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A framework for online robust adaptive radiation therapy (ART) is presented. This framework is designed to (i) handle interfractional geometric variations following a probability distribution different from the a priori hypothesis, (ii)…

Medical Physics · Physics 2020-09-09 Michelle Böck

Advanced radiotherapy approaches such as FLASH irradiation and spatially fractionated radiotherapy (SFRT) show potential to improve the therapeutic ratio, yet their biological mechanisms and optimal delivery parameters remain uncertain.…

A central problem in the field of radiation therapy (RT) is how to optimally deliver dose to a patient in a way that fully accounts for anatomical position changes over time. As current RT is a static process, where beam intensities are…

Medical Physics · Physics 2019-09-04 Rodney D. Wiersma , Xinmin Liu

Radiotherapy continues to become more precise and data dense, with current treatment regimens generating high frequency imaging and dosimetry streams ideally suited for AI driven temporal modeling to characterize how normal tissues evolve…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Anvi Sud , Jialu Huang , Gregory R. Hart , Keshav Saxena , John Kim , Lauren Tressel , Jun Deng

A survey was designed to inquire about the practice of proton SBRT treatment for prostate cancer. The survey was distributed to all 30 proton therapy centers in the United States that participate in the National Clinical Trial Network in…

Proton therapy offers superior organ-at-risk sparing but is highly sensitive to anatomical changes, making accurate deformable image registration (DIR) across longitudinal CT scans essential. Conventional DIR methods are often too slow for…

We propose an oAPT workflow that incorporates all these functionalities and validate its clinical implementation feasibility with prostate patients. AI-based auto-segmentation tool AccuContourTM (Manteia, Xiamen, China) was seamlessly…

Digital twin (DT), refers to a promising technique to digitally and accurately represent actual physical entities. One typical advantage of DT is that it can be used to not only virtually replicate a system's detailed operations but also…

Networking and Internet Architecture · Computer Science 2023-09-08 Jiayuan Chen , Changyan Yi , Samuel D. Okegbile , Jun Cai , Xuemin , Shen

This paper investigates the transformative potential of digital twin (DT) technology for non-terrestrial networks (NTNs). NTNs, comprising airborne and space-borne elements, face unique challenges in network control, management, and…

Networking and Internet Architecture · Computer Science 2024-11-20 Hayder Al-Hraishawi , Madyan Alsenwi , Junaid ur Rehman , Eva Lagunas , Symeon Chatzinotas

Digital twins, virtual simulated replicas of physical scenes, are transforming system design across industries. However, their potential in radio frequency (RF) systems has been limited by the non-differentiable nature of conventional RF…

Signal Processing · Electrical Eng. & Systems 2026-03-20 Xingyu Chen , Xinyu Zhang , Kai Zheng , Xinmin Fang , Tzu-Mao Li , Chris Xiaoxuan Lu , Zhengxiong Li

Digital Twin (DT) technologies are transforming manufacturing by enabling real-time prediction, monitoring, and control of complex processes. Yet, applying DT to deformation-based metal forming remains challenging because of the strongly…

Systems and Control · Electrical Eng. & Systems 2025-11-17 Yi-Ping Chen , Derick Suarez , Ying-Kuan Tsai , Vispi Karkaria , Guanzhong Hu , Zihan Chen , Ping Guo , Jian Cao , Wei Chen

Anatomical changes during intensity-modulated proton therapy (IMPT) for head-and-neck cancer (HNC) can shift Bragg peaks, risking tumor underdosing and organ-at-risk overdosing. Treatment replanning is often required to maintain clinically…

Medical Physics · Physics 2025-08-13 Malvern Madondo , Yuan Shao , Yingzi Liu , Jun Zhou , Xiaofeng Yang , Zhen Tian

Digital twin (DT) is one of the most promising enabling technologies for realizing smart grids. Characterized by seamless and active---data-driven, real-time, and closed-loop---integration between digital and physical spaces, a DT is much…

Signal Processing · Electrical Eng. & Systems 2019-09-17 Xing He , Qian Ai , Robert C. Qiu , Dongxia Zhang

Radiation therapy with protons as of today utilizes information from x-ray CT in order to estimate the proton stopping power of the traversed tissue in a patient. The conversion from x-ray attenuation to proton stopping power in tissue…

A human body digital twin (DT) is a virtual representation of an individual's physiological state, created using real-time data from sensors and medical test devices, with the purpose of simulating, predicting, and optimizing health…

Artificial Intelligence · Computer Science 2024-04-24 Chenyu Tang , Wentian Yi , Edoardo Occhipinti , Yanning Dai , Shuo Gao , Luigi G. Occhipinti

Contouring of the target volume and Organs-At-Risk (OARs) is a crucial step in radiotherapy treatment planning. In an adaptive radiotherapy setting, updated contours need to be generated based on daily imaging. In this work, we leverage…

Image and Video Processing · Electrical Eng. & Systems 2020-02-19 Mohamed S. Elmahdy , Tanuj Ahuja , U. A. van der Heide , Marius Staring

With the accelerating availability of multimodal surgical data and real-time computation, Surgical Digital Twins (SDTs) have emerged as virtual counterparts that mirror, predict, and inform decisions across pre-, intra-, and postoperative…

With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…

Medical Physics · Physics 2018-12-03 Dan Nguyen , Troy Long , Xun Jia , Weiguo Lu , Xuejun Gu , Zohaib Iqbal , Steve Jiang

Radiation therapy is an important tool in the treatment of breast cancer and can play a crucial role in improving patient outcomes. For breast cancer, if the technique has been for a long time the use of 3DCRT, clinicians have seen the…

Current neural interfaces such as brain-computer interfaces (BCIs) face several fundamental challenges, including frequent recalibration due to neuroplasticity and session-to-session variability, real-time processing latency, limited…

Human-Computer Interaction · Computer Science 2026-01-06 Mohammad Mahdi Habibi Bina , Sepideh Baghernezhad , Mohammad Reza Daliri , Mohammad Hassan Moradi