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Despite the recent broad adoption of Large Language Models (LLMs) across various domains, their potential for enriching information systems in extracting and exploring Linked Data (LD) and Resource Description Framework (RDF) triplestores…

Information Retrieval · Computer Science 2024-09-25 Omar Mussa , Omer Rana , Benoît Goossens , Pablo Orozco-Terwengel , Charith Perera

Ontology matching (OM) plays an essential role in enabling semantic interoperability and integration across heterogeneous knowledge sources, particularly in the biomedical domain which contains numerous complex concepts related to diseases…

Artificial Intelligence · Computer Science 2026-04-03 Yiping Song , Jiaoyan Chen , Renate A. Schmidt

Large Language Models (LLMs) are transforming language sciences. However, their widespread deployment currently suffers from methodological fragmentation and a lack of systematic soundness. This study proposes two comprehensive…

Computation and Language · Computer Science 2025-12-11 Kun Sun , Rong Wang

Multimodal (MM) learning is emerging as a promising paradigm in biomedical artificial intelligence (AI) applications, integrating complementary modality, which highlight different aspects of patient health. The scarcity of large…

Artificial Intelligence · Computer Science 2025-12-01 Niccolo Marini , Zhaohui Liang , Sivaramakrishnan Rajaraman , Zhiyun Xue , Sameer Antani

Large, publicly available clinical datasets have emerged as a novel resource for understanding disease heterogeneity and to explore personalization of therapy. These datasets are derived from data not originally collected for research…

Machine Learning · Computer Science 2025-08-14 Anish Narain , Ritam Majumdar , Nikita Narayanan , Dominic Marshall , Sonali Parbhoo

The advent of Large Language Models (LLMs) has ushered in a new era for design science in Information Systems, demanding a paradigm shift in tailoring LLMs design for business contexts. We propose and test a novel framework to customize…

Computers and Society · Computer Science 2024-05-15 Wen Wang , Zhenyue Zhao , Tianshu Sun

Crucial information about the practice of healthcare is recorded only in free-form text, which creates an enormous opportunity for high-impact NLP. However, annotated healthcare datasets tend to be small and expensive to obtain, which…

Computation and Language · Computer Science 2019-04-09 Yifeng Tao , Bruno Godefroy , Guillaume Genthial , Christopher Potts

This study analyzes the performance of domain-specific Large Language Models (LLMs) for the medical field by integrating Retrieval-Augmented Generation (RAG) systems within a federated learning framework. Leveraging the inherent advantages…

Computation and Language · Computer Science 2025-01-09 Jincheol Jung , Hongju Jeong , Eui-Nam Huh

The high incidence and mortality rates associated with respiratory diseases underscores the importance of early screening. Machine learning models can automate clinical consultations and auscultation, offering vital support in this area.…

Machine Learning · Computer Science 2024-10-10 Yuwei Zhang , Tong Xia , Aaqib Saeed , Cecilia Mascolo

We introduce LLMD, a large language model designed to analyze a patient's medical history based on their medical records. Along with domain knowledge, LLMD is trained on a large corpus of records collected over time and across facilities,…

Background: Many efforts have been put into the use of automated approaches, such as natural language processing (NLP), to mine or extract data from free-text medical records to construct comprehensive patient profiles for delivering better…

Background: Machine learning methods for clinical named entity recognition and entity normalization systems can utilize both labeled corpora and Knowledge Graphs (KGs) for learning. However, infrequently occurring concepts may have few…

Computation and Language · Computer Science 2024-10-11 Kuleen Sasse , Shinjitha Vadlakonda , Richard E. Kennedy , John D. Osborne

Large Language Models (LLMs) demonstrate remarkable versatility in various NLP tasks but encounter distinct challenges in biomedical due to the complexities of language and data scarcity. This paper investigates LLMs application in the…

Computation and Language · Computer Science 2024-07-12 Masoud Monajatipoor , Jiaxin Yang , Joel Stremmel , Melika Emami , Fazlolah Mohaghegh , Mozhdeh Rouhsedaghat , Kai-Wei Chang

Biomedical research requires large, diverse samples to produce unbiased results. Automated methods for matching variables across datasets can accelerate this process. Research in this area has been limited, primarily focusing on lexical…

Computation and Language · Computer Science 2024-11-06 Zexu Li , Suraj P. Prabhu , Zachary T. Popp , Shubhi S. Jain , Vijetha Balakundi , Ting Fang Alvin Ang , Rhoda Au , Jinying Chen

In this work, we present our various contributions to the objective of building a decision support tool for the diagnosis of rare diseases. Our goal is to achieve a state of knowledge where the uncertainty about the patient's disease is…

A key component of deep learning (DL) for natural language processing (NLP) is word embeddings. Word embeddings that effectively capture the meaning and context of the word that they represent can significantly improve the performance of…

A method to identify probable diseases from the unstructured textual input (eg, health forum posts) by incorporating a lexicographic and semantic feature based two-phase text classification module and a symptom-disease correlation-based…

Information Retrieval · Computer Science 2024-09-05 Fahim Faisal , Shafkat Ahmed Bhuiyan , Abu Raihan Mostofa Kamal

Systemic lupus erythematosus (SLE) is a rare autoimmune disorder characterized by an unpredictable course of flares and remission with diverse manifestations. Lupus nephritis, one of the major disease manifestations of SLE for organ damage…

Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

This paper presents a Lisp architecture for a portable NLP system, termed LAPNLP, for processing clinical notes. LAPNLP integrates multiple standard, customized and in-house developed NLP tools. Our system facilitates portability across…

Computation and Language · Computer Science 2018-11-16 Yuan Luo , Peter Szolovits