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Radiation therapy has remained as one of the main cancer treatment modalities and a highly cost-effective single modality treatment of cancer care. Typical regimens for fractionated external beam radiotherapy comprise a constant dose…

Medical Physics · Physics 2022-04-19 Jose Alvarez , Kathleen M. Storey , Pavitra Kannan , Heyrim Cho

Chronic diseases constitute the principal burden of morbidity, mortality, and healthcare costs worldwide, yet current health systems remain fragmented and predominantly reactive. Patient Medical Digital Twins (PMDTs) offer a paradigm shift:…

Software Engineering · Computer Science 2026-02-13 Micheal P. Papazoglou , Bernd J. Krämer , Mira Raheem , Amal Elgammal

Stereotactic body radiotherapy (SBRT) is characterized by delivering a high amount of dose in a short period of time. In SBRT the dose is delivered using open fields (e.g., beam's-eye-view) known as "apertures". Mathematical methods can be…

Medical Physics · Physics 2015-06-15 Hamed Yarmand , David Craft

Radiotherapy is a primary treatment for cancers with the aim of applying sufficient radiation dose to the planning target volume (PTV) while minimizing dose hazards to the organs at risk (OARs). Convolutional neural networks (CNNs) have…

Image and Video Processing · Electrical Eng. & Systems 2024-02-08 Lu Wen , Qihun Zhang , Zhenghao Feng , Yuanyuan Xu , Xiao Chen , Jiliu Zhou , Yan Wang

Background: Dual-energy imaging on cone-beam CT (CBCT) scanners has great potential in different clinical applications, including image-guided surgery and adaptive proton therapy. However, the clinical practice of dual-energy CBCT (DE-CBCT)…

PET imaging is widely employed for observing biological metabolic activities within the human body. However, numerous benign conditions can cause increased uptake of radiopharmaceuticals, confounding differentiation from malignant tumors.…

Image and Video Processing · Electrical Eng. & Systems 2024-10-31 Ran Hong , Yuxia Huang , Lei Liu , Zhonghui Wu , Bingxuan Li , Xuemei Wang , Qiegen Liu

Adaptive therapy is a dynamic cancer treatment protocol that updates (or "adapts") treatment decisions in anticipation of evolving tumor dynamics. This broad term encompasses many possible dynamic treatment protocols of patient-specific…

Medical image registration and segmentation are two of the most frequent tasks in medical image analysis. As these tasks are complementary and correlated, it would be beneficial to apply them simultaneously in a joint manner. In this paper,…

Image and Video Processing · Electrical Eng. & Systems 2021-05-06 Mohamed S. Elmahdy , Laurens Beljaards , Sahar Yousefi , Hessam Sokooti , Fons Verbeek , U. A. van der Heide , Marius Staring

Surgical phase recognition (SPR) is an integral component of surgical data science, enabling high-level surgical analysis. End-to-end trained neural networks that predict surgical phase directly from videos have shown excellent performance…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Hao Ding , Yuqian Zhang , Wenzheng Cheng , Xinyu Wang , Xu Lian , Chenhao Yu , Hongchao Shu , Ji Woong Kim , Axel Krieger , Mathias Unberath

Quantifying the uncertainty in predictive models is critical for establishing trust and enabling risk-informed decision making for personalized medicine. In contrast to one-size-fits-all approaches that seek to mitigate risk at the…

Computational Engineering, Finance, and Science · Computer Science 2025-05-15 Graham Pash , Umberto Villa , David A. Hormuth , Thomas E. Yankeelov , Karen Willcox

This paper introduces a novel dynamic optimization framework for video streaming that leverages Network Digital Twin (NDT) technology to address the challenges posed by fluctuating wireless network conditions. Traditional adaptive streaming…

Networking and Internet Architecture · Computer Science 2025-08-05 Zurh Farus , Betty Searcy , Tina Nassisid , Kevin Muhammad

Purpose: Radiotherapy commonly relies on CT, but there is growing interest in using hybrid PET/MR. Therefore, dedicated hardware setups have been proposed for PET/MR systems which enable imaging in radiotherapy treatment position. These…

Medical Physics · Physics 2024-11-14 R. M. Winter , O. Engelsen , O. J. Bratting , N. Brekke , J. Sæterstøl , O. Sæther , K. R. Redalen

The emergence of beyond 5G (B5G) and 6G networks underscores the critical role of advanced computer-aided tools, such as network digital twins (DTs), in fostering autonomous networks and ubiquitous intelligence. Existing solutions in the DT…

Networking and Internet Architecture · Computer Science 2024-09-04 Caglar Tunc , Kubra Duran , Buse Bilgin , Gokhan Kalem , Berk Canberk

Stereotactic body radiation therapy (SBRT) for pancreatic cancer requires a skillful approach to deliver ablative doses to the tumor while limiting dose to the highly sensitive duodenum, stomach, and small bowel. Here, we develop…

In this paper, we investigate a novel digital network twin (DNT) assisted deep learning (DL) model training framework. In particular, we consider a physical network where a base station (BS) uses several antennas to serve multiple mobile…

Networking and Internet Architecture · Computer Science 2026-03-11 Hanzhi Yu , Hasan Farooq , Julien Forgeat , Shruti Bothe , Kristijonas Cyras , Md Moin Uddin Chowdhury , Mingzhe Chen

Radiotherapy treatment for prostate cancer relies on computed tomography (CT) and/or magnetic resonance imaging (MRI) for segmentation of target volumes and organs at risk (OARs). Manual segmentation of these volumes is regarded as the gold…

Commonly adopted in the manufacturing and aerospace sectors, digital twin (DT) platforms are increasingly seen as a promising paradigm to control and monitor software-based, "open", communication systems, which play the role of the physical…

Signal Processing · Electrical Eng. & Systems 2023-01-30 Clement Ruah , Osvaldo Simeone , Bashir Al-Hashimi

Cone-beam CT (CBCT) provides on-board volumetric anatomy for image guidance and treatment adaptation in radiotherapy. To compensate for respiration-induced anatomical motion, time-resolved CBCT is highly desired to capture the…

Medical Physics · Physics 2025-11-05 Ruizhi Zuo , Hua-Chieh Shao , You Zhang

Objective: Machine learning (ML) based radiation treatment (RT) planning addresses the iterative and time-consuming nature of conventional inverse planning. Given the rising importance of Magnetic resonance (MR) only treatment planning…

Medical Physics · Physics 2022-06-13 Aly Khalifa , Jeff Winter , Inmaculada Navarro , Chris McIntosh , Thomas G. Purdie

In this paper, we study a digital twin (DT)-empowered integrated sensing, communication, and computation network. Specifically, the users perform radar sensing and computation offloading on the same spectrum, while unmanned aerial vehicles…

Signal Processing · Electrical Eng. & Systems 2023-10-27 Bin Li , Wenshuai Liu , Wancheng Xie , Ning Zhang , Yan Zhang