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The goal of personalized medicine is to discover a treatment regimen that optimizes a patient's clinical outcome based on their personal genetic and environmental factors. However, candidate treatments cannot be arbitrarily administered to…

Machine Learning · Computer Science 2026-02-09 Michael S. Yao , Osbert Bastani , Alma Andersson , Tommaso Biancalani , Aïcha Bentaieb , Claudia Iriondo

Accurate disease prediction is vital for timely intervention, effective treatment, and reducing medical complications. While symbolic AI has been applied in healthcare, its adoption remains limited due to the effort required for…

Artificial Intelligence · Computer Science 2026-01-01 Ioanna Gemou , Evangelos Lamprou

Pre-trained language models (PLMs) have proven to be effective for document re-ranking task. However, they lack the ability to fully interpret the semantics of biomedical and health-care queries and often rely on simplistic patterns for…

Computation and Language · Computer Science 2023-05-09 Deepak Gupta , Dina Demner-Fushman

Recent advancements in Large Multimodal Models (LMMs) have attracted interest in their generalization capability with only a few samples in the prompt. This progress is particularly relevant to the medical domain, where the quality and…

Computation and Language · Computer Science 2024-05-06 Seonhee Cho , Choonghan Kim , Jiho Lee , Chetan Chilkunda , Sujin Choi , Joo Heung Yoon

In rural regions of several developing countries, access to quality healthcare, medical infrastructure, and professional diagnosis is largely unavailable. Many of these regions are gradually gaining access to internet infrastructure,…

Computation and Language · Computer Science 2021-06-03 Vishal Vinod , Susmit Agrawal , Vipul Gaurav , Pallavi R , Savita Choudhary

Extracting structured medical insights from unstructured clinical text using Natural Language Processing (NLP) remains an open challenge in healthcare, particularly in non-English contexts where resources are scarce. This study presents a…

Artificial Intelligence · Computer Science 2025-11-21 Paulina Tworek , Miłosz Bargieł , Yousef Khan , Tomasz Pełech-Pilichowski , Marek Mikołajczyk , Roman Lewandowski , Jose Sousa

Large language models (LLMs) show promise for extracting clinically meaningful information from unstructured health records, yet their translation into real-world settings is constrained by the lack of scalable and trustworthy validation…

Health monitoring systems have revolutionized modern healthcare by enabling the continuous capture of physiological and behavioral data, essential for preventive measures and early health intervention. While integrating this data with Large…

Machine Learning · Computer Science 2024-06-26 Ajan Subramanian , Zhongqi Yang , Iman Azimi , Amir M. Rahmani

Large language models (LLMs) have immense potential to make information more accessible, particularly in medicine, where complex medical jargon can hinder patient comprehension of clinical notes. We developed a patient-facing tool using…

This paper presents a hybrid framework for literature reviews that augments traditional bibliometric methods with large language models (LLMs). By fine-tuning open-source LLMs, our approach enables scalable extraction of qualitative…

Computation and Language · Computer Science 2025-04-21 Stefano M. Iacus , Haodong Qi , Jiyoung Han

The field of healthcare has increasingly turned its focus towards Large Language Models (LLMs) due to their remarkable performance. However, their performance in actual clinical applications has been underexplored. Traditional evaluations…

Medical ontology graphs map external knowledge to medical codes in electronic health records via structured relationships. By leveraging domain-approved connections (e.g., parent-child), predictive models can generate richer medical concept…

Artificial Intelligence · Computer Science 2025-09-01 Mohsen Nayebi Kerdabadi , Arya Hadizadeh Moghaddam , Dongjie Wang , Zijun Yao

Rare diseases, despite their low individual incidence, collectively impact around 300 million people worldwide due to the vast number of diseases. The involvement of multiple organs and systems, and the shortage of specialized doctors with…

Computation and Language · Computer Science 2025-11-11 Xuanzhong Chen , Ye Jin , Xiaohao Mao , Lun Wang , Shuyang Zhang , Ting Chen

While pioneering deep learning methods have made great strides in analyzing electronic health record (EHR) data, they often struggle to fully capture the semantics of diverse medical codes from limited data. The integration of external…

Machine Learning · Computer Science 2024-08-26 Zhihao Yu , Yujie Jin , Yongxin Xu , Xu Chu , Yasha Wang , Junfeng Zhao

Medical consultation dialogues contain critical clinical information, yet their unstructured nature hinders effective utilization in diagnosis and treatment. Traditional methods, relying on rule-based or shallow machine learning techniques,…

Computation and Language · Computer Science 2025-04-24 Shuguang Zhao , Qiangzhong Feng , Zhiyang He , Peipei Sun , Yingying Wang , Xiaodong Tao , Xiaoliang Lu , Mei Cheng , Xinyue Wu , Yanyan Wang , Wei Liang

Radiology report generation represents a significant application within medical AI, and has achieved impressive results. Concurrently, large language models (LLMs) have demonstrated remarkable performance across various domains. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Haifeng Zhao , Yufei Zhang , Leilei Ma , Shuo Xu , Dengdi Sun

Physician burnout in the United States has reached critical levels, driven in part by the administrative burden of Electronic Health Record (EHR) documentation and complex diagnostic codes. To relieve this strain and maintain strict patient…

Information Retrieval · Computer Science 2026-03-25 Peter Hartnett , Chung-Chi Huang , Sarah Hartnett , David Hartnett

Named Entity Recognition (NER) in the rare disease domain poses unique challenges due to limited labeled data, semantic ambiguity between entity types, and long-tail distributions. In this study, we evaluate the capabilities of GPT-4o for…

Computation and Language · Computer Science 2025-12-30 Nan Miles Xi , Yu Deng , Lin Wang

The utilization of Electronic Health Records (EHRs) for clinical risk prediction is on the rise. However, strict privacy regulations limit access to comprehensive health records, making it challenging to apply standard machine learning…

Computation and Language · Computer Science 2023-12-08 Angeela Acharya , Sulabh Shrestha , Anyi Chen , Joseph Conte , Sanja Avramovic , Siddhartha Sikdar , Antonios Anastasopoulos , Sanmay Das

In the field of Natural Language Processing (NLP), Named Entity Recognition (NER) is recognized as a critical technology, employed across a wide array of applications. Traditional methodologies for annotating datasets for NER models are…

Computation and Language · Computer Science 2025-01-03 Yuji Naraki , Ryosuke Yamaki , Yoshikazu Ikeda , Takafumi Horie , Kotaro Yoshida , Ryotaro Shimizu , Hiroki Naganuma