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Atypical mitotic figures (AMFs) are important histopathological markers yet remain challenging to identify consistently, particularly under domain shift stemming from scanner, stain, and acquisition differences. We present a simple…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Kaustubh Atey , Sameer Anand Jha , Gouranga Bala , Amit Sethi

Current machine learning methods for medical image analysis primarily focus on developing models tailored for their specific tasks, utilizing data within their target domain. These specialized models tend to be data-hungry and often exhibit…

Image and Video Processing · Electrical Eng. & Systems 2024-07-08 Ece Ozkan , Xavier Boix

Federated learning facilitates the collaborative learning of a global model across multiple distributed medical institutions without centralizing data. Nevertheless, the expensive cost of annotation on local clients remains an obstacle to…

Computer Vision and Pattern Recognition · Computer Science 2024-04-23 Jiayi Chen , Benteng Ma , Hengfei Cui , Yong Xia

Medical Image Analysis (MedIA) has become indispensable in modern healthcare, enhancing clinical diagnostics and personalized treatment. Despite the remarkable advancements supported by deep learning (DL) technologies, their practical…

Image and Video Processing · Electrical Eng. & Systems 2026-04-21 Zixian Su , Jingwei Guo , Xi Yang , Qiufeng Wang , Frans Coenen , Amir Hussain , Kaizhu Huang

Artificial intelligence has shown significant promise in chest radiography, where deep learning models can approach radiologist-level diagnostic performance. Progress has been accelerated by large public datasets such as MIMIC-CXR,…

Machine Learning · Computer Science 2026-03-17 Amy Rafferty , Ajitha Rajan

Domain shift, the mismatch between training and testing data characteristics, causes significant degradation in the predictive performance in multi-source imaging scenarios. In medical imaging, the heterogeneity of population, scanners and…

Machine Learning · Computer Science 2021-12-21 Rongguang Wang , Pratik Chaudhari , Christos Davatzikos

Recent deep learning frameworks in histopathology, particularly multiple instance learning (MIL) combined with pathology foundational models (PFMs), have shown strong performance. However, PFMs exhibit limitations on certain cancer or…

Numerous Deep Learning (DL) classification models have been developed for a large spectrum of medical image analysis applications, which promises to reshape various facets of medical practice. Despite early advances in DL model validation…

Image and Video Processing · Electrical Eng. & Systems 2024-10-22 Sarah Matta , Mathieu Lamard , Philippe Zhang , Alexandre Le Guilcher , Laurent Borderie , Béatrice Cochener , Gwenolé Quellec

Multiple instance learning (MIL) has enabled substantial progress in computational histopathology, where a large amount of patches from gigapixel whole slide images are aggregated into slide-level predictions. Heatmaps are widely used to…

Although multiple instance learning (MIL) methods are widely used for automatic tumor detection on whole slide images (WSI), they suffer from the extreme class imbalance within the small tumor WSIs. This occurs when the tumor comprises only…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Ziyu Su , Mostafa Rezapour , Usama Sajjad , Shuo Niu , Metin Nafi Gurcan , Muhammad Khalid Khan Niazi

Deep learning (DL) has been the primary approach used in various computer vision tasks due to its relevant results achieved on many tasks. However, on real-world scenarios with partially or no labeled data, DL methods are also prone to the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-25 Lucas Fernando Alvarenga e Silva , Daniel Carlos Guimarães Pedronette , Fábio Augusto Faria , João Paulo Papa , Jurandy Almeida

Clinical data is often affected by clinically irrelevant factors such as discrepancies between measurement devices or differing processing methods between sites. In the field of machine learning (ML), these factors are known as domains and…

Deep learning models tend to underperform in the presence of domain shifts. Domain transfer has recently emerged as a promising approach wherein images exhibiting a domain shift are transformed into other domains for augmentation or…

Image and Video Processing · Electrical Eng. & Systems 2022-10-27 Weinan Song , Gaurav Fotedar , Nima Tajbakhsh , Ziheng Zhou , Lei He , Xiaowei Ding

Whole slide image (WSI) assessment is a challenging and crucial step in cancer diagnosis and treatment planning. WSIs require high magnifications to facilitate sub-cellular analysis. Precise annotations for patch- or even pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2023-11-20 Simon Holdenried-Krafft , Peter Somers , Ivonne A. Montes-Majarro , Diana Silimon , Cristina Tarín , Falko Fend , Hendrik P. A. Lensch

Domain shift refers to the difference in the data distribution of two datasets, normally between the training set and the test set for machine learning algorithms. Domain shift is a serious problem for generalization of machine learning…

Image and Video Processing · Electrical Eng. & Systems 2021-09-29 Devran Ugurlu , Esther Puyol-Anton , Bram Ruijsink , Alistair Young , Ines Machado , Kerstin Hammernik , Andrew P. King , Julia A. Schnabel

Early diagnosis of lung cancer is a key intervention for the treatment of lung cancer computer aided diagnosis (CAD) can play a crucial role. However, most published CAD methods treat lung cancer diagnosis as a lung nodule classification…

Image and Video Processing · Electrical Eng. & Systems 2022-10-12 Junhua Chen , Haiyan Zeng , Chong Zhang , Zhenwei Shi , Andre Dekker , Leonard Wee , Inigo Bermejo

Multiple instance learning (MIL) has been extensively applied to whole slide histopathology image (WSI) analysis. The existing aggregation strategy in MIL, which primarily relies on the first-order distance (e.g., mean difference) between…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Yihang Chen , Tsai Hor Chan , Guosheng Yin , Yuming Jiang , Lequan Yu

Data sharing in the medical image analysis field has potential yet remains underappreciated. The aim is often to share datasets efficiently with other sites to train models effectively. One possible solution is to avoid transferring the…

Image and Video Processing · Electrical Eng. & Systems 2025-02-25 Muyang Li , Can Cui , Quan Liu , Ruining Deng , Tianyuan Yao , Marilyn Lionts , Yuankai Huo

Few-shot learning has recently attracted wide interest in image classification, but almost all the current public benchmarks are focused on natural images. The few-shot paradigm is highly relevant in medical-imaging applications due to the…

Computer Vision and Pattern Recognition · Computer Science 2022-06-02 Fereshteh Shakeri , Malik Boudiaf , Sina Mohammadi , Ivaxi Sheth , Mohammad Havaei , Ismail Ben Ayed , Samira Ebrahimi Kahou

Despite the recent success of domain generalization in medical image segmentation, voxel-wise annotation for all source domains remains a huge burden. Semi-supervised domain generalization has been proposed very recently to combat this…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Muyang Qiu , Jian Zhang , Lei Qi , Qian Yu , Yinghuan Shi , Yang Gao