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In self-supervised learning (SSL), representations are learned via an auxiliary task without annotated labels. A common task is to classify augmentations or different modalities of the data, which share semantic content (e.g. an object in…

Machine Learning · Computer Science 2024-10-16 Alice Bizeul , Bernhard Schölkopf , Carl Allen

Recent years have witnessed remarkable progress in multimodal learning within computational pathology. Existing models primarily rely on vision and language modalities; however, language alone lacks molecular specificity and offers limited…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Minghao Han , Dingkang Yang , Linhao Qu , Zizhi Chen , Gang Li , Han Wang , Jiacong Wang , Lihua Zhang

Self-supervised learning (SSL) enables learning useful inductive biases through utilizing pretext tasks that require no labels. The unlabeled nature of SSL makes it especially important for whole slide histopathological images (WSIs), where…

Computer Vision and Pattern Recognition · Computer Science 2022-11-15 Wisdom Oluchi Ikezogwo , Mehmet Saygin Seyfioglu , Linda Shapiro

Self-supervised learning (SSL) has emerged as a powerful paradigm for Chest X-ray (CXR) analysis under limited annotations. Yet, existing SSL strategies remain suboptimal for medical imaging. Masked image modeling allocates substantial…

Computer Vision and Pattern Recognition · Computer Science 2026-03-25 Wangyu Feng , Shawn Young , Lijian Xu

Improving the feature representation ability is the foundation of many whole slide pathological image (WSIs) tasks. Recent works have achieved great success in pathological-specific self-supervised learning (SSL). However, most of them only…

Computer Vision and Pattern Recognition · Computer Science 2023-07-21 Zhimiao Yu , Tiancheng Lin , Yi Xu

Universal, transferable whole-slide image (WSI) representations are central to computational pathology. Incorporating multiple markers (e.g., immunohistochemistry, IHC) alongside H&E enriches H&E-based features with diverse, biologically…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Yizhi Zhang , Lei Fan , Zhulin Tao , Donglin Di , Yang Song , Sidong Liu , Cong Cong

Representation learning of pathology whole-slide images (WSIs) has been has primarily relied on weak supervision with Multiple Instance Learning (MIL). However, the slide representations resulting from this approach are highly tailored to…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Andrew H. Song , Richard J. Chen , Tong Ding , Drew F. K. Williamson , Guillaume Jaume , Faisal Mahmood

Recent advances in computational pathology have leveraged vision-language models to learn joint representations of Hematoxylin and Eosin (HE) images with spatial transcriptomic (ST) profiles. However, existing approaches typically align HE…

With the development of digital imaging in medical microscopy, artificial intelligent-based analysis of pathological whole slide images (WSIs) provides a powerful tool for cancer diagnosis. Limited by the expensive cost of pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Jiawen Li , Qiehe Sun , Renao Yan , Yizhi Wang , Yuqiu Fu , Yani Wei , Tian Guan , Huijuan Shi , Yonghonghe He , Anjia Han

Self-supervised learning (SSL) has recently achieved tremendous empirical advancements in learning image representation. However, our understanding of the principle behind learning such a representation is still limited. This work shows…

Computer Vision and Pattern Recognition · Computer Science 2023-06-14 Yubei Chen , Adrien Bardes , Zengyi Li , Yann LeCun

With the progress of sensor technology in wearables, the collection and analysis of PPG signals are gaining more interest. Using Machine Learning, the cardiac rhythm corresponding to PPG signals can be used to predict different tasks such…

Signal Processing · Electrical Eng. & Systems 2022-12-20 Ramin Ghorbani , Marcel J. T. Reinders , David M. J. Tax

In recent years, a standard computational pathology workflow has emerged where whole slide images are cropped into tiles, these tiles are processed using a foundation model, and task-specific models are built using the resulting…

Computer Vision and Pattern Recognition · Computer Science 2026-02-26 Eric Zimmermann , Julian Viret , Michal Zelechowski , James Brian Hall , Neil Tenenholtz , Adam Casson , George Shaikovski , Eugene Vorontsov , Siqi Liu , Kristen A Severson

Early cancer detection is crucial for prognosis, but many cancer types lack large labelled datasets required for developing deep learning models. This paper investigates self-supervised learning (SSL) as an alternative to the standard…

Image and Video Processing · Electrical Eng. & Systems 2024-11-27 Hamish Haggerty , Rohitash Chandra

The development of computational pathology lies in the consensus that pathological characteristics of tumors are significant guidance for cancer diagnostics. Most existing research focuses on the inner-contextual information within each WSI…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Jun Shi , Tong Shu , Zhiguo Jiang , Wei Wang , Haibo Wu , Yushan Zheng

While Large Language Models (LLMs) are emerging as a promising direction in computational pathology, the substantial computational cost of giga-pixel Whole Slide Images (WSIs) necessitates the use of Multi-Instance Learning (MIL) to enable…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Zhenfeng Zhuang , Fangyu Zhou , Liansheng Wang

Deep learning technologies have already demonstrated a high potential to build diagnosis support systems from medical imaging data, such as Chest X-Ray images. However, the shortage of labeled data in the medical field represents one key…

Image and Video Processing · Electrical Eng. & Systems 2023-01-26 Iván de Andrés Tamé , Kirill Sirotkin , Pablo Carballeira , Marcos Escudero-Viñolo

Computed tomography (CT) samples with pathological annotations are difficult to obtain. As a result, the computer-aided diagnosis (CAD) algorithms are trained on small datasets (e.g., LIDC-IDRI with 1,018 samples), limiting their accuracies…

Computer Vision and Pattern Recognition · Computer Science 2022-08-24 Penghua Zhai , Enwei Zhu , Baolian Qi , Xin Wei , Jinpeng Li

Semi-supervised learning (SSL) uses unlabeled data during training to learn better models. Previous studies on SSL for medical image segmentation focused mostly on improving model generalization to unseen data. In some applications,…

Current 3D semi-supervised segmentation methods face significant challenges such as limited consideration of contextual information and the inability to generate reliable pseudo-labels for effective unsupervised data use. To address these…

Computer Vision and Pattern Recognition · Computer Science 2023-11-22 Sanaz Karimijafarbigloo , Reza Azad , Yury Velichko , Ulas Bagci , Dorit Merhof

The examination of histopathology images is considered to be the gold standard for the diagnosis and stratification of cancer patients. A key challenge in the analysis of such images is their size, which can run into the gigapixels and can…

Image and Video Processing · Electrical Eng. & Systems 2021-09-09 Joseph Boyd , Mykola Liashuha , Eric Deutsch , Nikos Paragios , Stergios Christodoulidis , Maria Vakalopoulou