics 2026-05-27 Aditya R. Pujari , Amir A. Pahlavan

In this work, the spread of a contagious disease on a society where the individuals may take precautions is modeled. The primary assumption is that the infected individuals transmit the infection to the susceptible members of the community…

Physics and Society · Physics 2021-03-16 Semra Gunduc

This paper deals with the derivation of a collective model of cell populations out of an individual-based description of the underlying physical particle system. By looking at the spatial distribution of cells in terms of time-evolving…

Mathematical Physics · Physics 2014-11-12 Annachiara Colombi , Marco Scianna , Andrea Tosin

Epidemic disease spreading is conventionally often modelled and analyzed by means of rate and diffusion equations, following the paradigms of well-controlled chemical reactions and diffusive dynamics in a test tube. Yet, serious worries…

Physics and Society · Physics 2023-01-03 Klaus Kroy

Neurotransmitter receptor molecules, concentrated in postsynaptic domains along with scaffold and a number of other molecules, are key regulators of signal transmission across synapses. Employing experiment and theory, we develop a…

Neurons and Cognition · Quantitative Biology 2015-05-20 Christoph A. Haselwandter , Martino Calamai , Mehran Kardar , Antoine Triller , Rava Azeredo da Silveira
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