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Single molecule X-ray scattering experiments with free electron lasers have opened a new route to the structure determination of biomolecules. Because typically only very few photons per scattering image are recorded and thus the…

Computational Physics · Physics 2023-04-17 Steffen Schultze , Helmut Grubmüller

Consistently predicting biopolymer structure at atomic resolution from sequence alone remains a difficult problem, even for small sub-segments of large proteins. Such loop prediction challenges, which arise frequently in comparative…

Biomolecules · Quantitative Biology 2014-03-05 Rhiju Das

The projected electrostatic potential of a thick crystal is reconstructed at atomic-resolution from experimental scanning transmission electron microscopy data recorded using a new generation fast- readout electron camera. This practical…

Materials Science · Physics 2019-01-02 Hamish G. Brown , Zhen Chen , Matthew Weyland , Colin Ophus , Jim Ciston , Les J. Allen , Scott D. Findlay

Machine Learning (ML) techniques are revolutionizing the way to perform efficient materials modeling. Nevertheless, not all the ML approaches allow for the understanding of microscopic mechanisms at play in different phenomena. To address…

Materials Science · Physics 2022-06-22 Udaykumar Gajera , Loriano Storchi , Danila Amoroso , Francesco Delodovici , Silvia Picozzi

Atomic norm minimization (ANM) is a key approach for line spectral estimation (LSE). Most related algorithms formulate ANM as a semidefinite programming (SDP), which incurs high computational cost. In this letter, we revisit the ANM problem…

Optimization and Control · Mathematics 2024-11-14 Xiaozhi Liu , Jinjiang Wei , Yong Xia

Crystal structure prediction (CSP) has emerged as one of the most important approaches for discovering new materials. CSP algorithms based on evolutionary algorithms and particle swarm optimization have discovered a great number of new…

Materials Science · Physics 2022-04-06 Wenhui Yang , Edirisuriya M. Dilanga Siriwardane , Jianjun Hu

To obtain an electron-density map from a macromolecular crystal the phase-problem needs to be solved, which often involves the use of heavy-atom derivative crystals and concomitantly the determination of the heavy atom substructure. This is…

Biomolecules · Quantitative Biology 2018-08-20 Bjørn Panyella Pedersen , Pontus Gourdon , Xiangyu Liu , Jesper Lykkegaard Karlsen , Poul Nissen

Nuclear Magnetic Resonance (NMR) spectroscopy is particularly well-suited to determine the structure of molecules and materials in powdered form. Structure determination usually proceeds by finding the best match between experimentally…

In this work we present RESCU, a powerful MATLAB-based Kohn-Sham density functional theory (KS-DFT) solver. We demonstrate that RESCU can compute the electronic structure properties of systems comprising many thousands of atoms using modest…

Materials Science · Physics 2015-12-31 Vincent Michaud-Rioux , Lei Zhang , Hong Guo

We propose a systematic method to construct crystal-based molecular structures often needed as input for computational chemistry studies. These structures include crystal ``slabs" with periodic boundary conditions (PBCs) and non-periodic…

Materials discovery via high-throughput methods relies on the availability of structural prototypes, which are generally decorated with varying combinations of elements to produce potential new materials. To facilitate the automatic…

Sparse coding consists in representing signals as sparse linear combinations of atoms selected from a dictionary. We consider an extension of this framework where the atoms are further assumed to be embedded in a tree. This is achieved…

Machine Learning · Statistics 2011-08-18 Rodolphe Jenatton , Julien Mairal , Guillaume Obozinski , Francis Bach

While electron microscopy offers crucial atomic-resolution insights into structure-property relationships, radiation damage severely limits its use on beam-sensitive materials like proteins and 2D materials. To overcome this challenge, we…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Zifei Wang , Zian Mao , Xiaoya He , Xi Huang , Haoran Zhang , Chun Cheng , Shufen Chu , Tingzheng Hou , Xiaoqin Zeng , Yujun Xie

PCrystalX-Web is a web application developed to be easy and fast to use. The purpose of the software is that researchers from any area are able to use two methods to analyze an X-ray diffraction pattern more straightforwardly. With the full…

Materials Science · Physics 2022-05-02 Pablo L Bernardo

A novel method, termed Reduced Dimensionality Cluster Identification, RDCI, is presented, for the identification and quantitative description of clusters formed by N objects in three dimensional space. The method consists of finding a path,…

Other Condensed Matter · Physics 2013-06-17 Theophanes Raptis , Vasilios Raptis

In this paper, we demonstrate that atom probe tomography (APT) can be applied to small-molecule organic materials. We show that APT can provide an unprecedented combination of mass resolution of $\lt 1~\mathrm{Da}$, spatial resolution of…

We calculate the structure properties of protoneutron star such as equation of state, maximum mass, radius and temperature profile using the lowest order constrained variational method. We show that the mass and radius of protoneutron star…

Astrophysics · Physics 2009-03-14 G. H. Bordbar , S. M. Zebarjad , R. Zahedinia

Detecting structural chromosomal abnormalities is crucial for accurate diagnosis and management of genetic disorders. However, collecting sufficient structural abnormality data is extremely challenging and costly in clinical practice, and…

Computer Vision and Pattern Recognition · Computer Science 2026-04-02 Yilan Zhang , Hanbiao Chen , Changchun Yang , Yuetan Chu , Siyuan Chen , Jing Wu , Jingdong Hu , Na Li , Junkai Su , Yuxuan Chen , Ao Xu , Xin Gao , Aihua Yin

Model identification is a crucial problem in chemical industries. In recent years, there has been increasing interest in learning data-driven models utilizing partial knowledge about the system of interest. Most techniques for model…

Machine Learning · Computer Science 2020-07-09 Deepak Maurya , Sivadurgaprasad Chinta , Abhishek Sivaram , Raghunathan Rengaswamy

The study of combinations of drugs/drug-schedules gained increasing attention in various therapeutic areas recently. In oncology, the aim of phase I combination clinical trial is to find the maximum tolerated combination (MTC). Many…

Methodology · Statistics 2025-05-09 Weishi Chen , Pavel Mozgunov