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Multi-modal biological, imaging, and neuropsychological markers have demonstrated promising performance for distinguishing Alzheimer's disease (AD) patients from cognitively normal elders. However, it remains difficult to early predict when…

Computer Vision and Pattern Recognition · Computer Science 2019-01-08 Hongming Li , Yong Fan

We describe a new method to automatically discriminate between patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI) and elderly controls, based on multidimensional classification of hippocampal shape features. This…

Brain stroke is a leading cause of mortality and long-term disability worldwide, underscoring the need for precise and rapid prediction techniques. Computed Tomography (CT) scan is considered one of the most effective methods for diagnosing…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Md. Sabbir Hossen , Eshat Ahmed Shuvo , Shibbir Ahmed Arif , Pabon Shaha , Anichur Rahman , Md. Saiduzzaman , Fahmid Al Farid , Hezerul Abdul Karim , Abu Saleh Musa Miah

Alzheimer's disease (AD) is an irreversible devastative neurodegenerative disorder associated with progressive impairment of memory and cognitive functions. Its early diagnosis is crucial for the development of possible future treatment…

Computer Vision and Pattern Recognition · Computer Science 2020-04-07 Ahsan Bin Tufail , Qiu-Na Zhang , Yong-Kui Ma

Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disease which destroys brain cells and causes loss to patient's memory. An early detection can prevent the patient from further damage of the brain cells and hence…

Image and Video Processing · Electrical Eng. & Systems 2021-01-11 Ali Nawaz , Syed Muhammad Anwar , Rehan Liaqat , Javid Iqbal , Ulas Bagci , Muhammad Majid

The aging society urgently requires scalable methods to monitor cognitive decline and identify social and psychological factors indicative of dementia risk in older adults. Our machine learning (ML) models captured facial, acoustic,…

Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients'life. The emerging computer-aided…

Image and Video Processing · Electrical Eng. & Systems 2021-07-29 Fan Zhang , Bo Pan , Pengfei Shao , Peng Liu , Shuwei Shen , Peng Yao , Ronald X. Xu

Due to the rapid innovation of technology and the desire to find and employ biomarkers for neurodegenerative disease, high-dimensional data classification problems are routinely encountered in neuroimaging studies. To avoid over-fitting and…

Machine Learning · Statistics 2018-06-19 Shan Shi , Farouk Nathoo

Alzheimer's disease is a progressive neurodegenerative disorder that gradually deprives the patient of cognitive function and can end in death. With the advancement of technology today, it is possible to detect Alzheimer's disease through…

Image and Video Processing · Electrical Eng. & Systems 2022-07-05 Muhammad Wildan Oktavian , Novanto Yudistira , Achmad Ridok

An interpretable machine learning (ML) framework is introduced to enhance the diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) by ensuring robustness of the ML models' interpretations. The dataset used comprises…

Brain tumors pose a significant global health challenge due to their high prevalence and mortality rates across all age groups. Detecting brain tumors at an early stage is crucial for effective treatment and patient outcomes. This study…

Image and Video Processing · Electrical Eng. & Systems 2023-10-30 Jonayet Miah , Duc M Cao , Md Abu Sayed3 , Md Siam Taluckder , Md Sabbirul Haque , Fuad Mahmud

Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD,…

Quantitative Methods · Quantitative Biology 2025-01-27 Roberto Goya-Maldonado , Tracy Erwin-Grabner , Ling-Li Zeng , Christopher R. K. Ching , Andre Aleman , Alyssa R. Amod , Zeynep Basgoze , Francesco Benedetti , Bianca Besteher , Katharina Brosch , Robin Bülow , Romain Colle , Colm G. Connolly , Emmanuelle Corruble , Baptiste Couvy-Duchesne , Kathryn Cullen , Udo Dannlowski , Christopher G. Davey , Annemiek Dols , Jan Ernsting , Jennifer W. Evans , Lukas Fisch , Paola Fuentes-Claramonte , Ali Saffet Gonul , Ian H. Gotlib , Hans J. Grabe , Nynke A. Groenewold , Dominik Grotegerd , Tim Hahn , J. Paul Hamilton , Laura K. M. Han , Ben J. Harrison , Tiffany C. Ho , Neda Jahanshad , Alec J. Jamieson , Andriana Karuk , Tilo Kircher , Bonnie Klimes-Dougan , Sheri-Michelle Koopowitz , Thomas Lancaster , Ramona Leenings , Meng Li , David E. J. Linden , Frank P. MacMaster , David M. A. Mehler , Susanne Meinert , Elisa Melloni , Bryon A. Mueller , Benson Mwangi , Igor Nenadić , Amar Ojha , Yasumasa Okamoto , Mardien L. Oudega , Brenda W. J. H. Penninx , Sara Poletti , Edith Pomarol-Clotet , Maria J. Portella , Elena Pozzi , Joaquim Radua , Elena Rodríguez-Cano , Matthew D. Sacchet , Raymond Salvador , Anouk Schrantee , Kang Sim , Jair C. Soares , Aleix Solanes , Dan J. Stein , Frederike Stein , Aleks Stolicyn , Sophia I. Thomopoulos , Yara J. Toenders , Aslihan Uyar-Demir , Eduard Vieta , Yolanda Vives-Gilabert , Henry Völzke , Martin Walter , Heather C. Whalley , Sarah Whittle , Nils Winter , Katharina Wittfeld , Margaret J. Wright , Mon-Ju Wu , Tony T. Yang , Carlos Zarate , Dick J. Veltman , Lianne Schmaal , Paul M. Thompson

Recently, machine learning techniques especially predictive modeling and pattern recognition in biomedical sciences from drug delivery system to medical imaging has become one of the important methods which are assisting researchers to have…

Computer Vision and Pattern Recognition · Computer Science 2017-05-23 Saman Sarraf , Ghassem Tofighi

Brain functional connectivity (FC) extracted from resting-state fMRI (RS-fMRI) has become a popular approach for disease diagnosis, where discriminating subjects with mild cognitive impairment (MCI) from normal controls (NC) is still one of…

Computer Vision and Pattern Recognition · Computer Science 2018-08-31 Weizheng Yan , Han Zhang , Jing Sui , Dinggang Shen

A great deal of effort has been devoted to discovering a particular genetic disorder, but its classification across a broad spectrum of disorder classes and types remains elusive. Early diagnosis of genetic disorders enables timely…

Artificial Intelligence · Computer Science 2024-12-04 Abu Bakar Siddik , Faisal R. Badal , Afroza Islam

The increasing global prevalence of mental disorders, such as depression and PTSD, requires objective and scalable diagnostic tools. Traditional clinical assessments often face limitations in accessibility, objectivity, and consistency.…

Audio and Speech Processing · Electrical Eng. & Systems 2025-04-03 Abdelrahaman A. Hassan , Abdelrahman A. Ali , Aya E. Fouda , Radwa J. Hanafy , Mohammed E. Fouda

Early and accurate diagnosis of Alzheimer Disease is critical for effective clinical intervention, particularly in distinguishing it from Mild Cognitive Impairment, a prodromal stage marked by subtle structural changes. In this study, we…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Fahad Mostafa , Kannon Hossain , Hafiz Khan

Alzheimer's Disease destroys brain cells causing people to lose their memory, mental functions and ability to continue daily activities. It is a severe neurological brain disorder which is not curable, but earlier detection of Alzheimer's…

Computer Vision and Pattern Recognition · Computer Science 2017-12-21 Jyoti Islam , Yanqing Zhang

Magnetic resonance imaging (MRI) is a common technique to scan brains for strokes, tumors, and other abnormalities that cause forms of dementia. However, correctly diagnosing forms of dementia from MRIs is difficult, as nearly 1 in 3…

Quantum Physics · Physics 2023-05-16 Ryan Kim

Depression has affected millions of people worldwide and has become one of the most common mental disorders. Early mental disorder detection can reduce costs for public health agencies and prevent other major comorbidities. Additionally,…

Computation and Language · Computer Science 2024-04-09 Giuliano Lorenzoni , Cristina Tavares , Nathalia Nascimento , Paulo Alencar , Donald Cowan