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The study of healthy brain development helps to better understand the brain transformation and brain connectivity patterns which happen during childhood to adulthood. This study presents a sparse machine learning solution across whole-brain…

Machine Learning · Computer Science 2019-04-03 Peyman Hosseinzadeh Kassani , Alexej Gossmann , Yu-Ping Wang

We explore the value of weak labels in learning transferable representations for medical images. Compared to hand-labeled datasets, weak or inexact labels can be acquired in large quantities at significantly lower cost and can provide…

Computer Vision and Pattern Recognition · Computer Science 2021-08-05 Boon Peng Yap , Beng Koon Ng

Deep learning models in medical imaging are susceptible to shortcut learning, relying on confounding metadata (e.g., scanner model) that is often encoded in image embeddings. The crucial question is whether the model actively utilizes this…

Computer Vision and Pattern Recognition · Computer Science 2026-02-05 Chun Kit Wong , Paraskevas Pegios , Nina Weng , Emilie Pi Fogtmann Sejer , Martin Grønnebæk Tolsgaard , Anders Nymark Christensen , Aasa Feragen

Predicting stroke risk is a complex challenge that can be enhanced by integrating diverse clinically available data modalities. This study introduces a self-supervised multimodal framework that combines 3D brain imaging, clinical data, and…

Computer Vision and Pattern Recognition · Computer Science 2025-07-09 Camille Delgrange , Olga Demler , Samia Mora , Bjoern Menze , Ezequiel de la Rosa , Neda Davoudi

Computed tomography (CT) samples with pathological annotations are difficult to obtain. As a result, the computer-aided diagnosis (CAD) algorithms are trained on small datasets (e.g., LIDC-IDRI with 1,018 samples), limiting their accuracies…

Computer Vision and Pattern Recognition · Computer Science 2022-08-24 Penghua Zhai , Enwei Zhu , Baolian Qi , Xin Wei , Jinpeng Li

The study of brain morphology changes in normal individuals may capture aspects of functionally-relevant brain aging not fully indicated by gross volumetry. Despite the important role of subcortical brain structures in cognition, the…

Contrastive self-supervised learning based on point-wise comparisons has been widely studied for vision tasks. In the visual cortex of the brain, neuronal responses to distinct stimulus classes are organized into geometric structures known…

Machine Learning · Computer Science 2026-01-06 Guanming Zhang , David J. Heeger , Stefano Martiniani

High-dimensional neuroimaging analyses for clinical diagnosis are often constrained by compromises in spatiotemporal fidelity and by the limited adaptability of large-scale, general-purpose models. To address these challenges, we introduce…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Meihua Zhou , Xinyu Tong , Jiarui Zhao , Min Cheng , Li Yang , Lei Tian , Nan Wan

Deterministic embeddings learned by contrastive learning (CL) methods such as SimCLR and SupCon achieve state-of-the-art performance but lack a principled mechanism for uncertainty quantification. We propose Variational Contrastive Learning…

Machine Learning · Computer Science 2025-10-08 Minoh Jeong , Seonho Kim , Alfred Hero

Biological brains learn continually from a stream of unlabeled data, while integrating specialized information from sparsely labeled examples without compromising their ability to generalize. Meanwhile, machine learning methods are…

Machine Learning · Computer Science 2026-01-27 Viet Anh Khoa Tran , Emre Neftci , Willem A. M. Wybo

Event-based vision sensors provide significant advantages for high-speed perception, including microsecond temporal resolution, high dynamic range, and low power consumption. When combined with Spiking Neural Networks (SNNs), they can be…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Maxime Vaillant , Axel Carlier , Lai Xing Ng , Christophe Hurter , Benoit R. Cottereau

Recent studies have noted an intriguing phenomenon termed Neural Collapse, that is, when the neural networks establish the right correlation between feature spaces and the training targets, their last-layer features, together with the…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Yining Wang , Junjie Sun , Chenyue Wang , Mi Zhang , Min Yang

Supervised classification has a theoretical optimum, Neural Collapse (NC), yet neither of its two dominant paradigms reaches it in practice. Cross entropy (CE) leaves radial degrees of freedom unconstrained and converges to a degenerate…

Machine Learning · Computer Science 2026-05-22 Panagiotis Koromilas , Theodoros Giannakopoulos , Mihalis A. Nicolaou , Yannis Panagakis

Major depressive disorder (MDD) is a common neuropsychiatric condition whose accurate diagnosis from resting-state functional magnetic resonance imaging (rs-fMRI) remains difficult. Dynamic functional connectivity (DFC) captures…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Muhammad Asif Hasan , Yanming Zhu , Xuefei Yin , Alan Wee-Chung Liew

Our brain functions as a complex communication network, and studying it from a network perspective offers valuable insights into its organizational principles and links to cognitive functions and brain disorders. However, most current…

Neurons and Cognition · Quantitative Biology 2026-01-21 Chao Cao , Tong Chen , Nan Zhao , Minheng Chen , Michael Qu , Zeyu Zhang , Xiao Shi , Xiang Li , Tianming Liu , Lu Zhang

Brain age prediction models have succeeded in predicting clinical outcomes in neurodegenerative diseases, but can struggle with tasks involving faster progressing diseases and low quality data. To enhance their performance, we employ a…

Memorization studies of deep neural networks (DNNs) help to understand what patterns and how do DNNs learn, and motivate improvements to DNN training approaches. In this work, we investigate the memorization properties of SimCLR, a widely…

Machine Learning · Computer Science 2021-07-22 Ildus Sadrtdinov , Nadezhda Chirkova , Ekaterina Lobacheva

Contrastive learning -- a modern approach to extract useful representations from unlabeled data by training models to distinguish similar samples from dissimilar ones -- has driven significant progress in foundation models. In this work, we…

Machine Learning · Statistics 2025-10-15 Licong Lin , Song Mei

We propose a novel theoretical framework to understand contrastive self-supervised learning (SSL) methods that employ dual pairs of deep ReLU networks (e.g., SimCLR). First, we prove that in each SGD update of SimCLR with various loss…

Machine Learning · Computer Science 2021-02-16 Yuandong Tian , Lantao Yu , Xinlei Chen , Surya Ganguli

Most deep neural networks (DNNs) based ultrasound (US) medical image analysis models use pretrained backbones (e.g., ImageNet) for better model generalization. However, the domain gap between natural and medical images causes an inevitable…

Computer Vision and Pattern Recognition · Computer Science 2021-09-03 Yixiong Chen , Chunhui Zhang , Li Liu , Cheng Feng , Changfeng Dong , Yongfang Luo , Xiang Wan